University of Alberta scientists find a new application for an existing drug, with potential to slow progression of the devastating degenerative disease.
A new drug could significantly slow the progression of ALS, also known as Lou Gehrig’s disease, according to new research by University of Alberta biologists. Current treatments slow progression of the degenerative disease by only a few months, and these findings could revolutionize the treatment of patients suffering from ALS, extending and improving quality of life.
The drug, called telbivudine, targets a protein that misfolds and does not function correctly in patients with ALS. “SOD1 is a protein that is known to misfold and misbehave in most cases of patients with ALS,” explained Ted Allison, associate professor in the Department of Biological Sciences and co-author on the study. “We showed that telbivudine can greatly reduce the toxic properties of SOD1, including improving the health of the subject’s motor neurons and improving movement.”
The research team used computer simulations to identify drugs with the potential for targeting the SOD1 protein. From this shortlist, the scientists identified and tested the most likely candidates—including telbivudine—using animal models.
“ALS is not well-understood,” said lead author Michele DuVal, who recently completed the PhD portion of the Faculty of Medicine & Dentistry’sMD/PhD program under the supervision of Allison. “We don’t yet know exactly what goes wrong first in the motor neurons or how the misbehaving SOD1 causes toxicity. Because there is still much to learn about the disease, the ALS research community focuses on both understanding ALS and on developing promising therapies.”
The discovery of telbivudine as a potential treatment is particularly exciting because the drug is already in use for treating patients with hepatitis. “It is already proven safe to use in patients, and it has very good potential for repurposing to use in a new clinical setting against ALS,” said Allison.
The Latest on: Lou Gehrig’s disease
via Google News
The Latest on: Lou Gehrig’s disease
- Lower Merion Police Officer Passes After ALS Fight At 49 on February 19, 2019 at 6:17 am
from complications from Amyotrophic Lateral Sclerosis more commonly known as ALS or Lou Gehrig's Disease He was 49. The beloved son of Armand and Joan Plisinski Temoyan, Gary was born on December ... […]
- Ben-Gurion University Introduces Novel AI Platform for Monitoring and Predicting ALS Progression on February 19, 2019 at 3:00 am
The technology, developed by Prof. Boaz Lerner of the Department of Industrial Engineering and Management at BGU, will initially focus on amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's ... […]
- Dear Dr. Roach: How do diseases get their names? on February 19, 2019 at 2:00 am
Dear Dr. Roach: How does a medical condition get named? Once named, can the name be changed (for example, Lou Gehrig's disease, ALS)? I have a condition called hemiplegic migraines. It is rare and ... […]
- The Alumni Association’s 50th Buckeye Smart Series highlights ALS researchers at Ohio State and the search for the cure on February 18, 2019 at 10:35 pm
The luncheon, hosted by Dr. Stephen Kolb, will highlight the efforts of Ohio State researchers and clinicians who strive to find a cure for amyotrophic lateral sclerosis, also known as ALS or Lou Gehr... […]
- Former Yank Gehrig cap could sell for $200K at auction on February 18, 2019 at 8:03 pm
Gehrig retired in 1939 because amyotrophic lateral sclerosis (ALS), later called Lou Gehrig's disease. He was inducted into the Hall of Fame the same year and died in 1941. Steigler originally inherit... […]
- Lou Gehrig memorabilia up for auction on February 18, 2019 at 12:53 pm
Gehrig retired in 1939 because amyotrophic lateral sclerosis (ALS), later called Lou Gehrig’s disease. He was inducted into the Hall of Fame the same year and died in 1941. Steigler originally inherit... […]
- Lower Merion Police Officer succumbs to ALS. Lou Gehrig’s Disease on February 17, 2019 at 8:00 pm
Ardmore, Lower Merion Township, PA — Officer Gary Temoyan passed away yesterday. Temoyan was a member of the Lower Merion Police Department, and a notice of his death was posted by both the Lower Meri... […]
- ALS walk at Miromar Outlets raises awareness for disease on February 15, 2019 at 8:59 pm
ALS (amyotrophic lateral sclerosis) Lou Gehrig’s disease is incurable. It’s a disease percussionist Trimble McCullough lives with every day. McCullough hopes Southwest Florida can help find a cure soo... […]
- Practice court at Hinkle named for Butler grad Matt White on February 14, 2019 at 3:09 pm
INDIANAPOLIS — A practice court at Hinkle Fieldhouse will be named in honor of a Butler University alumni who was an ardent fan and supporter despite battling ALS, also known as Lou Gehrig's disease. ... […]
- Brain Disease Market – Deep Research Study with Future State of the Competitive Landscape on February 11, 2019 at 4:24 am
ataxia and Lou Gehrig’s disease, which is another name for amyotrophic lateral sclerosis (ALS). WHO has already estimated a billion people to seek treatment for neurological disorders globally, yet th... […]
via Bing News