University of Alberta scientists find a new application for an existing drug, with potential to slow progression of the devastating degenerative disease.
A new drug could significantly slow the progression of ALS, also known as Lou Gehrig’s disease, according to new research by University of Alberta biologists. Current treatments slow progression of the degenerative disease by only a few months, and these findings could revolutionize the treatment of patients suffering from ALS, extending and improving quality of life.
The drug, called telbivudine, targets a protein that misfolds and does not function correctly in patients with ALS. “SOD1 is a protein that is known to misfold and misbehave in most cases of patients with ALS,” explained Ted Allison, associate professor in the Department of Biological Sciences and co-author on the study. “We showed that telbivudine can greatly reduce the toxic properties of SOD1, including improving the health of the subject’s motor neurons and improving movement.”
The research team used computer simulations to identify drugs with the potential for targeting the SOD1 protein. From this shortlist, the scientists identified and tested the most likely candidates—including telbivudine—using animal models.
“ALS is not well-understood,” said lead author Michele DuVal, who recently completed the PhD portion of the Faculty of Medicine & Dentistry’sMD/PhD program under the supervision of Allison. “We don’t yet know exactly what goes wrong first in the motor neurons or how the misbehaving SOD1 causes toxicity. Because there is still much to learn about the disease, the ALS research community focuses on both understanding ALS and on developing promising therapies.”
The discovery of telbivudine as a potential treatment is particularly exciting because the drug is already in use for treating patients with hepatitis. “It is already proven safe to use in patients, and it has very good potential for repurposing to use in a new clinical setting against ALS,” said Allison.
The Latest on: Lou Gehrig’s disease
via Google News
The Latest on: Lou Gehrig’s disease
- Top things to do in Cincinnati this weekend: Dec. 20-23 on December 19, 2018 at 11:24 pm
Northside Yacht Club, 4227 Spring Grove Ave., Northside. Come celebrate the life of DJ Harvination, who died from Lou Gehrig's disease in November. Many in the Queen City's music scene describe her as ... […]
- BIGBANG’s Seungri Makes Meaningful Donation To Help People With Lou Gehrig’s Disease on December 19, 2018 at 10:20 pm
BIGBANG’s Seungri has made a meaningful donation to help people with Lou Gehrig’s disease! According to the Seungil Hope Foundation, Seungri recently made a donation of 100 million won (approximately ... […]
- New drug could significantly slow progression of ALS, shows research on December 18, 2018 at 10:37 am
A new drug could significantly slow the progression of ALS, also known as Lou Gehrig's disease, according to new research by University of Alberta biologists. Current treatments slow progression of th... […]
- Silver Alert issued for missing Newton man with ALS on December 18, 2018 at 10:25 am
NEWTON — A 69-year-old Newton man with Lou Gehrig's disease, or ALS, is missing, according to local police. Officials have issued a Silver Alert for Ricky Bickerstaff, last seen Monday morning in Newt... […]
- Penn State Health creates OnDemand app for telemedicine on December 18, 2018 at 9:00 am
including ALS or Lou Gehrig's disease. The app is powered by American Well and was launched in September. It provides access to unlimited live video visits with doctors from any smartphone ... […]
- Genetic cause of ALS and frontotemporal dementia blocked by RNA-binding compound on December 18, 2018 at 7:18 am
ALS, short for amyotrophic lateral sclerosis, is also known as Lou Gehrig's disease in honor of the late baseball legend. An estimated 20,000 people in the United States currently live with the ... […]
- Biologists identify promising drug for ALS treatment on December 18, 2018 at 6:49 am
Credit: John Ulan A drug typically used to treat hepatitis could slow the progression of ALS, also known as Lou Gehrig's disease, according to new research by University of Alberta scientists. […]
- St. Helena community remembers Doug Ernst, Napa Valley journalist on December 17, 2018 at 1:00 pm
who passed away on Dec. 11 after a brief battle with ALS or Lou Gehrig’s disease. He was 64. Ernst was editor and publisher of the St. Helena Star from 2004-2011. A memorial service will be held ... […]
- Former Michigan hockey player, 40, dies from ALS on December 17, 2018 at 11:10 am
Former Michigan hockey player Scott Matzka died on Sunday at the age of 40. Matzka had been an advocate for awareness and research of ALS, commonly called Lou Gehrig's disease. Matzka, a Port Huron na... […]
- Tim Green’s ALS: Is it fair to blame football? on December 17, 2018 at 11:06 am
SYRACUSE, N.Y. – Tim Green recently disclosed on national TV he suspects repeated football-related head injuries caused his ALS, a fatal nervous system disorder also known as Lou Gehrig’s disease. The ... […]
via Bing News