Wide dissemination of colistin-resistant Escherichia coli, a growing therapeutic concern, in rural communities in Vietnam revealed
A team of researchers led by Osaka University examined the dissemination of colistin-resistant bacteria among residents of rural communities in Vietnam to find that the prevalence of colistin-resistant Escherichia coli (CR-E) in the intestines was extremely high, at about 70 percent.
This Escherichia coli (E. coli) is a non-pathogenic bacterium, so the residents have no symptoms, but the detection of this type of E. coli in developed countries has been infrequently reported. It was revealed that the prevalence of colistin-resistant bacteria in residents in Vietnam was extremely high and that colistin-resistant bacteria, whose clinical impact is a great concern in hospital settings, were spread in local communities in the developing country faster than expected.
The team’s research results were published in the Journal of Antimicrobial Chemotherapy.
Colistin, an old antibiotic discovered in 1950, kills or inhibits the growth of Gram-negative bacteria, such as E. coli and Pseudomonas aeruginosa. It is one of the few critical antibacterial drugs for treating multidrug-resistant bacteria and is listed on the WHO Essential Medicines List (EML) as a last-resort antibiotic.
Colistin-resistance is mostly related to chromosomal mutations. Although its frequency was low, a certain level of colistin-resistance was observed. However, since colistin-resistance caused by mutations was not transferred to other bacterial species, it was not considered problematic. However, a transmissible colistin resistance gene (mcr) was discovered in China in 2015 and the possibility of the transfer of colistin-resistance to other bacterial species was shown, becoming a global concern. This presents the potential danger that carriage of mcr1 gene in pathogens with other resistance genes will produce super drug-resistant bacteria called “Nightmare bacteria.” This bacteria exhibits resistance to all antibiotics, even to the last-resort antibiotic colistin, posing a great threat in infectious disease treatment.
Drug-resistant strains are spread in livestock and livestock products in developing countries. This group has pointed out that meat contains colistin-resistant bacteria because a large amount of colistin has been added to livestock food in Vietnam.
Thus, the group investigated the prevalence of colistin-resistant bacteria in Vietnam and revealed that the dissemination of colistin-resistant Escherichia coli (CR-E) in the faecal microbiota of residents was extremely high (70.4% of residents) and that CR-E had the transmissible colistin resistance gene (mcr).
First author Yoshimasa Yamamoto says, “CR-E carriers don’t cause health problems immediately, but it’s clear that the number of refractory infections for which antibiotics don’t work will increase, which will become a great menace to clinical practice. In this borderless society, drug-resistant bacteria quickly spread beyond national and regional borders, so it is necessary to strengthen international surveillance systems and promptly take preventative measures.”
The Latest on: Nightmare bacteria
via Google News
The Latest on: Nightmare bacteria
- Bacterial Resistance Spreading At Alarming Rate In Vietnam on December 31, 2018 at 6:37 pm
MCR1 is transmissible polymyxin E-resistant gene that has been found in China, raising concerns that resistance may be transferred to other bacterial species which could lead to super resistant nightm... […]
- Threat of 'nightmare bacteria' exhibiting resistance to last-resort antibiotic colistin on December 20, 2018 at 2:03 pm
Researchers examined the dissemination of colistin-resistant bacteria among residents of rural communities in Vietnam to find that the prevalence of colistin-resistant Escherichia coli in the intestin... […]
- Threat of 'nightmare bacteria' with resistance to last-resort antibiotic colistin on December 20, 2018 at 6:01 am
A team of researchers led by Osaka University examined the dissemination of colistin-resistant bacteria among residents of rural communities in Vietnam to find that the prevalence of colistin-resistan... […]
- 'Nightmare bacteria' on the rise on April 23, 2018 at 4:17 am
The term “nightmare bacteria” is definitely one meant to inspire a bit of fear. It refers to bacteria that is growing more resistant to antibiotics, more specifically carbapenem-resistant Enterobacter... […]
- CDC found over 220 cases of “nightmare bacteria” last year on April 6, 2018 at 12:11 pm
The Centers for Disease Control and Prevention detected more than 220 cases last year of a rare breed of “nightmare bacteria” that are virtually untreatable and capable of spreading genes that make th... […]
- 'Nightmare Bacteria' Found In NY: CDC on April 5, 2018 at 8:40 am
NEW YORK, NY — Antibiotic-resistant, often deadly "nightmare bacteria" infections were found more than 220 times last year in 27 states including New York, the U.S. Centers for Disease Control and Pre... […]
- 'Nightmare bacteria' found in 27 states, including Illinois, CDC says on April 4, 2018 at 3:32 pm
"Nightmare bacteria" with unusual resistance to antibiotics of last resort were found more than 200 times in the United States last year in a first-of-a-kind hunt to see how much of a threat these rar... […]
- Antibiotic-Resistant 'Nightmare Bacteria' Confirmed in 27 States, CDC Says on April 4, 2018 at 12:40 pm
The antibiotic-resistant germs are "virtually untreatable with modern medicine" and can "spread like wildfire". Each year, 23,000 Americans die from antibiotic-resistant germs. Of the germs tested by ... […]
- 'Nightmare bacteria' trying to spread in US, CDC warns of dangers on April 4, 2018 at 11:59 am
(CDC via AP, File) [ + - ] TAMPA (WFLA) - The CDC has a new warning about nightmare bacteria. It’s a bacteria with unusual resistance to antibiotics, and 50 percent of the people who contract it die. ... […]
- Drug-resistant ‘nightmare bacteria’ pose growing threat, CDC says on April 3, 2018 at 8:48 pm
That’s more than they had expected to find, and the true number is probably higher because the effort involved only certain labs in each state, officials say. The problem mostly strikes people in hosp... […]
via Bing News