Salk research focuses on the development of compounds that may protect against the diseases of aging, such as Alzheimer’s
Old age is the greatest risk factor for many diseases, including Alzheimer’s disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. New Salk research has now identified a unique subclass of these compounds, dubbed geroneuroprotectors (GNPs), which are AD drug candidates and slow the aging process in mice.
“The argument for geroprotectors is that if one can extend the lifespan of model organisms, such as mice, and translate this effect to humans, then you should be able to slow down the appearance of many diseases that are associated with aging, such as Alzheimer’s, Parkinson’s, cancer and overall frailty,” says first author Dave Schubert, Salk professor and head of Salk’s Cellular Neurobiology Laboratory.
The study, which appeared in the journal Trends in Pharmacological Sciences, on November 13, 2018, was conducted in collaboration with Salk Senior Staff Scientist Pamela Maher, whose lab is in the Cellular Neurobiology department and who is the study’s senior author.
The team started with two chemicals found in plants that have demonstrated medicinal properties: fisetin, a natural product derived from fruits and vegetables, and curcumin, from the curry spice turmeric. From these, the team synthesized three AD drug candidates based upon their ability to protect neurons from multiple toxicities associated with the aging brain. The lab showed that these three synthetic candidates (known as CMS121, CAD31 and J147), as well as fisetin and curcumin, reduced the molecular markers of aging, as well as dementia, and extended the median lifespan of mice or flies.
Importantly, the group demonstrated that the molecular pathways engaged by these AD drug candidates are the same as two other well-researched synthetic compounds that are known to extend the lifespan of many animals. For this reason, and based on the results of their previous studies, the team says fisetin, curcumin and the three AD drug candidates all meet the definition of being geroneuroprotectors.
The group is now focusing on getting two GNPs into human clinical trials. The fisetin derivative, CMS121, is currently in the animal toxicology studies required for FDA approval to start clinical trials. The curcumin derivative, J147, is under FDA review for allowance to start clinical trials for AD early next year. The group plans to incorporate biochemical markers for aging into the clinical trials to assay for potential geroprotective effects.
“Since we found that the natural products curcumin and fisetin are also GNPs and commercially available as supplements, they could provide some therapeutic benefits right now,” says Maher.
Other studies in the lab are determining whether these compounds have effects on organs outside of the brain. “If these drugs have benefits for other body systems, such as maintaining kidney function and overall muscle health, they could be used in additional ways to treat or prevent the diseases of aging,” Schubert says.
The investigators say that the discovery of these AD drug candidates validates the drug discovery model they have developed as a plausible method for identifying additional GNP compounds that will help promote healthy aging. This could greatly accelerate the pipeline for drugs to treat the diseases of aging for which there are currently no cures.
The Latest on: Anti-aging
via Google News
The Latest on: Anti-aging
- Anti-Aging Ingredient Market Forecast Highlights Revenue Share Analysis Across Prime Geographies During the Forecast Period 2018 to 2028 on April 17, 2019 at 1:19 am
Rockville, MD -- (SBWIRE) -- 04/17/2019 -- The factors driving the global anti-aging ingredients market are increasing the demand for nutrients in the diet and antioxidants. These type of ingredients ... […]
- Anti-Aging Drug Reduces Risk Of Age Related Diseases on April 16, 2019 at 5:40 pm
Not only can an anti-aging drugs make a person look young(er) for their age, they can also help to reduce the risks of having health conditions such as heart disease, cancer, arthritis, diabetes, and ... […]
- The global anti-aging services market size is likely to reach USD 35.43 billion by 2026 on April 16, 2019 at 2:24 pm
NEW YORK, April 16, 2019 /PRNewswire/ -- Anti-aging Services Market Size, Share & Trends Analysis Report By Demographics, By Type (Chemical Peel, BOTOX, Microdermabrasion, Breast Augmentation, ... […]
- This anti-aging tinted moisturizer has over 2,500 rave reviews — here's why everyone loves it on April 16, 2019 at 12:43 pm
Laura Mercier’s best selling product is a tinted moisturizer that goes above and beyond to deliver anti-aging benefits and sun protection. And who doesn’t love a multitasking beauty product? Over ... […]
- Walnuts as the Best Anti-Aging Food to Make You Look and Feel Younger on April 15, 2019 at 8:34 pm
All these mentioned have antioxidant properties, which not only rid of toxins in the body but can also help clear the skin and prevent chronic illnesses. Walnuts indeed have high levels of ... […]
- Anti-Aging Discovery Could Lead to Restorative Skin Treatments on April 15, 2019 at 1:31 pm
Despite a multi-billion-dollar skin care industry and plenty of marketing claims, nothing exists that can prevent our skin from turning into tissue paper as we age — except, perhaps ... […]
- Anti-Aging from the Neck Down on April 15, 2019 at 8:20 am
When it comes to anti-aging treatments, most products seem to focus solely on the face. But who doesn’t want their whole body to look as good as their face? Joining us to discuss their new Anti-Aging ... […]
- Lira Clinical Introduces PRO Anti-Aging Pads, A Revolutionary At-home Treatment for Professional Skin Brightening and Exfoliating on April 15, 2019 at 5:50 am
Lira Clinical's New PRO Anti-Aging Pads come in a 3 oz jar containing 40 pads, enough for two months. DUBLIN, Calif., April 15, 2019 (GLOBE NEWSWIRE) -- Lira Clinical, the global leader in skin ... […]
- Anti-aging Services Market Size to Reach $35.43 Billion by 2026 | CAGR: 5.3%: Grand View Research, Inc. on April 15, 2019 at 3:24 am
SAN FRANCISCO, April 15, 2019 /PRNewswire/ -- The global anti-aging services market size is likely to reach USD 35.43 billion by 2026, according to a new report by Grand View Research, Inc ... […]
via Bing News