Diabetic foot ulcers can take up to 150 days to heal. A biomedical engineering team wants to reduce it to 21 days.
They’re planning to drop the healing time by amplifying what the body already does naturally: build layers of new tissue pumped up by nitric oxide. In patients with diabetes, impaired nitric oxide production lessens the healing power of skin cells, and the Centers for Disease Control reports that 15 percent of Americans living with Type 2 diabetes struggle with hard-to-heal foot ulcers. However, simply pumping up nitric oxide is not necessarily better. The long-term plan of Michigan Technological University researchers is to create nitric oxide-infused bandages that adjust the chemical release depending on the cell conditions.
To do that, the researchers first have to figure what’s going on with nitric oxide in skin cells. Assessing nitric oxide under diabetic and normal conditions in human dermal fibroblast cells is the focus of the team’s latest paper, published this week in Medical Sciences (DOI: 10.3390/medsci6040099).
Cell-mediated Symphony of Complexity
Megan Frost is the interim chair of the Department of Kinesiology and Integrative Physiology as well as an associate professor of biomedical engineering and an affiliated associate professor of materials science and engineering. She runs a polymeric biomaterials lab at Michigan Tech where she works on nitric oxide-releasing technology.
“Nitric oxide is a powerful healing chemical, but it’s not meant to be heavy-handed,” Frost says. “We’re looking at the profiles of healthy and diabetic cells to find a more nuanced way to recover wound function.”
As a wound heals, three types of skin cells step in. Macrophages are the first responders—and the most widely studied cells—that arrive within 24 hours of damage. Next, fibroblasts arrive, which are like the body’s engineers. They help lay down the extracellular matrix that makes it possible for the next cells, keratinocytes, to do the heavy-lifting and rebuilding.
“Wound healing is a complex, cell-mediated symphony of events, progressing through a series of predictable and overlapping stages,” Frost and her team write in their Medical Sciences paper. When any part of that orchestra is out of tune, the whole process falls flat. Fibroblasts, which are not as well studied as macrophages in the healing process, are a key instrument, and past studies have shown their delayed response in patients with diabetes may be a major factor in slow healing time.
Nitric Oxide vs. Nitrite
That’s where nitric oxide steps in, a kind of chemical metronome to get the process back into the right rhythm. But the body’s dermal orchestra is not so simple—just as playing a metronome louder and louder isn’t necessarily going to make a musician’s timing improve, flooding a wound with nitric oxide isn’t a cure-all.
“The old approach is to add nitric oxide and sit back to see if it works,” Frost says. “What we’re finding is that it’s not enough to apply and leave; we have to keep tabs on how much nitric oxide is actually needed.”
A big problem that Frost and her team address is how nitric oxide is measured in the first place. Current practice substitutes measuring nitrite for nitric oxide—a misleading switch, Frost says, because nitrite is a byproduct with no time signature. While stable nitrite is easier to measure, by itself it cannot relay the real-time healing status like nitric oxide levels can.
So, Frost’s lab built a nitric oxide-measuring device for their study by hand. That creates a challenge since it means taking measurements is much harder, which limits the dataset size, but Frost has an agreement with Zysense LLC to streamline the building process and produce commercial nitric oxide measurement devices that would improve cell chemistry research.
Collaboration is a key part of the engineering design process. To build a nitric oxide bandage with personalized healing power, the team plans to work next with the UP Portage Health System to gather cell samples from local patients. By expanding their cell samples—and applying the tech to real-world patients—the team will continue to broaden their database while deepening their knowledge of nitric oxide mechanisms.
In a few years, they plan to have a working bandage prototype, one that leaves off the clunky nitrite proxies and nitric oxide dumps. Instead, patients dealing with diabetic foot ulcers will see a light at the end of the tunnel much sooner than half a year or more—the nitric oxide-releasing bandage could help heal one of health care’s toughest diseases in less than a month.
The Latest on: Diabetic ulcers
via Google News
The Latest on: Diabetic ulcers
- BF&M commits $28,000 to diabetes projecton October 8, 2020 at 12:06 pm
BF&M Ltd has committed $28,000 to fund a pilot programme designed to assist in the prevention, treatment and rehabilitation for those living with diabetic foot disease. The insurer is partnering with ...
- BF&M Commits $28K To Diabetes Pilot Projecton October 8, 2020 at 11:44 am
“The program will provide 10 of BF&M’s health clients who are suffering with diabetic foot disease [foot ulcers] with two new revolutionary products, PulseFlowDf and FootForte. These products ...
- Centaur Pharma launches novel topical solution WoxHeal for the treatment of Diabetic Foot Ulceron October 8, 2020 at 2:37 am
Diabetes develop a Diabetic Foot Ulcer • 1 in 5 people developing severe infection undergo foot amputation • Developed with German technology partner – CytoTools AG • Will help save millions of foot ...
- 25% people with Diabetes develop a Diabetic Foot Ulcer, says WHOon October 6, 2020 at 5:52 am
A globally patented product, WOXheal® topical solution, is effective in treating Diabetic foot ulcers, company claims.
- Common heartburn meds linked to higher diabetes riskon October 2, 2020 at 10:43 pm
Often-used drugs called proton pump inhibitors, or PPIs, ease heartburn symptoms, but a new study suggests they might also increase the risk of type 2 diabetes.
- NavCare and Orpyx® Provide Turn-Key Telehealth Solution to Help Prevent Diabetic Foot Ulcers and Amputationson October 1, 2020 at 6:38 am
NavCare, an industry leader in the delivery of comprehensive care management services, and Orpyx® Medical Technologies, an innovator in digital health therapeutics have partnered to provide a turn-key ...
- Poor immune response impairs diabetic wound healingon September 29, 2020 at 12:28 pm
Researchers found that diabetic foot ulcers don’t recruit the immune cells necessary for normal wound healing. The study also identified potential targets for future therapies.
- Royal Biologics Completes 100th Cyro Cord™ Case, Successfully Enrolls First Patient Into Diabetic Foot Ulcer Studyon September 29, 2020 at 6:02 am
PRNewswire/ -- Royal Biologics, an ortho-biologics company specializing in the research and advancement of novel ortho-biologics solutions, today announced the 100th successful implantation of ...
- Diabetic Foot Ulcers Treatment Market Industry Share, Growth Drivers and Sales Revenue|M Healthcare, Smith & Nephew Plc. and Molnlycke Health Care ABon September 29, 2020 at 12:42 am
MarketResearch.Biz :Diabetic Foot Ulcers Treatment Market Overview: The report provides each quantitative and qualitative information of the global Diabetic Foot Ulcers Treatment market for the period ...
via Bing News