Researchers at The University of Texas at Arlington have found a potential new pathway to regulate immune response and potentially control inflammatory diseases of the central nervous system such as meningitis and sepsis.
“We need to know what turns on inflammatory response to bacterial infection to be able to modulate the process,” said Subhrangsu Mandal, the UTA associate professor of chemistry who led the research.
“If we can do so, we can control inflammatory diseases of the central nervous system that have been hard to treat up to now, such as sepsis and meningitis, as well as cancer and muscular dystrophy, which can also be seen a kind of inflammation,” he added.
Mandal and his team’s research findings were published in Scientific Reports.
The researchers have found that the long non-coding RNA molecule HOTAIR present in white blood cells has the capacity to signal these cells to activate immune response in the presence of bacteria. RNA, or ribonucleic acid, is present in all living cells. Its primary role is to carry instructions from DNA.
“Knowing that HOTAIR has a role in the signaling pathway also means that we can use it as a biomarker for bacterial infection,” he added. “Simple blood tests could indicate infection much more quickly, enabling better treatment for patients of rapidly-moving diseases such as septic shock and meningitis, which have been hard to treat up to now.”
The researchers used the resources of UTA’s North Texas Genome Center to demonstrate that noncoding RNA expression – including HOTAIR – is induced in white blood cells treated with lipopolysaccharide, which are molecules found on the outer membrane of bacterial cells. The research showed that HOTAIR gene was expressed alongside cytokines, which are excreted by cells as part of immune response, and inflammatory response genes such as iNOS. As a result, it is possible to conclude that HOTAIR is a key regulator for pathogen-induced cytokine expression, immune response and inflammation.
“Long non-coding RNAs like HOTAIR are emerging as key regulators of cell signaling processes and many are expressed in immune cells and play a critical role in immune response,” Mandal said. “Previous research carried out with Marco Brotto in UTA’s College of Nursing and Health Innovation had already established a link between low flow of oxygen to tissues and HOTAIR, which has been linked to cancer.”
“Having a resource like the North Texas Genome Center really means that we can multiply our work looking at non-coding RNAs in general, a burgeoning field in biochemistry,” he added.
Fred MacDonnell, UTA chair of chemistry and biochemistry, congratulated Mandal on this new research.
“Basic science related to the pathways for immune response is critical as there have been very few successes up to now developing treatments for extreme inflammations like sepsis and meningitis, “ MacDonnell said.
The Latest on: Immune response
via Google News
The Latest on: Immune response
- Severe COVID-19 infection linked to overactive immune cellson October 8, 2020 at 9:55 am
Samples from the lungs of patients show a runaway immune system reaction could be one mechanism behind severe COVID-19 cases.
- Blocking immune system pathway may stop COVID-19 infection, prevent severe organ damageon October 8, 2020 at 9:49 am
While the world waits eagerly for a safe and effective vaccine to prevent infections from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus behind the COVID-19 pandemic, ...
- An autoimmune-like antibody response is linked with severe COVID-19on October 8, 2020 at 9:20 am
We were wrong. Several months into studying COVID-19, like other scientists, I’ve come to realize the picture is far more complicated. A recent research study published by my colleagues and me adds ...
- Proteolytic cleavage of nucleocapsid helps SARS-CoV-2 evade host immune responseson October 7, 2020 at 6:30 pm
A team of scientists of the University of Oxford reveals that the nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) undergoes autoproteolysis, and that resulting ...
- Boosting chickens' own immune response could curb diseaseon October 7, 2020 at 1:21 pm
Broiler chicken producers the world over are all too familiar with coccidiosis, a parasite-borne intestinal disease that stalls growth and winnows flocks. Various approaches, developed over decades, ...
- IL-21 protein is a major part of immune response to chronic infections in the central nervous systemon October 5, 2020 at 10:52 pm
Researchers at Penn State College of Medicine now better understand the role of a protein, interleukin-21 (IL-21), in the immune system response to infections in the nervous system.
- Charting a Covid-19 Immune Responseon October 5, 2020 at 2:14 pm
The coronavirus can be a tricky adversary — and for many people whose cases of Covid-19 are severe, the greatest threat to survival might not be the pathogen itself, but the deadly forces that the ...
- Trump’s Covid-19 Treatment Seeks to Boost Immune Responseon October 5, 2020 at 12:55 pm
The experimental infusion doctors have given to President Trump seeks to counter a problem affecting many older Covid-19 patients: an ineffective immune response.
- St. Jude leverages workforce for research on COVID-19 immune responseon October 2, 2020 at 10:00 pm
St. Jude Children’s Research Hospital made a commitment early in the pandemic to test all its employees regularly for COVID-19 regardless of symptoms. The tactic has enabled the institution to be a ...
via Bing News