There just aren’t enough kidney transplants available for the millions of people with renal failure.
Aside from a transplant, the only alternative for patients is to undergo regular dialysis sessions to clear harmful cellular waste from their bodies. Now, scientists report in ACS Nanoa new urea sorbent that could accelerate progress toward the development of a lightweight, wearable artificial kidney with the potential to make dialysis more convenient, comfortable and effective.
Dialysis typically requires three visits every week to a health care center, where patients are tethered to a machine for hours. Not only is this cumbersome, but health outcomes with the treatment are poor. The problem is that kidneys filter blood around the clock; dialysis just can’t do as good of a job when performed for only a few times each week. Scientists are eager to develop an artificial kidney that could be worn all the time, continuously performing dialysis. One obstacle, though, is urea, which must be removed to maintain the body’s nitrogen balance. Currently, dialysis deals with urea using an enzyme that breaks the molecule down into ammonia and carbon dioxide, but the amount of material required to perform this reaction is too big and heavy to be comfortably worn on the body. So, Babak Anasori, Yury Gogotsi and colleagues wanted to try a new approach.
The researchers turned to an emerging nanomaterial called MXene, two-dimensional nanosheets of metal carbides. Instead of breaking down urea, MXene can capture the compound by sandwiching urea molecules between its nanometer-thin layers. At room temperature, the material could capture 94 percent of urea from the discarded materials from dialysis machines. When tested at body temperature (98.6 F), the material could hold onto even more urea. Furthermore, MXene did not kill cells, suggesting that it could be safely used in people. The researchers conclude that the material could help turn the concept of a comfortably wearable artificial kidney into a reality.
Learn more: Taking steps toward a wearable artificial kidney
The Latest on: Wearable artificial kidney
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The Latest on: Wearable artificial kidney
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- Behind the Invention: Wearable Artificial Kidney on February 6, 2019 at 8:47 am
Victor Gura, MD, inventor of the Wearable Artificial Kidney, spoke at MD&M West about design considerations, obstacles, and goals involved with developing a portable dialysis device. Sepsis is one of ... […]
- At MD&M West: A Future in Wearable Organs on February 5, 2019 at 10:14 pm
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- Dialysis Equipment Market to Register a Strong Growth of US$ 23.6 Bn by 2028 on January 29, 2019 at 5:06 pm
In a new development, the Kidney Research Institute of the University of Washington is currently developing a wearable artificial kidney that is expected to go into clinical trials in 2022. This could ... […]
- Standing in for a Kidney, MXene Materials Could Give Dialysis Patients the Freedom to Move on November 4, 2018 at 4:00 pm
This means it could one day make the wearable kidney a reality, improving quality of life for many people.” With its atom-thin layers, MXene could be an effective filter for urea in wearable artificia... […]
- Taking steps toward a wearable artificial kidney on October 17, 2018 at 8:13 am
There just aren't enough kidney transplants available for the millions of people with renal failure. Aside from a transplant, the only alternative for patients is to undergo regular dialysis sessions ... […]
- Dialysis Equipment Market Likely to Reach a Valuation of US$ 23.6 Bn by 2028 End - Future Market Insights on June 21, 2018 at 1:30 am
(Logo: https://mma.prnewswire.com/media/677274/Future_Market_Insights_Logo.jpg) In a new development, the Kidney Research Institute of the University of Washington is currently developing a wearable a... […]
- Artificial kidney goes on clinical trial in Germany on April 9, 2018 at 11:20 pm
A German hospital has begun collaboration with a Singapore-based company on a wearable artificial kidney for children suffering from renal diseases. The clinical trials will take place in University C... […]
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