There just aren’t enough kidney transplants available for the millions of people with renal failure.
Aside from a transplant, the only alternative for patients is to undergo regular dialysis sessions to clear harmful cellular waste from their bodies. Now, scientists report in ACS Nanoa new urea sorbent that could accelerate progress toward the development of a lightweight, wearable artificial kidney with the potential to make dialysis more convenient, comfortable and effective.
Dialysis typically requires three visits every week to a health care center, where patients are tethered to a machine for hours. Not only is this cumbersome, but health outcomes with the treatment are poor. The problem is that kidneys filter blood around the clock; dialysis just can’t do as good of a job when performed for only a few times each week. Scientists are eager to develop an artificial kidney that could be worn all the time, continuously performing dialysis. One obstacle, though, is urea, which must be removed to maintain the body’s nitrogen balance. Currently, dialysis deals with urea using an enzyme that breaks the molecule down into ammonia and carbon dioxide, but the amount of material required to perform this reaction is too big and heavy to be comfortably worn on the body. So, Babak Anasori, Yury Gogotsi and colleagues wanted to try a new approach.
The researchers turned to an emerging nanomaterial called MXene, two-dimensional nanosheets of metal carbides. Instead of breaking down urea, MXene can capture the compound by sandwiching urea molecules between its nanometer-thin layers. At room temperature, the material could capture 94 percent of urea from the discarded materials from dialysis machines. When tested at body temperature (98.6 F), the material could hold onto even more urea. Furthermore, MXene did not kill cells, suggesting that it could be safely used in people. The researchers conclude that the material could help turn the concept of a comfortably wearable artificial kidney into a reality.
Learn more: Taking steps toward a wearable artificial kidney
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The Latest on: Wearable artificial kidney
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The Latest on: Wearable artificial kidney
- Standing in for a kidney, MXene materials can be used to filter urea, could give dialysis patients the freedom to move on November 5, 2018 at 9:13 pm
The authors, among them Victor Gura, MD, from Cedars Sinai Medical Center and UCLA's David Geffen School of Medicine, who developed the first wearable artificial kidney technology, note that more freq... […]
- Standing in for a Kidney, MXene Materials Could Give Dialysis Patients the Freedom to Move on November 5, 2018 at 7:45 am
This means it could one day make the wearable kidney a reality, improving quality of life for many people.” With its atom-thin layers, MXene could be an effective filter for urea in wearable artificia... […]
- Global Dialysis Equipment Market Is Projected to Register a CAGR of 4.8% and Will Likely Reach a Valuation of US $23.6 Bn by 2028 End on October 30, 2018 at 5:00 pm
In a new development, the Kidney Research Institute of the University of Washington is currently developing a wearable artificial kidney that is expected to go into clinical trials in 2022. This could ... […]
- Taking steps toward a wearable artificial kidney on October 17, 2018 at 8:13 am
There just aren't enough kidney transplants available for the millions of people with renal failure. Aside from a transplant, the only alternative for patients is to undergo regular dialysis sessions ... […]
- The wearable kidney on August 25, 2018 at 5:00 pm
A fashion statement it may not be, but the Wearable Artificial Kidney (WAK) could prove a very smart accessory for those with serious kidney disease. A miniaturized dialysis machine that can be worn a... […]
- Artificial kidney goes on clinical trial in Germany on April 9, 2018 at 11:20 pm
A German hospital has begun collaboration with a Singapore-based company on a wearable artificial kidney for children suffering from renal diseases. The clinical trials will take place in University C... […]
- The First Wearable Artifical Kidney Might Free People From Dialysis Machines on March 28, 2018 at 5:42 pm
But it’s also cumbersome, expensive, and a high-risk procedure. That’s where the wearable artificial kidney comes into play. The wearable artificial kidney uses the principles of dialysis, but it’s co... […]
- Forget dialysis, transplants, artificial organs can be key on March 8, 2017 at 9:16 pm
"When ready, it is expected to replace the donor kidney, which usually requires a long waiting period," he says. Dr Dilip M Babu, consultant nephrologist at Apollo Hospitals, Hyderguda, says the 'wear... […]
- Coming Soon: A Wearable Artificial Kidney? on June 7, 2016 at 11:42 am
TUESDAY, June 7, 2016 (HealthDay News) - Someday, dialysis patients might free themselves of clunky machines, moving about with a "wearable artificial kidney" instead. That's the promise of a new clin... […]
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