According to the National Institute of Mental Health (NIMH), 4.4 percent of the population of the United States will have bipolar disorder at one point in their lives.
While the precise causes of such, often debilitating, psychiatric conditions remain unknown, scientists do know that both genes and the environment play a role.
New research that now appears in the journal Frontiers in Microbiology highlights the fact that environmental factors such as viruses may be the driving force behind these disorders.
An international team of scientists led by Bhupesh Prusty — from the Department of Microbiology at the University of Würzburg in Germany — discovered that in the brains of people who lived with bipolar and major depression, a class of neurons called Purkinje cells was infected with the herpesvirus HHV-6A.
Purkinje neurons are inhibitory brain cells located in the human cerebellum, which is the brain area responsible for controlling movement, muscles, balance, and posture.
However, some research has also tied this brain region to language, cognition, and mood.
How HHV-6 may cause depression, bipolar
Prusty and team started from the hypothesis that the human herpesviruses HHV-6A and HHV-6B may drive the development of psychiatric disorders.
So, they examined two large cohorts of brain biopsies from the Stanley Medical Research Institute in Kensington, MD.
“We were able to find active infection of HHV-6 predominantly within Purkinje cells of human cerebellum in bipolar and major depressive disorder patients,” Prusty reports.
The Latest on: Herpesvirus HHV-6A
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The Latest on: Herpesvirus HHV-6A
- Herpes virus link to bipolar disorder and depression on September 28, 2018 at 1:13 am
Prusty and his team suspected the human herpes viruses HHV-6A and HHV-6B to play a key role in the genesis ... which shows that Alzheimer’s disease can also be caused by human herpes virus 6A. In the ... […]
- Disease Mechanisms-Alzheimer's Disease on July 18, 2018 at 5:00 pm
In the paper, researchers reported finding levels of two herpes genes — human herpes virus 6A (HHV-6A) and human herpes virus 7 (HHV-7) — to be more abundant in Alzheimer brain tissue than in age-matc... […]
- Can herpes virus cause Alzheimer's disease? on June 23, 2018 at 3:07 am
The study found unusually increased level of human herpesvirus named human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7 ) in the brains of the people with Alzheimer's than those without the ... […]
- Herpes Viruses Linked to Alzheimer's Disease in New Brain Research on June 22, 2018 at 7:21 am
And of all the viruses they looked at, there were two that showed the strongest connection to Alzheimer’s: human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7). “That was just the beginning o... […]
- New study suggests viral connection to Alzheimer’s disease on June 21, 2018 at 8:52 am
The study identifies high levels of human herpesvirus (HHV) 6A and 7 in brain samples showing signs of AD neuropathology, compared with the lower levels found in normal brains. Further, through the ca... […]
- Unusually High Levels Of Herpes Viruses Found In The Alzheimer’s Disease Brain on June 21, 2018 at 8:11 am
Two strains of human herpes virus–human herpes virus 6A (HHV-6A) and human herpes virus 7 (HHV-7) –are found in the brains of people with Alzheimer’s disease at levels up to twice as high as in those ... […]
- Scientists Find High Levels of Two Herpesvirus Strains in Brains of Alzheimer’s Disease Patients on June 21, 2018 at 8:07 am
To evaluate the robustness of their findings, the team incorporated a further 800 RNA sequencing samples, observing a persistent increase of HHV-6A and HHV-7 abundance ... and Clinical Networks by Hum... […]
- Obscure virus found in women with unexplained infertility on July 7, 2016 at 6:34 am
A new study has found that the little-known member of the human herpesvirus family called HHV-6A infects the lining of the uterus in 43% of women with unexplained infertility but cannot be found in ut... […]
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