Venomous snakebites affect 2.5 million people, and annually cause more than 100,000 deaths and leave 400,000 individuals with permanent physical and psychological trauma each year. Researchers reporting in PLOS Neglected Tropical Diseases have now described a new approach to treating snake bites, using nanoparticles to bind to venom toxins and prevent the spread of venom through the body.
The standard treatment for snakebites is the intravenous administration of IgG immune molecules that recognize venoms. However, such antivenom therapies must be administered quickly–and by trained healthcare workers– to be effective and are highly specific to particular venoms. There is an ongoing need for a snakebite treatment which can be used in a rural setting and works against the bites of diverse venomous snakes.
In the new work, Kenneth Shea, of the University of California, Irvine, and colleagues engineered nanoparticles that bind to and sequester an array of phospholipases A2 (PLA2)and three-finger toxin (3FTX) molecules found in Elapidae snake venoms. The Elapidae family is a large family of venomous snakes that includes cobras, kraits, tiger snakes, sea snakes, coral snakes and mambas, among other species. The researchers tested the ability of the nanoparticles to block Naja nigricollis (black-necked spitting cobra) venom in mice that received varying doses of the nanoparticles, injected into the skin. Envenomings by this snake in sub-Saharan Africa inflict serious cutaneous necrosis that may leave permanent tissue damage in the victims.
In experiments on isolated cells, the nanoparticles were found to sequester a wide range of Elapidae PLA and 3FTX venoms. Moreover, with collaborator José María Gutiérrez from the Instituto Clodomiro Picado (Universidad de Costa Rica), experiments with mice demonstrated that injections of the nanoparticles at the site of venom injection significantly mitigated the typical necrotic effects–including blistering and ulcers– of the spitting cobra venom. The nanoparticles administered to mice that had not received venom did not have an effect on skin and did not induce systemic toxicity.
“The stable, low-cost nanoparticles have the potential to be administered subcutaneously immediately after the bite at the site of envenoming by this spitting cobra to halt or reduce the extent of local damage and mitigate the systemic distribution of toxins post-envenoming,” the researchers say.
Learn more: Nanoparticles to treat snakebites
Receive an email update when we add a new SNAKEBITES article.
The Latest on: Snakebites
via Google News
The Latest on: Snakebites
- Jacksonville poison control center sees surge in snakebite calls on October 5, 2018 at 6:55 pm
"This past weekend, the poison center in Florida had 14 snakebites reported that we were managing at that point in time," Schauben said. "We continue through this week to have several more." He said t... […]
- This App Is Saving Thousands of Snakes (and Humans) in India on October 5, 2018 at 9:18 am
That's why mapping out snakes is crucial to preventing snakebites. "We are talking about snakes killing people. But we don't know much about the distribution patterns of snakes in the country," Louies ... […]
- Researchers use nanoparticles to treat snake bites on October 5, 2018 at 7:50 am
Venomous snakebites affect 2.5 million people, and annually cause more than 100,000 deaths and leave 400,000 individuals with permanent physical and psychological trauma each year. Researchers reporti... […]
- A British Man Has Died From A Sea Snake Bite While Fishing In Australia on October 4, 2018 at 11:25 pm
His body was taken to the mainland town of Borroloola. Deaths from sea snake bites are rare, despite their deadly venom, due to their extremely limited contact with humans. The Marine Education Societ... […]
- Nanoparticles: New Approach to Treat Snakebites on October 4, 2018 at 1:45 pm
Scientists have used nanoparticles to bind to snake venom toxins and prevent the spread of venom through the body. The findings of the study are published in Neglected Tropical Diseases. The standard ... […]
- New Weapon Against Gruesome Venomous Snakebites Is Invisible to the Eye on October 4, 2018 at 11:18 am
When it comes to venomous snake bites, time is tissue. Even non-fatal snake bites still rapidly kill skin and muscle in a gruesome process called necrosis, often leaving victims permanently disfigured ... […]
- Nanoparticles to treat snakebites on October 4, 2018 at 11:02 am
"Synthetic polymer nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis." Credit: Shea, et al. Venomous snakebites affect 2.5 million people, and annually cause ... […]
- Snake bites 5th-grader from Plano ISD at Collin County Adventure Camp on October 3, 2018 at 7:42 am
A Plano ISD student was bitten by a snake Tuesday morning at a camp in Collin County, a school district spokeswoman said. The fifth-grade student at Shepard Elementary was walking near trails at the Y... […]
- Snake bites passenger on train in UP on September 30, 2018 at 7:42 pm
KANPUR: A passenger on board the Meerut-bound Sangam Express was bitten by a snake on the intervening night of Friday and Saturday. The incident led to panic in the packed coach of the train. […]
via Bing News