Spinal cord stimulation and physical therapy have helped a man paralyzed since 2013 regain his ability to stand and walk with assistance. The results, achieved in a research collaboration between Mayo Clinic and UCLA, are reported in Nature Medicine.
With an implanted stimulator turned on, the man, Jered Chinnock, was able to step with a front-wheeled walker while trainers provided occasional assistance. He made 113 rehabilitation visits to Mayo Clinic over a year, and achieved milestones during individual sessions:
- Total distance: 111 yards (102 meters) — about the length of a football field
- Total number of steps: 331
- Total minutes walking with assistance:16 minutes
- Step speed: 13 yards per minute (0.20 meters per second)
“What this is teaching us is that those networks of neurons below a spinal cord injury still can function after paralysis,” says Kendall Lee, M.D., Ph.D., co-principal investigator, neurosurgeon and director of Mayo Clinic’s Neural Engineering Laboratories.
In the study, Chinnock’s spinal cord was stimulated by an implanted electrode, enabling neurons to receive the signal that he wanted to stand or step.
“Now I think the real challenge starts, and that’s understanding how this happened, why it happened, and which patients will respond, says Kristin Zhao, Ph.D., co-principal investigator and director of Mayo Clinic’s Assistive and Restorative Technology Laboratory.
Currently, as a safety precaution, Chinnock takes steps only under the supervision of the research team.
Chinnock, now 29, injured his spinal cord at the thoracic vertebrae in the middle of his back in a snowmobile accident in 2013. He was diagnosed with a complete loss of function below the spinal cord injury, meaning he could not move or feel anything below the middle of his torso.
In the study, which began in 2016, Chinnock participated in 22 weeks of physical therapy and then had an electrode surgically implanted by Dr. Lee and his Mayo Clinic neurosurgery team.
The implant sits in the epidural space — the outermost part of the spinal canal — at a specific location below the injured area. The electrode connects to a pulse generator device under the skin of Chinnock’s abdomen and communicates wirelessly with an external controller. Mayo Clinic received permission from the U.S. Food and Drug Administration to use the device for a condition not covered by its FDA-approved label.
The research team then tried to determine if Chinnock could stand and walk with assistance. During 113 rehabilitation sessions, the researchers adjusted stimulation settings, trainer assistance, harness support and speed of the treadmill to allow him maximum independence.
The research demonstrated that Chinnock was able to walk over ground using a front-wheeled walker and step on a treadmill placing his arms on support bars to help with balance. However, when stimulation was off, Chinnock remained paralyzed.
In the first week, Chinnock used a harness to lower his risk of falling and to provide upper body balance. Trainers were positioned at his knees and hips to help him stand, swing his legs and shift his weight. Because Chinnock did not regain sensation, he initially used mirrors to view his legs, and trainers described leg position, movement and balance. By week 25, he did not need a harness, and trainers offered only occasional help. By the end of the study period, he learned to use his entire body to transfer weight, maintain balance and propel forward, requiring minimal verbal cues and periodic glances at his legs.
The Latest on: Spinal cord stimulation
via Google News
The Latest on: Spinal cord stimulation
- Spinal Cord Stimulation Market to Exhibit 8.1% CAGR, Rising Willingness to Spend on Quality Healthcare Services to Fuel Demand Forecast Till 2026 on June 14, 2019 at 9:50 am
Pune, India -- (SBWIRE) -- 06/14/2019 -- The Global Spinal Cord Stimulation Market is expected to gain from increasing per capita income. Recently Fortune Business insights, published a report, titled ... […]
- Spinal Cord Stimulation Market Research 2019, Business Opportunity, Global Trend, Future Growth, Key Findings and Forecast to 2023 on June 14, 2019 at 1:51 am
Jun 14, 2019 (The Expresswire via COMTEX) -- The Global Spinal Cord Stimulation Market was worth US$ 2,268.9 Mn in 2018. The global market is anticipated to progress at a CAGR of 8.1% and value US$ ... […]
- Nuvectra seeks another FDA nod for spinal cord stimulation system on June 12, 2019 at 8:07 am
Nuvectra said yesterday that it filed for expanded FDA approval of its Algovita spinal cord stimulation device. The Plano, Texas-based company asked the federal safety watchdog for full-body ... […]
- The Daily Biotech Pulse: Nuvectra Files For Expanded Label For Algovita SCS, Axovant Earnings, FDA Nod For Aratana on June 12, 2019 at 7:50 am
Scaling The Peaks Down In The Dumps Stock In Focus Nuvectra Files For Approval For Spinal Cord Stimulation System Medical device company Nuvectra Corp (NASDAQ: NVTR) filed its regulatory ... […]
- Boston Scientific Corporation: Boston Scientific Closes Acquisition Of Vertiflex, Inc. on June 11, 2019 at 3:30 pm
The acquisition of Vertiflex adds the only FDA-approved, commercially-available, minimally-invasive interspinous spacer to the industry-leading pain management portfolio from Boston Scientific, which ... […]
- Global Neurostimulation Devices Market Set to Reach USD 12.2 Billion by 2024, Witnessing a CAGR of 11.2% during the Forecast Period: VynZ Research on June 11, 2019 at 1:59 am
The internal neurostimulation segment is further segmented into spinal cord stimulation, deep brain stimulation, vagus nerve stimulation, sacral nerve stimulation, cochear implant and gastric ... […]
- Healthbeat: Bluetooth DRG pain control on June 8, 2019 at 12:31 pm
In a randomized trial, 74 percent of patients reported meaningful pain relief, compared to 53 percent who got standard dorsal column spinal cord stimulation. The DRG stimulator is FDA approved. ... […]
- Kessler Foundation receives $1M donation to fund 3 studies for spinal cord injuries on June 7, 2019 at 12:42 pm
Three insights: 1. CSS will study two treatments for recovery after spinal cord injury, transcutaneous and epidural spinal stimulation, which both apply electrical stimulation to the spinal cord to ... […]
- Kessler Foundation receives $1 million gift to study groundbreaking treatments for spinal cord injury on June 7, 2019 at 12:33 am
Mr. Reynolds sustained a spinal cord injury in 2000 as a passenger in a motor vehicle accident, and underwent rehabilitation at Kessler Institute. Kessler Foundation's Center for Spinal Stimulation ... […]
via Bing News