NIAID-funded study could offset harsh effects of antibiotics.
Researchers at Memorial Sloan Kettering Cancer Center have shown that autologous fecal microbiota transplantation (auto-FMT) is a safe and effective way to help replenish beneficial gut bacteria in cancer patients who require intense antibiotics during allogenic hematopoietic stem cell transplantation. In their study, patients who underwent the procedure were randomly assigned into two groups: one group received standard care and the other received auto-FMT. The researchers found that auto-FMT resulted in the recovery of beneficial gut bacteria to near baseline levels within days, thus restoring patients’ digestive, immune and other essential functions. With standard care, beneficial bacteria typically take many weeks to recover from antibiotic treatment, leaving patients at risk of other infectious diseases, including Clostridium difficile.
The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, provided funding for part of the project. The study report appears in Science Translational Medicine.
“This important study suggests that clinical intervention using auto-FMT can safely reverse the disruptive effects of broad-spectrum antibiotic treatment,” says NIAID Director Anthony S. Fauci, M.D. “If validated in larger studies, this approach may prove to be a relatively simple way to quickly restore a person’s healthy microbiome following intensive antimicrobial therapy.”
Allogenic hematopoietic cell transplantation involves a donor — often but not exclusively a family member — who gives the recipient stem cells that re-establish bone marrow production of blood cells and immune function to combat cancer. Antibiotics are essential to prevent bacterial infections in stem cell recipients. However, antibiotics also destroy beneficial bacteria that enhance immune function and resistance to infection. The loss of beneficial bacteria increases the risk of certain life-threatening infectious diseases and graft-versus-host disease (GVHD).
The study involved cancer patients who provided their own fecal sample, which was frozen and stored prior to their cell transplantation procedure. Weeks later, when physicians confirmed that the transplanted cells were growing, they assessed the status of the patients’ beneficial gut bacteria. The first 25 patients who lacked known beneficial bacteria were enrolled into the study and randomly assigned to the different treatment groups: 14 received auto-FMT by enema and 11 received standard-of-care.
The patients who received auto-FMT consistently regained bacterial diversity, composition and function; recovery of beneficial bacteria in the 11 control patients was delayed.
The researchers are continuing to monitor the study patients to determine if auto-FMT improves patient outcomes, such as the incidence and severity of bacterial, viral and fungal infections and the incidence and severity of GVHD. Whether FMT from a healthy donor would be as beneficial as the patient’s own fecal sample at restoring beneficial bacteria remains to be studied.
The Latest on: Fecal microbiota transplantation
via Google News
The Latest on: Fecal microbiota transplantation
- FMT restores microbial diversity post-antibiotics in patients with cirrhosis on December 13, 2018 at 10:15 am
Fecal microbial transplant restored antibiotic-associated disruption in ... largely reversed by one dose of rectal FMT.” The FDA-monitored phase 1 safety trial included patients with decompensated cir... […]
- Fecal microbiome transplantation shows promise in treating colitis on December 5, 2018 at 4:15 am
There may, however, be a way to treat these symptoms and allow patients to continue cancer treatment. It’s called fecal microbiota transplantation (FMT). It involves transplanting gut bacteria from th... […]
- Fecal transplants help restore gut microbiome in cancer patients on September 27, 2018 at 5:29 pm
... before taking antibiotics (for fecal transplantation following the treatment) while the remaining 11 served as a control group undergoing regular standard of care. After the antibiotic interventio... […]
- Fecal microbiota transplantation helps restore beneficial bacteria in cancer patients on September 27, 2018 at 11:34 am
Researchers at Memorial Sloan Kettering Cancer Center have shown that autologous fecal microbiota transplantation (auto-FMT) is a safe and effective way to help replenish beneficial gut bacteria in ca... […]
- Fecal microbiota transplantation helps restore beneficial bacteria in cancer patients on September 26, 2018 at 2:14 pm
The Human Microbiome Project, launched by NIH in 2007, provided a glimpse of the microbial diversity of healthy humans and is exploring the possible relationship between human diseases and the microbi... […]
- Fecal microbiota transplantation produces sustained improvements in cognitive and clinical outcomes on April 13, 2018 at 11:04 pm
14 April 2018, Paris, France: A single treatment using an optimized, targeted form of faecal microbiota transplantation (FMT) produces sustained clinical and cognitive improvements, according to the r... […]
- Fecal Transplant Increasingly Seen As an Option to Treat a Nasty Superbug on March 13, 2018 at 7:38 am
The latest clinical practice guidelines for treating C-diff infection reflect this. "Fecal microbiota transplantation is recommended for patients with multiple recurrences of CDI who have failed appro... […]
via Bing News