Researchers from Eindhoven University of Technology (TU/e) and Keio University today present a practicable and reliable way to test for infectious diseases.
All you need are a special glowing paper strip, a drop of blood and a digital camera, as they write in the scientific journal Angewandte Chemie. Not only does this make the technology very cheap and fast – after twenty minutes it is clear whether there is an infection – it also makes expensive and time-consuming laboratory measurements in the hospital unnecessary. In addition, the test has a lot of potential in developing countries for the easy testing of tropical diseases.
The test shows the presence of infectious diseases by searching for certain antibodies in the blood that your body makes in response to, for example, viruses and bacteria. The development of handy tests for the detection of antibodies is in the spotlight as a practicable and quick alternative to expensive, time-consuming laboratory measurements in hospitals. Doctors are also increasingly using antibodies as medicines, for example in the case of cancer or rheumatism. So this simple test is also suitable for regularly monitoring the dose of such medicines to be able to take corrective measures in good time.
The use of the paper strip developed by the Dutch and Japanese researchers is a piece of cake. Apply a drop of blood to the appropriate place on the paper, wait twenty minutes and turn it over. “A biochemical reaction causes the underside of paper to emit blue-green light,” says Eindhoven University of Technology professor and research leader Maarten Merkx. “The bluer the color, the higher the concentration of antibodies.” A digital camera, for example from a mobile phone, is sufficient to determine the exact color and thus the result.
The color is created thanks to the secret ingredient of the paper strip: a so-called luminous sensor protein developed at TU/e. After a droplet of blood comes onto the paper, this protein triggers a reaction in which blue light is produced (known as bioluminescence). An enzyme that also illuminates fireflies and certain fish, for example, plays a role in this. In a second step, the blue light is converted into green light. But here comes the clue: if an antibody binds to the sensor protein, it blocks the second step. A lot of green means few antibodies and, vice versa, less green means more antibodies.
The ratio of blue and green light can be used to derive the concentration of antibodies. “So not only do you know whether the antibody is in the blood, but also how much,” says Merkx. By measuring the ratio precisely, they suffer less from problems that other biosensors often have, such as the signal becoming weaker over time. In their prototype, they successfully tested three antibodies simultaneously, for HIV, flu and dengue fever. Merkx expects the test to be commercially available within a few years.
The Latest on: Test for infectious diseases
via Google News
The Latest on: Test for infectious diseases
- First Light Diagnostics Commended by Frost & Sullivan for its MultiPath™ Platform for Infectious Disease Management on April 17, 2019 at 5:00 am
First Light's test has higher specificity than nucleic acid amplification tests, because it only detects disease-causing toxins that are ... The tests rapidly detect infections, identify infectious ... […]
- Infectious Disease Diagnostics Market Growth Rate, Trending Factors and Industry Size 2026 on April 17, 2019 at 2:37 am
These companies are taking efforts to develop and commercialize cost effective tools for the infectious disease diagnosis. Presently, the gold standard tests available for bacterial infections and ... […]
- Tests on Sick Workers at Mining Company in Guyana Rules Out Swine Flu But Finds Infectious Disease on April 16, 2019 at 10:04 am
Chief Medical Officer of the Ministry of Public Health, Dr Shamdeo Persaud (right) presented the findings of the investigation into the illness of GMI workers. GEORGETOWN, Guyana, Tuesday April 16, ... […]
- Pub customers tested for TB after drinker potentially spreads infectious disease on April 15, 2019 at 2:34 am
"TB is an infectious disease caused by bacteria ... “When a person is diagnosed, people who have been in close contact are offered screening tests to check if they are infected. "This is called ... […]
- How 2 Michigan kids tested positive for measles, but didn't have disease on April 12, 2019 at 5:03 pm
How 2 Michigan kids tested positive for measles, but didn't have disease Michigan health officials ... and people who've been immunized are not infectious after vaccination. Following the initial ... […]
- Person at West Valley charter school tests positive for tuberculosis on April 11, 2019 at 1:17 pm
County health officials were notified of the positive test late last week ... is a potentially serious infectious disease that mainly affects the lungs, according to Mayo Clinic. […]
- Latin America $811.5 Mn Cell Culture Market to 2025 - Increasing Incidence of Infectious Diseases Pressurizes Increasing Drug Discovery on April 10, 2019 at 3:29 pm
for the development of cells to test antibiotics against, and for research purposes that delve deep into the understanding of the effect of disease causing organisms within the human body ... […]
- Genetic Tests Are Fine for Ancestry, But Here Are 5 Things They Can’t Tell You on April 10, 2019 at 5:00 am
Getty Images Genetic tests taken at home have exploded in popularity in ... in the department of health policy and professor of medicine in the division of infectious diseases at Vanderbilt Medical ... […]
- Global Infectious Disease Testing Market to Achieve Beyond $24 Bn Mark by 2026 End on April 9, 2019 at 9:18 am
the rise in infectious diseases like HIV, hepatitis, tuberculosis, malaria, influenza, etc, rapid demand in the usage of molecular, biochemical techniques and diagnostic tests are factors promoting ... […]
via Bing News