Researchers from Charité – Universitätsmedizin Berlin and the Zuse Institute Berlin have developed a new generation of pain medications.
The researchers used computer simulations to develop new opioids that will only work at sites affected by injury or inflammation. These drugs can prevent the occurrence of brain- and gut-related side effects typically associated with conventional opioids and have been shown to be successful in preclinical studies. Results from this research have been published in Pain* and Scientific Reports**.
Opioids are a class of drugs with powerful pain-relieving properties. They are mainly used to treat the pain associated with tissue damage and inflammation, such as that caused by surgery or cancer. Common side effects associated with their use include drowsiness, nausea, constipation, dependency and, in some cases, respiratory arrest. The research team, which is led by Prof. Dr. Christoph Stein of the Department of Anesthesiology and Surgical Intensive Care Medicine on Campus Benjamin Franklin, are hoping to develop new types of pain medications which will work without producing dangerous side effects. Collaborating with PD Dr. Marcus Weber of the Zuse Institute Berlin, the researchers used computer simulations to develop two new opioids. In both cases, the researchers used fentanyl as the starting molecule.
The researchers hypothesized that tissues which are damaged or inflamed show stronger interaction between ‘opioid agonists’ – the substances that elicit the pain-relieving effect – and the opioid receptors they bind to. Their computer simulations suggested that this is due to an increased concentration of protons in inflamed tissues, which leads to lower pH values than in healthy tissues, resulting in acidic conditions. Opioid molecules need to undergo protonation before they can bind to and activate opioid receptors. The researchers used this knowledge to design two drugs that would only exist in their protonated state in the presence of inflammation. This restricts opioid receptor activation to sites of tissue damage or inflammation, rather than receptors in the brain or gut.
“Our innovative design method provides a robust basis for a new generation of pain medications,” reports Prof. Stein. He adds: “These drugs could help us both to avoid the dangerous side effects of conventional opioids and to reduce complications. They would also help us stem the opioid crisis, a problem that is particularly evident in the United States.”
The researchers hope to further develop these newly-designed drugs in order to make them available to patients. They also plan to enhance their understanding of the molecular processes underlying the complex interactions seen in inflamed tissues, in the hope that they may be able to support opioid optimization through the insights they gain. Ideally, their insights will also be beneficial for other drugs, such as those used to treat high blood pressure.
Receive an email update when we add a new PAIN MEDICATIONS article.
The Latest on: Pain medications
via Google News
The Latest on: Pain medications
- Chronic pain sufferers caught in crossfire of opioid war, struggling to get medication on November 12, 2018 at 3:18 pm
ST. LOUIS (KMOV.com) -- Some seniors and people in pain are struggling to get their medicine, They say there the unintended victims of the heroin epidemic. They’ve been on opiates, in some cases for d... […]
- COLD PAIN THERAPY MARKET on November 12, 2018 at 11:54 am
However, side-effects and discomfort associated with cold pain therapy treatment and substantial clinical evidences in favor of cold pain therapy may hamper the market growth. Though, stringent regula... […]
- Otitis Externa Treatment Market Analysis Demand, Research, Survey and Industry Forecast to 2024 on November 12, 2018 at 11:39 am
Otitis externa is characterized by pain, tenderness, redness ... Excessive moisture and trauma are the most common symptoms which should not avoided. The treatment for otitis extern is usually a local... […]
- Cannabinoids and Other Pain Relief Options on November 12, 2018 at 9:47 am
ENDV has an extremely promising non-invasive pain reduction treatment therapy called SofPulse that could be the answer for larger companies looking at opioid alternative pain relief solutions. […]
- Michelle Obama had IVF treatment — what is it and what does it cost? on November 12, 2018 at 8:57 am
“We sit in our own pain, thinking that somehow we’re broken ... The entire process, including the medications, freezing the eggs and other procedures, could cost between $15,000 and $20,000, depending ... […]
- Jaw Pain Relieved with TMJ Treatment in Miami Beach, FL by Drs. Howard… on November 12, 2018 at 6:28 am
Dental professionals, Dr. Howard Abrahams and Dr. Stan Frohlinger, are teaching patients suffering from jaw pain related to TMD in Miami Beach, FL, how their temporomandibular joint (TMJ) could be the ... […]
- Jaw Pain Relieved with TMJ Treatment in Miami Beach, FL by Drs. Howard Abrahams and Stan Frohlinger on November 12, 2018 at 5:15 am
MIAMI BEACH, Fla., Nov. 12, 2018 /PRNewswire-PRWeb/ -- Highly innovative prosthodontist Dr. Howard Abrahams and dentist Dr. Stan Frohlinger, are encouraging those across Miami Beach, FL, with TMD-rela... […]
- Muscle pain vs. joint pain – what’s the difference? on November 10, 2018 at 11:00 pm
in order to identify the type and source of the pain, and to construct a treatment plan. You should expect your physician to do a thorough physical examination, and if appropriate, some diagnostic ima... […]
- 'Only cannabis can ease my pain - so why must I buy from backstreet dealers?' on November 10, 2018 at 1:11 pm
Twice, an ambulance has been called after medication caused crippling stomach pain. “It’s like standing in front of a mountain,” she explains. “The pain starts at the bottom and gets worse with every ... […]
via Bing News