When the good and bad bacteria in our mouth become imbalanced, the bad bacteria form a biofilm (aka plaque), which can cause cavities, and if left untreated over time, can lead to cardiovascular and other inflammatory diseases like diabetes and bacterial pneumonia.
A team of researchers from the University of Illinois has recently devised a practical nanotechnology-based method for detecting and treating the harmful bacteria that cause plaque and lead to tooth decay and other detrimental conditions.
Oral plaque is invisible to the eye so dentists currently visualize it with disclosing agents, which they administer to patients in the form of a dissolvable tablet or brush-on swab. While useful in helping patients see the extent of their plaque, these methods are unable to identify the difference between good and bad bacteria.
“Presently in the clinic, detection of dental plaque is highly subjective and only depends on the dentist’s visual evaluation,” said Bioengineering Associate Professor Dipanjan Pan, head of the research team. “We have demonstrated for the first time that early detection of dental plaque in the clinic is possible using the regular intraoral X-ray machine which can seek out harmful bacteria populations.”
In order to accomplish this, Fatemeh Ostadhossein, a Bioengineering graduate student in Pan’s group, developed a plaque detection probe that works in conjunction with common X-ray technology and which is capable of finding specific harmful bacteria known as Streptococcus mutans (S. mutans) in a complex biofilm network. Additionally, they also demonstrated that by tweaking the chemical composition of the probe, it can be used to target and destroy the S. mutans bacteria.
The probe is comprised of nanoparticles made of hafnium oxide (HfO2), a non-toxic metal that is currently under clinical trial for internal use in humans. In their study, the team demonstrated the efficacy of the probe to identify biochemical markers present at the surface of the bacterial biofilm and simultaneously destroy S. mutans. They conducted their study on Sprague Dawley rats.
In practice, Pan envisions a dentist applying the probe on the patient’s teeth and using the X-ray machine to accurately visualize the extent of the biofilm plaque. If the plaque is deemed severe, then the dentist would follow up with the administering of the therapeutic HfO2 nanoparticles in the form of a dental paste.
In their study, the team compared the therapeutic ability of their nanoparticles with Chlorhexidine, a chemical currently used by dentists to eradicate biofilm. “Our HfO2nanoparticles are far more efficient at killing the bacteria and reducing the biofilm burden both in cell cultures of bacteria and in [infected] rats,” said Ostadhossein, noting that their new technology is also much safer than conventional treatment.
The nanoparticles’ therapeutic effect is due, said Pan, to their unique surface chemistry, which provides a latch and kill mechanism. “This mechanism sets our work apart from previously pursued nanoparticle-based approaches where the medicinal effect comes from anti-biotics encapsulated in the particles,” said Pan, also a faculty member of the Carle Illinois College of Medicine and the Beckman Institute for Advanced Science and Technology. “This is good because our approach avoids anti-biotic resistance issues and it’s safe and highly scalable, making it well-suited for eventual clinical translation.”
The Latest on: Oral plaque
via Google News
The Latest on: Oral plaque
- Ignoring Your Toothbrush and Floss Can Lead to Gingivitis and Even Worse Gum Issueson October 7, 2020 at 1:43 pm
Let's start from the beginning so you can clearly see how the oral-health dominoes fall. When bacteria in your mouth mixes with the food you're eating, Ziese says it produces an acidic slurry called ...
- Can-Fite Announces Positive Phase III Psoriasis Interim Data Analysison October 6, 2020 at 4:40 am
Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE:CFBI), a biotechnology company advancing a pipeline of proprietary small molecule drugs that address inflammatory, cancer and liver diseases, today ...
- Protect Your Teeth From Tartar Stains With This Dentist's Hygiene Tipson October 5, 2020 at 4:07 pm
Tartar is a porous "crusty blanket" that forms from plaque between your teeth and gum line and can easily trap stains and cause discoloration.
- Bad Breath and Canker Sores — Here's How Hormones Can Impact Your Oral Healthon October 5, 2020 at 1:47 pm
Due to hormonal fluctuations in a woman's life, they are more susceptible to oral health problems if they are not taking preventative care.
- Shoppers say this £24 water flosser cleans deep between teethon October 5, 2020 at 6:19 am
For those who dislike traditional flossing, water flossing might just be the answer. Enter the Fairywill Water Flosser which Amazon shoppers think is the best bang for your buck.
- What you should eat and avoid to maintain oral health explained by Dr Tanvir Singhon September 30, 2020 at 6:04 am
Our body is a complex machine, and the food we eat has a direct impact on our health. It is essential that you eat the right kind of foods to ...
- BURST Oral Care Launches New Oral Probioticson September 28, 2020 at 6:10 am
BURST Oral Care has released the latest in its line-up of high quality products, Oral Probiotics. As the first oral care company to ...
- Oclean Launches the World’s Smallest Smart Oral Irrigatoron September 25, 2020 at 12:00 am
Small Yet Mighty. Smallest water flosser on the market, which means floss is not the only portable choice to clean your teeth, users can also enjo ...
- Frank A. Scannapiecoon September 24, 2020 at 5:00 pm
Frank A. Scannapieco is a periodontist and microbiologist. He can speak to the media about dental plaque and the connection between oral and overall health, particularly in at-risk populations. His ...
via Bing News