A team of Brigham and Women’s Hospital researchers have developed a way to bioprint tubular structures that better mimic native vessels and ducts in the body.
The 3-D bioprinting technique allows fine-tuning of the printed tissues’ properties, such as number of layers and ability to transport nutrients. These more complex tissues offer potentially viable replacements for damaged tissue. The team describes its new approach and results in a paper published on Aug. 23 in Advanced Materials.
“The vessels in the body are not uniform,” said Yu Shrike Zhang, PhD, senior author on the study and an associate bioengineer in BWH’s Department of Medicine. “This bioprinting method generates complex tubular structures that mimic those in the human system with higher fidelity than previous techniques.”
Many disorders damage tubular tissues: arteritis, atherosclerosis and thrombosis damage blood vessels, while urothelial tissue can suffer inflammatory lesions and deleterious congenital anomalies.
To make the 3D bioprinter’s “ink,” the researchers mixed the human cells with a hydrogel, a flexible structure composed of hydrophilic polymers. They optimized the chemistry of the hydrogel to allow the human cells to proliferate, or “seed,” throughout the mixture.
Next, they filled the cartridge of a 3D bioprinter with this bio-ink. They fitted the bioprinter with a custom nozzle that would allow them to continuously print tubular structures with up to three layers. Once the tubes were printed, the researchers demonstrated their ability to transport nutrients by perfusing fluids.
The researchers found that they could print tissues mimicking both vascular tissue and urothelial tissue. They mixed human urothelial and bladder smooth muscle cells with the hydrogel to form the urothelial tissue. To print the vascular tissue, they used a mixture of human endothelial cells, smooth muscle cells and the hydrogel.
The printed tubes had varying sizes, thicknesses and properties. According to Zhang, structural complexity of bioprinted tissue is critical to its viability as a replacement for native tissue. That’s because natural tissues are complex. For instance, blood vessels are comprised of multiple layers, which in turn are made up of various cell types.
The team plans to continue preclinical studies to optimize the bio-ink composition and 3D-printing parameters before testing for safety and effectiveness.
“We’re currently optimizing the parameters and biomaterial even further,” said Zhang. “Our goal is to create tubular structures with enough mechanical stability to sustain themselves in the body.”
The Latest on: 3-D bioprinting
via Google News
The Latest on: 3-D bioprinting
- 3D Bioprinting Market - Services is expected to continue demand for services in years to come till 2025 on September 16, 2018 at 1:19 am
3D Bioprinting is defined as a three-dimensional printing of biological tissues and organs with the help of living cells. It is basically done through organ transplantation and tissue engineering. It ... […]
- 3D Bioprinting: Comparing Lattice Scaffolds with Traditional Rectangular Sheets on September 13, 2018 at 1:49 pm
Bioprinting is not a simple endeavor – if it were, we would likely be transplanting 3D printed organs by now. It’s a delicate process that requires a number of factors to be in place ... […]
- PetriPrinter: Open Source Software Designed Specifically for Bioprinting on September 13, 2018 at 10:07 am
Bioprinting is a growing, exciting field, with advancements being made toward the treatment of diseases and the eventual 3D printing of organs. Bioprinters are becoming more sophisticated and ... […]
- Brigham and Women’s Hospital successfully 3D bioprints blood vessels on August 30, 2018 at 3:47 am
According to BWH’s report, the 3D bioprinting technique allows for better replications of the tissues’ properties, such as the number of layers and ability to transport nutrients. These ... […]
- Researchers 3D bioprint tubular structures that mimic vessels and ducts on August 27, 2018 at 6:38 am
"This bioprinting method generates complex tubular structures that mimic those in the human system with higher fidelity than previous techniques." To make the 3-D bioprinter's "ink," the researchers m... […]
- “3D Bioprinting for Life Science R&D Market” on August 27, 2018 at 1:03 am
WiseGuyReports.Com Publish a New Market Research Report On “ 3D Bioprinting for Life Science R&D 2018 Global Market Outlook,Research,Trends and Forecast to 2025”. This report focuses on the global 3D ... […]
- One step closer to bioengineered replacements for vessels and ducts on August 24, 2018 at 5:00 am
The 3-D bioprinting technique allows fine-tuning of the printed tissues' properties, such as number of layers and ability to transport nutrients. These more complex tissues offer potentially ... […]
- 3D Bioprinting Market Forecasts Rapid Growth, Forecast 2017 - 2025 on August 22, 2018 at 9:07 am
Bioprinting is the 3D printing of various biocompatible materials, including cells and components, into three dimensional functional living tissues. 3D bioprinting is relatively an emerging domain but ... […]
- Bioprinting bone substitute materials with cell-laden bioinks on August 21, 2018 at 7:07 am
Explore further: 3-D printed biomaterials for bone tissue engineering More information: Tilman Ahlfeld et al. Bioprinting of mineralized constructs utilizing multichannel plotting of a self-setting ca... […]
via Bing News