With the support of the National Institute on Drug Abuse, scientists at Wake Forest School of Medicine have been working to find a safe, non-addictive pain killer to help fight the current opioid crisis in this country.
And they may have done just that, though in an animal model.
Known as AT-121, the new chemical compound has dual therapeutic action that suppressed the addictive effects of opioids and produced morphine-like analgesic effects in non-human primates.
“In our study, we found AT-121 to be safe and non-addictive, as well as an effective pain medication,” said Mei-Chuan Ko, Ph.D., professor of physiology and pharmacology at the School of Medicine, part of Wake Forest Baptist Medical Center.
“In addition, this compound also was effective at blocking abuse potential of prescription opioids, much like buprenorphine does for heroin, so we hope it could be used to treat pain and opioid abuse.”
The findings are published in the Aug. 29 issue of the journal Science Translational Medicine.
The main objective of this study was to design and test a chemical compound that would work on both the mu opioid receptor, the main component in the most effective prescription pain killers, and the nociceptin receptor, which opposes or blocks the abuse and dependence-related side effects of mu-targeted opioids. Current opioid pain drugs, such as fentanyl and oxycodone, work only on the mu opioid receptor, which also produces unwanted side effects – respiratory depression, abuse potential, increased sensitivity to pain and physical dependence.
“We developed AT-121 that combines both activities in an appropriate balance in one single molecule, which we think is a better pharmaceutical strategy than to have two drugs to be used in combination,” Ko said.
In the study, the researchers observed that AT-121 showed the same level of pain relief as an opioid, but at a 100-times lower dose than morphine. At that dose, it also blunted the addictive effects of oxycodone, a commonly abused prescription drug.
The bifunctional profile of AT-121 not only gave effective pain relief without abuse potential, it also lacked other opioid side-effects that patients typically struggle with, such as itch, respiratory depression, tolerance and dependence.
“Our data shows that targeting the nociceptin opioid receptor not only dialed down the addictive and other side-effects, it provided effective pain relief,” Ko said. “The fact that this data was in nonhuman primates, a closely related species to humans, was also significant because it showed that compounds, such as AT-121, have the translational potential to be a viable opioid alternative or replacement for prescription opioids.”
Next steps include conducting additional preclinical studies to collect more safety data, and then if all goes well, applying to the Food and Drug Administration for approval to begin clinical trials in people, Ko said.
Receive an email update when we add a new NON-ADDICTIVE PAIN KILLER article.
The Latest on: Non-addictive pain killer
via Google News
The Latest on: Non-addictive pain killer
- Seed Coating Materials Market | Key Players are Clariant International, Chemtura Corporation, BASF SE, Bayer CropScience AG on September 21, 2018 at 11:30 pm
Seed coating is the method of applying seed protection formulation over seed surface. The prime aim for seed coating is enhance protection of the seeds against pathogenic, fungal attacks. Applying wei... […]
- Frost & Sullivan: Suppliers of Sustainable Water-based Decorative Coatings Gain Ground on Solvent-based Paint Suppliers on September 21, 2018 at 12:34 am
Partnerships with raw material manufacturers will further help them formulate innovative coating products that can lower energy, labor, and overall coating system costs for customers. "The use of ... […]
- Coating additives market forecasts from 2017 to 2026 scrutinized in new research on September 20, 2018 at 7:34 am
Higher quality of additives with complex technological specifications in terms of finish, rheology, material constituents. has been the primary indicators for success. Coating Additives Market partici... […]
- Seed Coating Materials Market Scope, Size, Share, Sales, Revenue Analysis Techniques, Top Key Players Review and Fast Forward Research on September 20, 2018 at 4:47 am
Seed Coating Materials Market Global Research Report by Type (Polymers, Colorants, Binders), Crop Type (Fruits & Vegetables, Cereals & Grains, Pulses & Oilseeds) and Region (North America, Europe, Asi... […]
- 2018 Advancements in Artificial Intelligence, Fire-resistant Coatings, Water Desalination, and Fuel Cells - ResearchAndMarkets.com on September 19, 2018 at 10:15 am
materials, coatings, renewable fuels, automotive, power systems, sustainable energy solutions and innovations that contribute to a cleaner and greener environment. Key Topics Covered For more informat... […]
- Global industrial coatings market forecasts 2018-2022 detailed in new research report on September 19, 2018 at 5:10 am
The industrial coatings market is expected to increase due to growing demand from automotive, increasing urban population, growing infrastructural investment. Yet the market faces some challenges such ... […]
- Using Graphene Technology in the Coatings Industry on September 19, 2018 at 3:18 am
Graphene can always bring mechanical reinforcement as a premium to coatings, thanks to its unique crystal structure. Graphene-reinforced materials have huge potential for automotive and aerospace appl... […]
- Thermal Spray Coatings Materials Market Trends by 2025: Top Players Like Praxair Surface Technologies, Oerlikon Group, Bodycoteplc, H.C. Starck GmbH on September 14, 2018 at 7:39 am
New York, NY -- (SBWIRE) -- 09/14/2018 -- Top key vendors in Thermal Spray Coatings Materials Market include are Praxair Surface Technologies, Oerlikon Group, Bodycoteplc, H.C. Starck GmbH, Cincinnati ... […]
- Powder Coatings Market Report Provides Growth, Share, Demand and Study of Key Players, 2018-2022: Radiant Insights, Inc. on September 13, 2018 at 5:10 am
Powder coatings are a powder material that comprises pigmented thermoplastic particles. Electrostatically the powder is sprayed on constituents and then bonded into an unchanging and strong coating. […]
via Bing News