A natural human enzyme can biodegrade graphene, scientists from the Graphene Flagship have announced.
Degradation of pristine graphene occurs in the human body when interacting with a naturally occurring enzyme found in the lung, announced Graphene Flagship partners; the French National Centre for Scientific Research (CNRS), University of Strasbourg, Karolinska Institute and University of Castilla–La Mancha (UCLM).
Graphene based products are being designed to be interfaced with the human body within the Graphene Flagship, including flexible biomedical electronic devices. If graphene is to be used for such biomedical applications, it should be biodegradable and thus be expelled from the body.
To test how graphene behaves within the body, Alberto Bianco and his team at Graphene Flagship partner CNRS, conducted several tests looking at if and how graphene was broken down with the addition of a common human enzyme. The enzyme in question, myeloperoxidase (MPO), is a peroxide enzyme released by neutrophils, cells that are responsible for the elimination of any foreign bodies or bacteria that enter the body, found in the lungs. If a foreign body or bacteria is detected inside of the body, neutrophils surround it and secrete MPO, thereby destroying the threat. Previous work by Graphene Flagship partners found MPO to successfully biodegrade graphene oxide [Small, 20151; Nanoscale, 20182]. However the structure of non-functionalized graphene was thought to be more degradation resistant. To test this, Bianco and his team looked at the effects of MPO, ex vivo, on two graphene forms; single- and few-layer.
Bianco explains, “We used two forms of graphene, single- and few-layer, prepared by two different methods in water. They were then taken and put in contact with myeloperoxidase in the presence of hydrogen peroxide. This peroxidase was able to degrade and oxidise them. This was not really expected because we thought that non functionalized graphene was more resistant than graphene oxide.”
Rajendra Kurapati, first author on the study, from Graphene Flagship partner CNRS, said, “The results emphasize that highly dispersible graphene could be degraded in the body by the action of neutrophils. This would open the new avenue for developing graphene-based materials.”
With successful ex-vivo testing, in-vivo testing is the next stage. Bengt Fadeel, Professor at Graphene Flagship partner Karolinska Institute, “Understanding whether graphene is biodegradable or not is important for biomedical and other applications of this material. The fact that cells of the immune system are capable of handling graphene is very promising.”
Prof. Maurizio Prato, leader of Work Package 4, dealing with Health and Environment impact studies, based at Graphene Flagship Partner University of Trieste, said, “The enzymatic degradation of graphene is a very important topic, because in principle, graphene dispersed in the atmosphere could produce some harm. Instead, if there are microorganisms able to degrade graphene and related materials, the persistence of these materials in our environment will be strongly decreased. These types of studies are needed. What is also needed is to investigate the nature of degradation products. Once graphene is digested by enzymes, it could produce harmful derivatives. We need to know the structure of these derivatives and study their impact on health and environment.”
Learn more: Biodegradable Graphene
The Latest on: Graphene
via Google News
The Latest on: Graphene
- Try graphene, a new clothing material that can keep you cool on January 3, 2019 at 7:38 am
The textile industry is now evolving from traditional cotton and silk to new materials — graphene, for instance. The space is seeing start-ups and established textile houses, alike, jumping on the ban... […]
- Could graphene see metal-air batteries rise to the top? on January 3, 2019 at 7:38 am
Could graphene see metal-air batteries rise to the top? Indian startup Log 9 Materials seems to think so – the firm, which is a spin-off from the Indian Institute of Technology Roorkee, suggests the w... […]
- Today's Research Reports on BlackBerry, Real Matters, Graphene 3D Lab and BSM Technologies on January 3, 2019 at 4:58 am
NEW YORK, NY / ACCESSWIRE / January 3, 2019 / The Market Edge strives to provide investors with free daily equity research reports analyzing major market events. Take a few minutes to register ... […]
- Global Graphene Nanomesh Market 2018 Analysis and Forecast to 2025 on January 2, 2019 at 11:36 pm
MarketResearchNest.com adds “Global Graphene Nanomesh Market Research Report 2018”new report to its research database. The report spread across 116 pages with multiple tables and figures in it. This c... […]
- Vittoria Qurano 46 Disc Graphene-infused racing disc wheels review on January 2, 2019 at 4:26 pm
Vittoria’s star has been rising over recent years. This has been mostly down to its technical advancements in tyres, fusing graphene into the compound to improve the natural elasticity of the rubber f... […]
- Boffins manage to keep graphene qubits 'quantum coherent' for all of 55... nanoseconds on January 2, 2019 at 9:55 am
What happens when a Royal Navy warship sees a NATO task force headed straight for it? A crash course in Morse Physicists have formed qubits – quantum bits – from graphene atoms for the first time, acc... […]
- Researchers Create Smart Composite Material from Graphene Oxide and Seaweed-Derived Alginate on January 2, 2019 at 9:39 am
Usually when I think about seaweed, I’m trying to decide which particular sushi roll to order at dinner. But a team of researchers from Brown University in Rhode Island, which is well-versed in ... […]
- Graphene-based implant overcomes technical limitation to record brain activity at extremely low frequencies on January 2, 2019 at 4:33 am
(Nanowerk News) The body of knowledge about the human brain is growing exponentially, but questions big and small remain unanswered. Researchers have been using electrode arrays to record the brain’s ... […]
- The Global Graphene Expo: Women in Materials Research on January 2, 2019 at 12:56 am
The National Graphene Agency (NGA) is the primary U.S. based organisation publicly promoting the commercialization of graphene. Despite only running for two years, is has already had a significant imp... […]
- Physicists measure how long graphene qubits hover in "alive/dead" superposition on January 1, 2019 at 10:29 pm
Researchers have managed to record how long graphene "qubits" can stay in a superposition state(Credit: depositPlot/Depositphotos) Practical quantum computers may be another step closer to reality ... […]
via Bing News