NIH Scientists See Therapeutic Potential Against Bacteria, Viruses
National Institutes of Health researchers have identified a naturally occurring lipid—a waxy, fatty acid—used by a disease-causing bacterium to impair the host immune response and increase the chance of infection. Inadvertently, they also may have found a potent inflammation therapy against bacterial and viral diseases.
Lipids are known to help Francisella tularensis bacteria, the cause of tularemia, to suppress host inflammation when infecting mouse and human cells. In a new study published in the Journal of Innate Immunity, researchers from NIH’s National Institute of Allergy and Infectious Diseases found a form of the lipid phosphatidylethanoloamine, or PE, present in the bacterium. The composition of PE found in F. tularensis differs from PE found in other bacteria. In cell-culture experiments, the researchers discovered that the natural and a synthetic form of PE reduced inflammation caused by both tularemia bacteria and dengue fever virus.
Tularemia is a life-threatening disease spread to humans via contact with an infected animal or through the bite of a mosquito, tick or deer fly. Although tularemia can be successfully treated with antibiotics, it is difficult to diagnose, mainly because F. tularensis bacteria can suppress the human immune response. Dengue fever, primarily spread by Aedes aegypti mosquitoes, is rarely fatal but usually leads to a high fever, severe headache and pain throughout the body. There is no specific treatment for dengue fever.
After identifying PE as the lipid that impaired the immune response, the scientists began to consider its potential therapeutic value. Because natural F. tularensis is highly infectious and therefore challenging to work with, the group developed synthetic lipids—PE2410 and PEPC2410—that would be much easier to study and produce. They then verified that both synthetic lipids also suppressed the immune response during infection of mouse and human cells in the laboratory.
Because several types of viral infections involve an unconstrained inflammatory response, the group tested natural and their synthetic PE in the laboratory against dengue fever virus-infected human cells. Both versions inhibited the immune response compared to the immune response seen in infected but untreated cells.
The group plans to continue exploring how F. tularensis impairs the immune response. They hope their findings will eventually lead to the development of a potent, broad-spectrum anti-inflammatory therapeutic.
Learn more: Natural Lipid Acts as Potent Anti-Inflammatory
The Latest on: Inflammation therapy
via Google News
The Latest on: Inflammation therapy
- How occupational therapy can help people with arthritis on April 17, 2019 at 6:13 am
Occupational therapy may sound like something exclusive to people who ... that a recent study suggested as many as 91 million might be dealing with this painful inflammation and stiffness of the ... […]
- This gene could reduce inflammation after stroke on April 17, 2019 at 4:06 am
It is unlikely that gene therapy delivered by viruses will become the go-to ... Jung further added that not all inflammation in the brain is bad as it plays a role in fighting infection and helps ... […]
- Mesoblast poised to file cell therapy for GVHD in US on April 17, 2019 at 3:22 am
Steroids are the first-line therapy, but in around 15% of cases can’t resolve the acute inflammatory response. In those cases, the death rate can be as high as 70% after 100 days, but in ... […]
- Experts Warn Arthritis Sufferers About the Dangers of Gold Therapy on April 16, 2019 at 2:53 am
There were arthritis sufferers who stated that gold therapy helped reduce inflammation, but administering it could be quite painful. The Cochrane Database of Systemic Reviews published a review ... […]
- Gene that can reduce inflammation after stroke decoded on April 15, 2019 at 9:47 pm
It is unlikely that gene therapy delivered by viruses will become ... Jung further added that not all inflammation in the brain is bad as it plays a role in fighting infection and helps clear ... […]
- Statin exposure associated with idiopathic inflammatory myositis on April 15, 2019 at 6:39 am
Clinical question: What is the association between exposure to statin medications and histologically confirmed idiopathic inflammatory myositis? Background: More than 200 million people worldwide use ... […]
- Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling on April 15, 2019 at 2:15 am
Ischemic cerebral stroke is a major cause of death and morbidity. Currently, no neuroprotective agents have been shown to impact the clinical outcomes in cerebral stroke cases. Here, we report ... […]
- A molecular biomarker for prediction of clinical outcome in children with ASD, constipation, and intestinal inflammation on April 12, 2019 at 2:18 am
In the first group, fast responding chronic constipation, patients experienced resolution of their presenting symptoms including constipation and, with ongoing anti-inflammatory (maintenance) therapy ... […]
- Biotech startup using gene therapy to treat pets raises $20M on April 10, 2019 at 8:02 am
The company plans to use the proceeds to advance its pipeline of one-time gene therapy therapeutics for major chronic pet health conditions including kidney disease, pain and inflammatory skin ... […]
via Bing News