Experiments in fruit flies show increased lifespan thanks to a combination of probiotics and an herbal supplement
You are what you eat. Or so the saying goes. Science now tells us that we are what the bacteria living in our intestinal tract eat and this could have an influence on how well we age. Building on this, McGill University scientists fed fruit flies with a combination of probiotics and an herbal supplement called Triphala that was able to prolong the flies’ longevity by 60 % and protect them against chronic diseases associated with aging.
The study, published in Scientific Reports, adds to a growing body of evidence of the influence that gut bacteria can have on health. The researchers incorporated a symbiotic – made of probiotics with a polyphenol-rich supplement – into the diet of fruit flies.
The flies fed with the synbiotic lived up to 66 days old – 26 days more than the ones without the supplement. They also showed reduced traits of aging, such as mounting insulin resistance, inflammation and oxidative stress.
“Probiotics dramatically change the architecture of the gut microbiota, not only in its composition but also in respect to how the foods that we eat are metabolized,” says Satya Prakash, professor of biomedical engineering in McGill’s Faculty of Medicine and senior author of the study. “This allows a single probiotic formulation to simultaneously act on several biochemical signaling pathways to elicit broad beneficial physiological effects, and explains why the single formulation we present in this paper has such a dramatic effect on so many different markers”.
The fruit fly is remarkably similar to mammals with about 70 % similarity in terms of their biochemical pathways, making it a good indicator of what would happen in humans, adds Prakash.
“The effects in humans would likely not be as dramatic, but our results definitely suggest that a diet specifically incorporating Triphala along with these probiotics will promote a long and healthy life.”
The authors also say that the findings can be explained by the “gut-brain axis,” a bidirectional communication system between microorganisms residing in the gastrointestinal tract – the microbiota – and the brain. In the past few years, studies have shown the gut-brain axis to be involved in neuropathological changes and a variety of conditions such as irritable bowel syndrome, neurodegeneration and even depression. Few studies, however, have successfully designed gut microbiota-modulating therapeutics having effects as potent or broad as the formulation presented in the new study.
Learning from traditional medicine
The herbal supplement used in the study, Triphala, is a formulation made from amalaki, bibhitaki and haritaki, fruits used as medicinal plants in Ayurveda, a form of traditional Indian medicine.
Susan Westfall, a former PhD student at McGill and lead author of the study, says the idea of combining Triphala and probiotics comes from her long-standing interest in studying natural products derived from traditional Indian medicine and their impact on neurodegenerative diseases.
“At the onset of this study, we were hopeful that combining Triphala with probiotics would be at least a little better than their individual components in terms of physiological benefit, but we did not imagine how successful this formulation would be,” says Westfall, who is now a postdoctoral fellow at the Icahn School of Medicine at Mount Sinai in New York, USA.
The new study, which includes data filed in a US provisional patent through a company cofounded by the authors, has the potential to impact the field of the microbiome, probiotics and human health.
Considering the broad physiological effects of this formulation shown in the fruit fly, Prakash hopes their formulation could have interesting applications in a number of human disorders such as diabetes, obesity, neurodegeneration, chronic inflammation, depression, irritable bowel syndrome and even cancer.
The Latest on: Longevity
via Google News
The Latest on: Longevity
- Betty White's Emmys Speech Proved Humor Is the Secret to Longevity on September 18, 2018 at 9:28 am
Twitter was going wild on Monday night when Betty White, 96, radiantly graced the stage of the 2018 Emmy Awards. The Golden Girls star was being honored for spending more than 80 years in the limeligh... […]
- Fasting For Longevity on September 17, 2018 at 2:23 pm
Intermittent fasting has been linked to lower risks of heart disease, cancer, diabetes, and aging according to a study from the National Institute on Aging. Researchers from NIA have found increasing ... […]
- Longevity and Legacy: Portfolio Strategies for Older Clients on September 17, 2018 at 12:26 pm
Client conversations on the subject of longevity and aging can sometimes be sensitive and challenging -- especially for advisors with clients who are nearing the end of their working years. How do you ... […]
- An ode to Daniel Nestor and his longevity on September 17, 2018 at 3:27 am
After a career spanning 28 years, one of the greatest doubles players of all-time - Daniel Nestor officially called it quits after notching up an astonishing 1062 doubles wins. Nestor was the epitome ... […]
- Longevity study gives trophy to tennis on September 14, 2018 at 5:52 pm
Horse racing is the sport of kings. Baseball, the American pastime. Boxing, the sweet science. Soccer, the beautiful game. Tennis, we now learn, is the sport of long life. I started playing tennis whe... […]
- Hyde: John Denney's 209-game lesson in longevity, hard work and, yes, luck | Commentary on September 13, 2018 at 3:45 pm
Before becoming an actor, Harrison Ford was a cabinet installer who one day took a job at film director George Lucas’s home. That changed his life. Oprah Winfrey, at 17, said she aspired to be a broad... […]
- AnAge database of animal longevity and other aging databases on September 12, 2018 at 11:39 pm
The DrugAge database contains an extensive compilation of drugs, compounds and supplements (including natural products and nutraceuticals) with anti-aging properties that extend longevity in model org... […]
- Secret Fork: Gregg's has found a longevity formula in menu, portions, freshly cut meat on September 12, 2018 at 11:04 am
Secret Fork: Gregg's has found a longevity formula in menu, portions, freshly cut meat Gregg's Substation started out downtown in 1976, but it now resides at 41st and Prairie. Check out this story on ... […]
- Full-fat dairy may boost longevity and health on September 12, 2018 at 7:47 am
Public Domain MaxPixel -- Go ahead and dig in! It's healthier than you think. A large global study has found that people who consume full-fat dairy have lower rates of cardiovascular disease and morta... […]
via Bing News