A penetrating injury from shrapnel is a serious obstacle in overcoming battlefield wounds that can ultimately lead to death.Given the high mortality rates due to hemorrhaging, there is an unmet need to quickly self-administer materials that prevent fatality due to excessive blood loss.
With a gelling agent commonly used in preparing pastries, researchers from the Inspired Nanomaterials and Tissue Engineering Laboratory have successfully fabricated an injectable bandage to stop bleeding and promote wound healing.
In a recent article “Nanoengineered Injectable Hydrogels for Wound Healing Application” published in Acta Biomaterialia, Dr. Akhilesh K. Gaharwar, assistant professor in the Department of Biomedical Engineering at Texas A&M University, uses kappa-carrageenan and nanosilicates to form injectable hydrogels to promote hemostasis (the process to stop bleeding) and facilitate wound healing via a controlled release of therapeutics.
“Injectable hydrogels are promising materials for achieving hemostasis in case of internal injuries and bleeding, as these biomaterials can be introduced into a wound site using minimally invasive approaches,” said Gaharwar. “An ideal injectable bandage should solidify after injection in the wound area and promote a natural clotting cascade. In addition, the injectable bandage should initiate wound healing response after achieving hemostasis.”
The study uses a commonly used thickening agent known as kappa-carrageenan, obtained from seaweed, to design injectable hydrogels. Hydrogels are a 3-D water swollen polymer network, similar to Jell-O, simulating the structure of human tissues.
When kappa-carrageenan is mixed with clay-based nanoparticles, injectable gelatin is obtained. The charged characteristics of clay-based nanoparticles provide hemostatic ability to the hydrogels. Specifically, plasma protein and platelets form blood adsorption on the gel surface and trigger a blood clotting cascade.
“Interestingly, we also found that these injectable bandages can show a prolonged release of therapeutics that can be used to heal the wound” said Giriraj Lokhande, a graduate student in Gaharwar’s lab and first author of the paper. “The negative surface charge of nanoparticles enabled electrostatic interactions with therapeutics thus resulting in the slow release of therapeutics.”
The Latest on: Injectable hydrogels
via Google News
The Latest on: Injectable hydrogels
Carrageenan Market Trend 2018-2027: Key Findings, Regional Analysis, Top Key Players Review, Future Prospects and Industry Research Report
on April 18, 2018 at 9:27 am
April 2018 Researchers used kappa-carrageenan and nanosilicates to form injectable hydrogels to promote hemostasis (the process to stop bleeding) and facilitate wound healing via a controlled release of therapeutics. March 2018 The National Organic ... […]
Injectable Bandage Stops Bleeding and Promotes Healing
on April 17, 2018 at 10:51 am
An injectable hydrogel based on kappa-carrageenan (κCA), a natural polysaccharide commonly used as a thickening agent for pastries, can facilitate wound healing, claims a new study. Developed by researchers at Texas A&M University (TAMU; College Station ... […]
Experimental injectable bandage could slow down bleeding
on April 16, 2018 at 11:28 am
The hydrogel, which they have specifically proposed as a solution ... In 2014, another medical technology company, RevMedX, developed an experimental version of an injectable bandage branded XStat, a syringe that creates a sealed barrier made up of tiny ... […]
New self-assembling protein hydrogels may hold many applications for biomedicine
on April 16, 2018 at 7:12 am
"Ours are the first protein hydrogels with designed mechanical integrity to be able to specifically encapsulate drugs—getting them closer to use in biomedical applications," Montclare says. Because they are soft gels, they are potentially injectable and ... […]
Augmenix, Inc. Announces SpaceOAR® Hydrogel is Now Available to Millions More Americans
on April 13, 2018 at 10:28 am
pain or discomfort associated with SpaceOAR hydrogel; needle penetration or injection of SpaceOAR hydrogel into the bladder, prostate, rectal wall, rectum or urethra; local inflammatory reactions; infection; injection of air, fluid or SpaceOAR hydrogel ... […]
Hydrogel could totally change treatment of diabetic wounds
on April 12, 2018 at 2:43 pm
A hydrogel that can help the body heal may also be particularly good at treating wounds related to diabetes, new research suggests. Tests on diabetic animal models show that the injectable hydrogel significantly accelerates wound healing compared with ... […]
Injectable Hydrogel Bandage Could Save Lives on the Battlefield
on April 11, 2018 at 12:58 am
A team from the Inspired Nanomaterials and Tissue Engineering Laboratory at Texas A&M University have developed an injectable, hydrogel bandage that can stop the bleeding from deep injuries, such as those suffered by soldiers on the battlefield, and ... […]
Drug delivery gel can heal without the drugs
on April 7, 2018 at 9:34 am
During development, the researchers often tested the hydrogels by infusing them with bioactive small molecules, cells, or proteins before injection. The researchers report in the journal Biomaterials that a particular hydrogel, a self-assembling ... […]
Hydrogel delivery enables long-lasting, ‘flare-responsive’ arthritis treatment
on April 6, 2018 at 6:05 am
In mice, they observed that a single dose of TA-loaded hydrogel decreased arthritis activity in the injected paw, while an identical dose injected normally did not. The findings appear in Nature Communications. RELATED: Could an injection replace surgery ... […]
via Bing News