A KAIST team presented a highly customizable neural stimulation method. The research team developed a technology that can print the heat pattern on a micron scale to enable the control of biological activities remotely.
The researchers integrated a precision inkjet printing technology with bio-functional thermo-plasmonic nanoparticles to achieve a ‘selective nano-photothermal neural stimulation method.’
The research team of Professor Yoonkey Nam at the Department of Bio and Brain Engineering expects this will serve as an enabling technology for personalized precision neuromodulation therapy for patients with neurological disorders.
The nano-photothermal neural stimulation method uses the thermo-plasmonic effect of metal nanoparticles to modulate the activities of neuronal networks. With the thermo-plasmonic effect, metal nanoparticles can absorb specific wavelength of illuminated light to efficiently generate localized heat. The research team discovered the inhibitory behavior of spontaneous activities of neurons upon photothermal stimulation four years ago. Since then, they have developed this technology to control hyperactive behaviors of neurons and neural circuits, which is often found in neurological disorders such as epilepsy.
In order to overcome the limitation on the spatial selectivity and resolution of the previously developed nano-photothermal method, the team adopted an inkjet printing technology to micro pattern the plasmonic nanoparticles (a few tens of microns), and successfully demonstrated that the nano-photothermal stimulation can be selectively applied according to the printed patterns.
The researchers applied a polyelectrolyte layer-by-layer coating method to printing substrates in a way to improve the pattern fidelity and achieve the uniform assembly of nanoparticles. The electrostatic attraction between the printed nanoparticles and the coated printing substrate also helped the stability of the attached nanoparticles. Because the polyelectrolyte coating is biocompatible, biological experiments including cell culture are possible with the technology developed in this work.
Using printed gold nanorod particles in a few tens of microns resolution over a several centimeters area, the researchers showed that highly complex heat patterns can be precisely formed upon light illumination according to the printing image.
Lastly, the team confirmed that the printed heat patterns can selectively and instantaneously inhibit the activities of cultured hippocampal neurons upon near-infrared light illumination. Because the printing process is applicable to thin and flexible substrates, the technology can be easily applied to implantable neurological disorder treatment devices and wearable devices. By selectively applying the heat patterns to only the desired cellular areas, customized and personalized photothermal neuromodulation therapy can be applied to patients.
“The fact that any desired heat patterns can be simply ‘printed’ anywhere broadens the applicability of this technology in many engineering fields. In bioengineering, it can be applied to neural interfaces using light and heat to modulate physiological functions. As another engineering application, for example, printed heat patterns can be used as a new concept of anti-counterfeit applications,” said the principal investigator, Yoonkey Nam at KAIST.
The Latest on: Nano-photothermal neural stimulation
via Google News
The Latest on: Nano-photothermal neural stimulation
- Here’s an update from ‘Jeopardy!’ host Alex Trebek, who has been busy since his diagnosis on April 17, 2019 at 4:06 pm
CINCINNATI, OH (FOX19) - Since the March announcement of his stage 4 pancreatic cancer diagnosis, long-time “Jeopardy!” host Alex Trebek has stayed busy. He recently finished taping shows for Season ... […]
- ‘Jeopardy’ host Alex Trebek plans to return in September, despite cancer diagnosis on April 17, 2019 at 3:58 pm
“Jeopardy” is readying for its summer break, but longtime host Alex Trebek, who is battling pancreatic cancer, said he looks forward to returning to the popular TV game show September. “I look forward ... […]
- Jeopardy! Host Alex Trebek Gives Health Update Following Cancer Diagnosis: 'I'm Feeling Good' on April 17, 2019 at 2:55 pm
Jeopardy! host Alex Trebek shocked the world last month when he announced he had been diagnosed with Stage 4 pancreatic cancer. On Wednesday, after wrapping Season 35 of the show, he offered fans an ... […]
- After cancer diagnosis, Jeopardy! host Alex Trebek wraps up 35th season on April 17, 2019 at 2:47 pm
After his cancer diagnosis, Jeopardy! Host Alex Trebek wrapped up taping shows for the 35th season of the show. Trebek has hosted 50 episodes of Jeopardy! since he was diagnosed with stage 4 ... […]
- WATCH: ‘Jeopardy’ host Alex Trebek gives update on his progress after pancreatic cancer diagnosis. ‘I’m touched beyond words.’ on April 17, 2019 at 2:46 pm
When Alex Trebek announced in March that he had been diagnosed with stage 4 pancreatic cancer, “Jeopardy!" fans rallied to support him. Trebek vowed to stay on the job, even as he sought treatment — ... […]
- VIDEO: 'Jeopardy!' host Alex Trebek offers update after cancer diagnosis, says season 36 is coming on April 17, 2019 at 1:35 pm
DETROIT - "Jeopardy!" host Alex Trebek offered an update Wednesday about the show after he announced last month that he has stage 4 pancreatic cancer. Watch the update from Trebek below. Trebek said ... […]
- Abby Lee Miller Shares Spinal Scar Photo On 1-Year Anniversary Of Cancer Diagnosis on April 17, 2019 at 1:06 pm
In a new, emotional Instagram post, Abby Lee Miller shows her spinal surgery scar. One year ago, Abby underwent emergency spinal surgery which later told her she had cancer. Abby's specific type of ... […]
- LL Cool J wanted to give wife fibula bone following cancer diagnosis on April 17, 2019 at 7:00 am
LL Cool J wanted to give his wife his fibula bone when she was diagnosed with cancer. The 51-year-old rapper - who's real name is James Todd Smith - has opened up about his wife, Simon Smith's, battle ... […]
- After a cancer diagnosis at 30 'shook her world' this P.E.I. woman wants to spread hope on April 16, 2019 at 4:09 pm
P.E.I. native Michelle Fuller was first diagnosed with cancer in 1999 at the age of 30, when she had surgery to remove her right eye, her cheekbone and part of the roof of her mouth. She's telling her ... […]
via Bing News