Scientists have long known that restricting calories can fend off physiological signs of aging, with studies in fruit flies, roundworms, rodents and even people showing that chronically slashing intake by about a third can reap myriad health benefits and, in some cases, extend lifespan.
From a public health perspective, that advice would be impractical for many and dangerous for some.
But a new CU Boulder study published today indicates that when people consume a natural dietary supplement called nicotinomide riboside (NR) daily, it mimics caloric restriction, aka “CR,” kick-starting the same key chemical pathways responsible for its health benefits.
Supplementation also tends to improve blood pressure and arterial health, particularly in those with mild hypertension, the study found.
“This was the first ever study to give this novel compound to humans over a period of time,” said senior author Doug Seals, a professor and researcher in the Department of Integrative Physiology. “We found that it is well tolerated and appears to activate some of the same key biological pathways that calorie restriction does.”
For the study, published in the journal Nature Communications, Seals and lead author Chris Martens, then a postdoctoral fellow at CU Boulder, included 24 lean and healthy men and women ages 55 to 79 from the Boulder area.
Half were given a placebo for six weeks, then took a 500 mg twice-daily dose of nicotinamide riboside (NR) chloride (NIAGEN). The other half took NR for the first six weeks, followed by placebo.
The researchers took blood samples and other physiological measurements at the end of each treatment period.
Participants reported no serious adverse effects.
The researchers found that 1,000 mg daily of NR boosted levels of another compound called nicotinamide adenine dinucleotide (NAD+) by 60 percent. NAD+ is required for activation of enzymes called sirtuins, which are largely credited with the beneficial effects of calorie restriction. It’s involved in a host of metabolic actions throughout the body, but it tends to decline with age.
Research suggests that as an evolutionary survival mechanism, the body conserves NAD+ when subjected to calorie restriction. But only recently have scientists begun to explore the idea of supplementing with so-called “NAD+-precursors” like NR to promote healthy aging.
The Latest on: Nicotinomide riboside
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The Latest on: Nicotinomide riboside
Preliminary Results Show NIAGEN® Has Potential To Lower Blood Pressure For Individuals With Pre-Hypertension.
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Supplement Showing Promise In CardioVascular Aging
on April 7, 2018 at 5:18 am
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New NR Vitamin Promising to Address Aging in Adults
on April 6, 2018 at 11:37 pm
Summary: Nicotinamide riboside (NR), a form of vitamin B, increased levels of NAD report researchers in a new study. [This article first appeared on LongevityFacts and was updated on April 3, 2018. Author: Brady Hartman.] Researchers at the University of ... […]
UD researcher investigates role of new compound in fighting age-related diseases
on April 3, 2018 at 8:33 pm
Christopher Martens, an assistant professor of Kinesiology and Applied Physiology, is studying a naturally occurring dietary supplement, nicotinamide riboside (NR) – a novel form of vitamin B3 – and its efficacy for boosting nicotinamide adenine ... […]
Heart benefits: Supplement could slow cardiovascular ageing by mimicking calorie restriction effect
on April 3, 2018 at 6:46 am
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Nicotinamide Riboside Improves Blood Pressure and Arterial Health, Mimics Caloric Restriction: Study
on March 29, 2018 at 11:12 am
A study published in the journal Nature Communications indicates that when people consume a form of Vitamin B3 called nicotinamide riboside (NR) daily, it mimics caloric restriction, kick-starting the same key chemical pathways responsible for its health ... […]
This supplement may promote healthy arterial aging
on March 29, 2018 at 7:09 am
The researchers, at the University of Colorado Boulder, found that the supplement — called nicotinamide riboside — mimics some of the effects of caloric restriction and activates several identical biological pathways. Studies of caloric restriction ... […]
Dietary supplement shows promise for reversing cardiovascular aging
on March 29, 2018 at 2:08 am
But a new University of Colorado Boulder study published today indicates that when people consume a natural dietary supplement called nicotinomide riboside (NR) daily, it mimics caloric restriction, aka "CR," kick-starting the same key chemical pathways ... […]
Elysium Health, Inc. Challenge of ChromaDex Licensed Patent Denied by Patent Trial and Appeal Board (PTAB)
on January 21, 2018 at 4:00 pm
With a comprehensive global patent portfolio of 16 patents and applications covering compositions and methods of use for nicotinamide riboside, our patent portfolio remains strong and continues to grow.” Robert N. Fried, President and Chief Operating ... […]
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