A discovery by Queensland scientists could be the key to stopping damage caused by uncontrolled inflammation in a range of common diseases including liver disease, Alzheimer’s and gout.
University of Queensland researchers have uncovered how an inflammation process automatically switches off in healthy cells, and are now investigating ways to stop it manually when it goes awry.
“Now that we understand how this pathway naturally turns off in health, we can investigate why it doesn’t turn off in disease — so it’s very exciting,” Dr Schroder said.
Her work at IMB’s Centre for Inflammation and Disease Research focuses on inflammasomes, which are machine-like protein complexes at the heart of inflammation and disease.
“These complexes form when an infection, injury or other disturbance is detected by the immune system, and they send messages to immune cells to tell them to respond,” Dr Schroder said.
“If the disturbance can’t be cleared, such as in the case of amyloid plaques in Alzheimer’s, these molecular machines continue to fire, resulting in neurodegenerative damage from the sustained inflammation.”
Dr Schroder’s team, led by Dr Dave Boucher, discovered that inflammasomes normally work with an in-built timer switch, to ensure they only fire for a specific length of time once triggered.
“The inflammasome initiates the inflammation process by activating a protein that functions like a pair of scissors, and cuts itself and other proteins,” Dr Schroder said.
“What we’ve found is that after a period of time this protein cuts itself a second time to turn off the pathway, so if we can tweak this system we may be able to turn it off manually in disease.”
Dr Schroder’s laboratory has begun studying the inflammasome in fatty liver disease, a rapidly growing health issue due to the increasing global incidence of obesity and diabetes.
“In some patients with this condition the liver becomes increasingly fatty and inflamed, and this can lead to cirrhosis – which can require liver transplantation – or even liver cancer.”
Compounds to block inflammasome have been developed by IMB researchers including Dr Schroder, and are being commercialised by start-up drug development company Inflazome Ltd.
The research, published in the Journal of Experimental Medicine (DOI: 10.1084/jem.20172222), was supported by the Australian Research Council, and involved laboratories at IMB and the UQ School of Chemistry and Molecular Biosciences.
Imaging for the project was performed in the IMB Cancer Biology Imaging Facility, funded by the Australian Cancer Research Foundation.
Additional video: inflammasome animation on YouTube.
The Latest on: Uncontrolled inflammation
via Google News
The Latest on: Uncontrolled inflammation
- Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation on April 17, 2019 at 2:22 am
Macrophage-orchestrated, low-grade chronic inflammation plays a pivotal role in obesity and ... For HFD-induced obesity model, experimental 7–8-week-old KO mice and their control mice were fed with ... […]
- Statin exposure associated with idiopathic inflammatory myositis on April 15, 2019 at 6:39 am
Study design: Retrospective, population-based, case-control study. Setting ... significant association between statin use and the incidence of idiopathic inflammatory myositis, which suggests that ... […]
- New Studies Recommend Some Ways to Have an Anti-Inflammatory Lifestyle on April 15, 2019 at 2:40 am
Inflammation can also be managed or reduced ... In a study, the researchers had 80 participants divided into bromelain and control groups. It was found that those treated with bromelain reported ... […]
- Gene expression profile in patients with Gaucher disease indicates activation of inflammatory processes on April 15, 2019 at 2:14 am
Table 3 Statistically significant differences in the ddCt values - analysis of results obtained in GD patients, NPC patients, and control persons ... indicating an important role of anti-inflammatory ... […]
- Removing damaged mitochondria may relieve chronic inflammatory conditions on April 12, 2019 at 8:01 am
Inflammation is a protective process that the body uses to ... At the time, colleague Elsa Sanchez-Lopez had been studying how macrophages control their uptake of a critical nutrient called choline ... […]
- THIS TURMERIC-CARROT-BLACK PEPPER SOUP (RECIPE) FIGHTS INFLAMMATION, ALZHEIMER’S DISEASE, AND CANCER on April 12, 2019 at 2:21 am
The potent antioxidant and anti-inflammatory properties of curcumin ... had reduced pain and increased mobility compared to the control group. Earlier research also found that a turmeric extract ... […]
- In mice, eliminating damaged mitochondria alleviates chronic inflammatory disease on April 11, 2019 at 12:31 pm
To test their new ability to control NLRP3 inflammasome in a living system, the researchers turned to mice. They discovered that treatment with ChoK inhibitors prevented acute inflammation caused by ... […]
- NASA’s Twins Study: A great control, but a sample size of one on April 11, 2019 at 12:20 pm
The existence of an identical twin offers a good control for genetic changes ... metabolites that indicate problems with DNA damage and inflammation. Looking at the DNA itself, it was clear ... […]
- Tart cherry juice helps reduce inflammation in older adults on April 10, 2019 at 5:14 am
who were randomly assigned to consume 480 milliliters of tart cherry juice or control drink daily for 12 weeks. In addition, blood biomarkers of inflammation and oxidative stress were assessed at the ... […]
via Bing News