Aging or impaired brains can once again form lasting memories if an enzyme that applies the brakes too hard on a key gene is lifted, according to University of California, Irvine neurobiologists.
“What we’ve discovered is that if we free up that DNA again, now the aging brain can form long-term memories normally,” said senior author Marcelo Wood, UCI’s Francisco J. Ayala Chair in Neurobiology & Behavior, who will present the findings at the American Association for the Advancement of Science’s annual meeting, in Austin, Texas. “In order to form a long-term memory, you have to turn specific genes on. In most young brains, that happens easily, but as we get older and our brain gets older, we have trouble with that.”
That’s because the 6 feet of DNA spooled tightly into every cell in our bodies has a harder time releasing itself as needed, he explained. Like many body parts, “it’s no longer as flexible as it used to be.” The stiffness in this case is due to a molecular brake pad called histone deacetylase 3, or HDAC3, that has become “overeager” in the aged brain and is compacting the material too hard, blocking the release of a gene called Period1. Removing HDAC3 restores flexibility and allows internal cell machinery to access Period1 to begin forming new memories.
Researchers had previously theorized that the loss of transcription and encoding functions in older brains was due to deteriorating core circadian clocks. But Wood and his team, notably postdoctoral fellow Janine Kwapis, found that the ability to create lasting memories was linked to a different process – the overly aggressive enzyme blocking the release of Period1 – in the same hippocampus region of the brain.
That’s potentially good news for developing treatments. “New drugs targeting HDAC3 could provide an exciting avenue to allow older people to improve memory formation,” Wood said.
The Latest on: Memory restoration
FUN HOME - 4th Wall Theatre Non Equity Auditions
on March 15, 2018 at 12:14 pm
The musical takes place twenty-five years later, as Alison, now 44, is creating a graphic novel exploring all the moments in her memory that led up to her ... and historic home restoration fanatic, he is charming on the surface, with deep layers of shame ... […]
One Thing Donald Trump Would Like Is Freedom From the Press
on March 15, 2018 at 4:40 am
More than any president in living memory, Donald Trump has conducted a dogged ... constitutional hardball because they are drawn to “narratives of debasement and restoration,” which suggest that something has gone fundamentally awry in the republic ... […]
The 5 Best Purchases for a Good Night's Sleep
on March 14, 2018 at 12:50 pm
Sleep plays a crucial role in every aspect of our lives: it impacts our health, stress levels, mood, memory, work performance and our ... He recommends people consider restoration before replacement. Another way people may overspend is by making purchase ... […]
What Will Be The Fate Of Marjory Stoneman Douglas' Grove Home?
on March 13, 2018 at 2:22 pm
Credit Florida Memory Project Residents like Long hope Tuesday’s public ... in conjunction with a state restoration strategies plan, provides 350,000 acre-feet of above-ground storage. Every time it rains, storm water drains throughout South Florida ... […]
The unapologetic hunter
on March 13, 2018 at 10:29 am
I believe President Theodore Roosevelt was referring to that genetic memory when he wrote ... with all they contribute to wildlife conservation and habitat restoration. Smokey Merkley was raised in Idaho and has been hunting since he was 10 years old. […]
Stained glass from Franklin church to undergo restoration
on March 11, 2018 at 3:43 pm
Across the bottom, in blue glass with purple embellishments, is an inscription in glass: In Memory of Deborah Morse, 1821-1882. The removal of the windows is part of a $500,000 ongoing restoration campaign at the church at 171 Main St., which dates to 1895. […]
Kulsum Begum’s memory erodes with masjid cracks
on March 10, 2018 at 7:34 pm
CHARMINAR: The fabled mosque of Kulsumpura, built by Princess Kulsum Begum, daughter of Sultan Mohammed Qutub Shah, is dying a slow death because no efforts are being made for its restoration or conservation. Built between 1612 and 1626 AD, the Jama Masjid ... […]
Greek goddess on her way to Alabama for restoration
on March 10, 2018 at 5:20 am
“The irony is, when we were searching for restoration companies ... In other business, the board approved: • $19,000 in memory of the Granite Mountain Hotshots to the Arizona Wildfire and Incident Management Academy for scholarships. […]
Restoration underway at Detroit's historic Belle Isle Boat House
on March 6, 2018 at 7:56 am
A benefit is being held this week, on Saturday night. Find tickets to the event here. "With well over a half-million invested in ongoing renovations, the memory of the historic boat house’s original grandeur can be felt radiating throughout the ... […]
Lost Sphear’s Memory Restoration Feels Both Classic And Original
on February 1, 2018 at 12:25 pm
Tokyo RPG Factory has been trying to make games that remind people of past JRPGs. I am Setsuna did its best to channel Chrono Trigger, and now Lost Sphear is doing the same. Yet, at the same time, Lost Sphear is trying to strike out on its own and do ... […]
via Google News and Bing News