An old drug supercharged by University of Queensland researchers has emerged as a new antibiotic that could destroy some of the world’s most dangerous superbugs.
The supercharge technique , led by Dr Mark Blaskovich and Professor Matt Cooper from UQ’s Institute for Molecular Bioscience (IMB), potentially could revitalise other antibiotics.
Antibiotic-resistant bacteria – superbugs – cause 700,000 deaths worldwide each year, and a UK government review has predicted this could rise to 10 million by 2050.
Dr Blaskovich said the old drug, vancomycin, was still widely used to treat extremely dangerous bacterial infections, but bacteria were becoming increasingly resistant to it.
“The rise of vancomycin-resistant bacteria, and the number of patients dying from resistant infections that cannot be successfully treated, stimulated our team to look at ways to revitalise old antibiotics,” Dr Blaskovich said.
“We did this by modifying vancomycin’s membrane-binding properties to selectively bind to bacterial membranes rather than those of human cells, creating a series of supercharged vancomycin derivatives called vancapticins.”
The rebooted vancomycin has the potential to treat methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
Professor Cooper said pharmaceutical companies had departed the antibiotic discovery field because new antibiotics were difficult to find and were not as lucrative as cholesterol-lowering medications or cancer treatments.
“Hence many scientists are re-engineering existing drugs to overcome bacterial resistance, rather than searching for new drugs,” he said.
“Drug development is normally focused on improving binding to a biological target, and rarely focuses on assessing membrane-binding properties.
“This approach worked with the vancapticins, and the question now is whether it can be used to revitalise other antibiotics that have lost effectiveness against resistant bacteria.
“Given the alarming rise of multi-drug resistant bacteria and the length of time it takes to develop a new antibiotic, we need to look at any solution that could fix the antibiotic drug discovery pipeline now,” Professor Cooper said.
The Latest on: Supercharged antibioticx
Bioprocess Technology Market – Ongoing Review on Functions 2025
on January 17, 2019 at 12:06 am
Bioprocess technology finds application in end use industries for manufacture of biomaterials such as pharmaceutical supplements, antibiotics ... to business entities keen on succeeding in today's sup... […]
Nokomis drum circle weathers red tide
on January 13, 2019 at 6:00 am
But this time around, its punch seemed supercharged. During the 2018 summer sea turtle ... The wound required two rounds of antibiotics and four weeks to clear. Friends from the Midwest visited over s... […]
Is Renewable Energy Enough To Stop Global Warming? What About Animal Agriculture?
on December 10, 2018 at 1:48 am
antibiotics produced in the US, antibiotic-resistant bacteria, veganic food production, world hunger, tax subsidies for animal agriculture, hidden costs of animal agriculture including subsidized fast ... […]
Genetic study of soil organisms reveals new family of antibiotics
on February 12, 2018 at 4:00 pm
Much more testing with the new family of antibiotics is required before clinical trials, of course, but for now, the researchers are optimistic, suggesting many more members of the family are likely t... […]
on January 13, 2018 at 6:22 am
There's a lot of worry in the medical community about antibiotic resistant bugs - these bacteria cause 700,000 deaths a year and that number's expected to get a lot worse in the years to come. So a re... […]
New supercharged antibiotics could help win war against superbugs
on January 11, 2018 at 8:15 pm
An old drug supercharged by researchers at the University of Queensland may be a new weapon in the battle against some of the world’s most dangerous superbugs, with researchers claiming it could destr... […]
Supercharged antibiotics could turn tide against superbugs
on January 4, 2018 at 4:00 pm
An old drug supercharged by University of Queensland researchers has emerged as a new antibiotic that could destroy some of the world's most dangerous superbugs. The supercharge technique , led by Dr. ... […]
There's An Antibiotic Apocalypse That's Going to Send Us Back to the Dark Ages of Medicine
on November 13, 2017 at 8:20 am
The bacteria responsible for the plague spreading in Madagascar can be treated with antibiotics—for now. But that could change. Some are concerned the infection could become resistant to those antibio... […]
Drugs Supercharged With Quantum Dots Could Reverse Antibiotic Resistance
on October 3, 2017 at 5:00 pm
Bacteria that are resistant to current antibiotics are a growing—and alarming—problem. A new solution comes from an unexpected place: light-activated chemicals that supercharge antibiotics so that bac... […]
Take That, Superbug! New Supercharged Antibiotic to the Rescue
on May 31, 2017 at 11:45 am
There's a new antibiotic in town and superbugs are running scared. That's welcome news, because lately we've been witnessing a nightmare scenario unfolding before our eyes: bacteria that can not be ki... […]
via Google News and Bing News