Researchers at Instituto de Medicina Molecular (iMM) João Lobo Antunes have found that manipulating a single RNA molecule is enough to revert celular ageing.
Throughout time all cells age gradually, contributing to the development of several diseases. Inducing cellular regeneration is one of the strategies used to fight diseases associated with cellular ageing. However, aged cells tend to be highly resistant to any type of manipulation intended to induce regeneration.
Ribonucleic acid, or RNA, is responsible for protein synthesis inside cells. However, a specific type of molecule named non-coding RNA is never translated into protein. In fact, since the mapping of the human genome in 2001 it is known that only about 2% is actually translated into proteins.
Now, the team led by Bruno de Jesus and Maria do Carmo-Fonseca, used a genetically modified mouse model to study cellular ageing and regeneration. They found that cells derived from the skin of old mice produced higher amounts of a long non-coding RNA molecule named Zeb2-NAT when compared to cells from young mice. By reducing the amount of this specific RNA molecule, it was possible to efficiently regenerate old cells.
“These results are an important step to be able to regenerate diseased tissues in older people,” said Bruno de Jesus.
The Latest on: Reverting cellular ageing
Marylanders are more liberal than Gov. Hogan. But they like him anyway.
on June 5, 2018 at 9:00 pm
“The support for Hogan really suggests that people are paying attention to what’s happening on the ground and not just reverting to their partisan ... said she is worried about overcrowding, aging schools and underpaid teachers. If Hogan does not ... […]
Diabetes results from a breakdown of epigenetic control
on June 5, 2018 at 6:35 am
With a share of over 95 percent, most patients are suffering from type 2 diabetes, which usually occurs in old age and is associated with obesity ... They lose their most specialized functions and revert to a state similar to their immediate developmental ... […]
The ambitious quest to cure ageing like a disease
on February 4, 2018 at 10:03 pm
There are seven biological factors De Grey argues are predominantly responsible for cellular ... to revert their cells to what they were like when they were in their youth, buying them extra time. The idea is that someone who is treated at the age of ... […]
Scientists discover molecule that could revert celular ageing
on January 8, 2018 at 4:00 pm
Researchers at Instituto de Medicina Molecular (iMM) João Lobo Antunes have found that manipulating a single RNA molecule is enough to revert cellular aging. Over time, cells age, contributing to the development of several diseases. Inducing cellular ... […]
Why your biological age may hold the key to reversing the ageing process
on August 3, 2017 at 5:05 pm
The Turritopsis dohrnii, or “immortal jellyfish”, for instance, can revert ... where biological age comes in – it attempts to identify how far along we are in this process. It’s not a simple task, because no single measure of cellular ageing ... […]
Salk Scientists Reverse Signs Of Aging In Mice
on December 14, 2016 at 4:00 pm
San Diego scientists have seemingly turned back time for aging mice. Their new research, published Thursday in Cell, demonstrates that biological hallmarks of aging can be reversed in living animals through cellular ... it can also revert cells in a ... […]
Banking on stem cells at Cellular Dynamics International
on December 20, 2015 at 4:00 am
Cellular Dynamics manufactures mass quantities of stem cells using adult tissue or blood samples, reverting them into their embryonic ... cells after a heart attack or you have eye damage from age-related macular degeneration, you pull your own cells ... […]
The animals and plants that can live forever
on June 19, 2015 at 10:56 am
Similar proteins might help plants like the bristlecone pine avoid cellular ageing, allowing some of them to live for ... Uniquely, even a sexually mature adult can revert to an immature polyp, "thus escaping death and achieving potential immortality". […]
This pill could give your brain the learning powers of a 7-year-old
on January 5, 2014 at 4:00 pm
But what if it were possible for the adult mind to revert back to a more porous state of learning? That's the subject of an investigation by Takao Hensch, a professor of molecular and cellular biology ... would at their age. In other words, he gave people ... […]
CTIA/FCC could outlaw cellular repeaters AKA "jammers"
on January 17, 2008 at 4:00 pm
It means places like my dead zone house and Arrington’s pad will be completely off the cellular grid, reverting many of us to Stone Age. Well I, for one, refuse to eat uncooked mastodon meat. Watch this space for more info. […]
via Google News and Bing News