Oregon State University scientists have developed a nanomedicine platform for cancer that can help doctors know which tissue to cut out as well as kill any malignant cells that can’t be surgically removed.
The platform allows for greater precision and thoroughness in cancer treatment.
Here’s how it works:
Nanoparticles tightly loaded with a dye compound are administered systemically – injected intravenously or into the peritoneum, the abdominal cavity. When they reach the tumor site, the tumor’s intracellular environment effectively flips the switch on the compound’s fluorescence.
That enables detection by a near infrared (NIR) imaging system that helps surgeons know in real time what needs to be removed.
Any glowing areas that can’t be cut out are given phototherapy – irradiated with a near infrared laser, which causes the nanoparticles to heat up and kill the residual cancer cells.
The findings by researchers in the OSU/OHSU College of Pharmacy and OSU College of Veterinary Medicine were published this month in Theranostics.
The nanomedicine platform consists of silicon naphthalocyanine (SiNc) densely packed in biodegradable PEG-PCL nanoparticles. Because the SiNc is engineered to be non-fluorescent initially – until the tumor activates the fluorescence by loosening the packing – it doesn’t cause any non-cancerous tissue to glow.
Corresponding authors Olena Taratula and Oleh Taratula of the Department of Pharmaceutical Sciences and their collaborators evaluated the platform in vitro and in two different mouse models, including one that mimicked ovarian intraperitoneal metastasis.
The research team operated on the mice using real-time imaging, which showed that the new nanoparticles are compatible with a standard, FDA-approved imaging system. The efficacy of the phototherapy was also demonstrated in vivo.
“The nanoplatform system is quite simple but quite effective,” Olena Taratula said.
Subsequent laboratory testing of the platform will include rats, she said, followed by testing on dogs that are already scheduled for cancer surgeries at the College of Veterinary Medicine.
“They’re going to do surgery on those dogs anyway, and they can use our nanomedicine platform as an additional tool to see if they can identify the cancer cells,” Taratula said.
The Latest on: Flourescent nanomedicine
- ITGA2 as a potential nanotherapeutic target for glioblastoma on April 17, 2019 at 2:10 am
GBM-specific toxicity of ITGA2 antibody-directed liposomes This novel precision nanomedicine has the potential to load ... and were then examined using a Leica TCS SP5 confocal fluorescent microscope ... […]
- Liposomal Nanomedicine for Breast Cancer Therapy on March 28, 2019 at 5:00 pm
Multifunctional liposomes, which utilize molecular alterations/expressions by tumor cells, remains the thrust area of research in the field of nanomedicine for breast cancer therapy. […]
- New optical imaging system could be deployed to find tiny tumors on March 7, 2019 at 6:37 am
Researchers have developed a near-infrared fluorescent optical imaging system that could ... the Marble Center for Cancer Nanomedicine, the Koch Institute Support (core) Grant from the National Cancer ... […]
- Texas Center For Cancer Nanomedicine Targets Two Tough Cancers on November 6, 2018 at 4:00 pm
A $16-million, five-year grant by the National Cancer Institute's nanomedicine initiative blends the expertise ... Near-infrared technology pinpoints fluorescent probes deep within living tissue; may ... […]
- Nanomedicine 2018 Global Market Expected to Grow at CAGR 17.1% and Forecast to 2022 on October 26, 2018 at 5:21 am
Nanomedicine uses nano-sized tools for the diagnosis ... Therapeutic Application Analysis: Nanomedicines are used as fluorescent markers for diagnostic and screening purposes. Moreover, nanomedicines ... […]
- New imaging technique aims to find even the smallest of cancerous tumors on October 22, 2018 at 7:08 am
The research – published recently in the International Journal of Nanomedicine – expanded upon a technique known as multi-photon imaging, which uses near-infrared light to excite fluorescent molecules ... […]
- Tel Aviv scientist lights the way in detecting cancer cells on October 12, 2018 at 8:31 am
The research of Professor Ronit Satchi-Fainaro, Ph.D., head of Tel Aviv University’s Cancer Research and Nanomedicine Laboratory ... functions as a polymer that connects cancer cells to a fluorescent ... […]
- The potential and the pitfalls of nanomedicine on August 7, 2018 at 9:58 am
Whether these beliefs are based on facts or hope, many corporations and governments are willing to invest a great deal of money to find out what happens when nanotechnology is used for medical ... […]
- Fluorescent nanomedicine can guide tumor removal, kill remaining cancer cells on December 20, 2017 at 4:00 pm
Oregon State University scientists have developed a nanomedicine platform for cancer that can help doctors know which tissue to cut out as well as kill any malignant cells that can't be surgically ... […]
via Google News and Bing News