A new study shows that a 70-year-old malaria drug can block immune cells in the liver so nanoparticles can arrive at their intended tumor site, overcoming a significant hurdle of targeted drug delivery, according to a team of researchers led by Houston Methodist.
Many cancer patients do not respond to chemotherapies because the drugs never reach the cancer cells. Even in nanomedicine, which is one of the best new methods for delivering drugs to a tumor, only about one percent of a dose of nanoparticles will successfully arrive at the intended tumor site, while the rest are filtered out by the immune cells of the liver and spleen.
Using chloroquine, the researchers not only increased the circulation of nanoparticles in the body, but also reduced the body’s filtration of nanoparticles, as well as improved drug delivery to breast tumors. The study was recently published in Scientific Reports, a research journal from the Nature Publishing Group.
Led by Mauro Ferrari, Ph.D., president and CEO of the Houston Methodist Research Institute, and Joy Wolfram, Ph.D. (now at Mayo Clinic’s campus in Jacksonville, Florida), the research showed that chloroquine interfered with immune cells called macrophages, which are used by the body to identify microscopic foreign objects and destroy them.
In this study, mice models received injections of chloroquine, followed by an injection of nanoparticles. Chloroquine decreased the macrophages’ ability to clean up the nanoparticles. The findings are significant, because the nanoparticles not only remained in circulation, but also accumulated in mouse tumors, as well as in the lungs of healthy mice, suggesting that the approach also may enhance treatment for lung diseases.
Chloroquine was invented in the 1940s for the prevention and treatment of malaria. Since it mildly suppresses the immune system, the drug also is used in some autoimmune disorders, such as rheumatoid arthritis and lupus. Apart from this research, the drug is also being studied in other cancers, such as triple-negative breast cancer and pancreatic cancer.
Ferrari, considered one of the founders of nanomedicine and transport oncophysics (the physics of mass transport within a cancer lesion), says researchers and clinicians need to understand the limitations of transport mechanisms to identify effective immunotherapy treatments for patients.
The Latest on: Drug delivery
See the results of east county drug-delivery bust
on March 16, 2018 at 4:20 pm
See the results of east county drug-delivery bust Firearms, ammunition and drug paraphernalia were collected after the bust of a heroin delivery service that operated primarily in east Ventura County. Check out this story on vcstar.com: http://www.vcstar ... […]
Drug Makers use Nanotechnology to Improve Delivery and Dosing
on March 16, 2018 at 6:17 am
In order to advance the delivery of specialized medicines and dosage, scientists are looking to improvements including Nanotechnology as part of the new vanguard of autonomous drug delivery technologies. Companies looking to advance new drug delivery ... […]
Global ocular drug delivery technology market is expected to be driven by increasing prevalence of eye diseases
on March 16, 2018 at 3:09 am
Mar 16, 2018 (marketresearch.biz via COMTEX) -- Eye diseases such as cataract, glaucoma, diabetic retinopathy etc. are not treatment properly may cause loss of vision. Manufacturers are developing several novel technologies for ocular drug delivery as it ... […]
Nasal Drug Delivery Market 2018 Scope by Spray and Nebulizers Delivery Technologies with Leading Companies Profiles – ME&A Forecast till 2022
on March 16, 2018 at 2:11 am
Geographically, nasal drug delivery market is segmented into four key regions: the Americas, Europe, Asia Pacific, and the Middle East & Africa. The Americas is further segmented into North America and South America. And North America is segmented into the ... […]
Inaugural West Coast Drug Delivery Event Announced for May 2018
on March 16, 2018 at 1:53 am
The Conference Forum is pleased to bring the inaugural Drug Delivery Design & Partnering conference to the Mark Hopkins Intercontinental Hotel in San Francisco on May 21-22, 2018. Organized by the company's PODD team, this west coast event is dedicated to ... […]
Drug Delivery Resulting in Death Arrest
on March 15, 2018 at 3:54 pm
MONROE COUNTY (WBRE/WYOU-TV) A Monroe County man is in jail accused of selling a deadly batch of heroin. 25-year-old Sean Ingino of Mount Pocono is charged with "drug delivery resulting in death". Police say, last October, he sold fentanyl-laced heroin to ... […]
Extracellular Vesicles Could Be Personalized Drug Delivery Vehicles
on March 15, 2018 at 7:59 am
Creating enough nanovesicles to inexpensively serve as a drug delivery system may be as simple as putting the cells through a sieve, according to an international team of researchers who used mouse autologous—their own—immune cells to create large ... […]
Breakthrough brings targeted drug delivery within ARMM’s reach
on March 14, 2018 at 10:52 am
ARMMs deliver p53 into spleen tissue of mice. TUNEL staining (brown) indicates p53-dependent cell death in response to DNA damage. March 14, 2018—Scientists at Harvard T.H. Chan School of Public Health demonstrated a new vesicle-based system for ... […]
Extracellular vesicles may serve as drug delivery vehicles for cancer treatment
on March 13, 2018 at 5:33 pm
Creating enough nanovesicles to inexpensively serve as a drug delivery system may be as simple as putting the cells through a sieve, according to an international team of researchers who used mouse autologous -- their own -- immune cells to create large ... […]
Lab surprised to find its drug-delivery system can help even without drugs
on March 13, 2018 at 8:51 am
A synthetic, injectable hydrogel developed to deliver drugs and encourage tissue growth turns out to have therapeutic properties all its own. Researchers in the Rice lab of chemist and bioengineer Jeffrey Hartgerink had just such an experience with the ... […]
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