Instant coffee and powdered milk are produced by spray drying. Fraunhofer researchers have adapted this technique to the tricky question of incorporating insoluble substances in core-shell particles. The new method helps reduce the concentration of active ingredients in therapeutic medications.
Encapsulation is used in cosmetics and pharmaceuticals to protect active ingredients against external influences such as aggressive gastric acid. Another use of encapsulation is to control the release of active ingredients inside the body: depending on the permeability of the shell material, the medication is delivered gradually rather than all at once. Because such systems release multiple, smaller doses over an extended period of time, the drug therapy is better tolerated and easier to administer. In some cases, it means taking just one pill a day instead of three.
Insoluble substances are a problem
The first step of the encapsulation process involves dissolving the active ingredient in a liquid medium and mixing it with the shell material. Then the solution is piped to an orifice in the center of a nozzle surrounded by an annular channel through which compressed air is injected at high speed. The pressure disperses the solution into an aerosol of fine droplets, which is then sprayed into a drying cylinder. Here, the liquid evaporates, leaving behind a fine powder of core-shell particles. The problem is that it is difficult to mix insoluble substances with other materials. This limits the choice of shell materials that can be used to produce the particles.
Three-way nozzle permits endless combinations of materials
“For this reason, we use a three-way nozzle to implement spraying. Its advantage is that it permits two substances to be fed separately to the nozzle. The shear forces mix the substances together at the orifice of the nozzle, creating an aerosol containing both materials,” explains Michael Walz, who developed and optimized the new technique with his colleague Dr. Achim Weber at the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart.
This system permits endless combinations of materials, enabling the controlled release of active ingredients to be adapted to different applications. “We can modify the particle size and encapsulation efficiency by selecting the appropriate substances and by varying the concentration of the solution, the liquid volume flow, the drying temperature, and the pressure applied to the nozzle. This gives us the capability to respond to almost any customer requirement and develop solutions tailored to their needs,” says Weber.
The new process for the encapsulation of active ingredients could be of interest to fertilizer manufacturers and food processing companies as well as the cosmetics and pharmaceutical industries.
The Latest on: Drug delivery
- A Caterpillar Robot for Drug Delivery? Ya, That's a Thing on October 5, 2018 at 10:55 am
Drug delivery is a significant part of medical research since a drug cannot work if it cannot access the part of the body where it's needed. Nanotechnology, including quantum dots and miniature roboti... […]
- Blink Health launches free Rx home delivery on October 5, 2018 at 9:56 am
Blink Health said patients who use its app can save up to 80% on generic prescription medications compared to estimated retail prices without prescription drug coverage. Blink’s new home delivery serv... […]
- Topical Drug Delivery Market Forecast 2017 - 2025 : Janssen Global Services, LLC, Galderma S.A., and 3M Drug Delivery Systems on October 4, 2018 at 4:49 am
Topical drugs delivery includes treatment of body surface such as outer membrane or skin. The drugs are in the form of solid, semi-solid, liquid, gel, and transdermal patches. Topical drugs such as as... […]
- Pulmonary Drug Delivery Market worth 52.37 Billion USD by 2021 according to new research report on October 3, 2018 at 5:37 pm
According to the new market research report "Pulmonary Drug Delivery Market by Formulation (Type (Solution, Suspension, Dry powder), Device Type (Metered dose, Dry Powder, Nebulizer)), Canister (Plain ... […]
- New computer model designs a drug delivery strategy to fight cancer on October 3, 2018 at 1:35 pm
A better understanding of how nanoparticles move from the bloodstream into a tumor could eventually lead to more effective cancer treatment. Stanford researchers have created a computer simulation, va... […]
- Medherant wins grant to support manufacturing program for transdermal drug-delivery patches on October 3, 2018 at 7:19 am
Medherant said today that it was awarded a Medicines Manufacturing Grant from Innovate UK to support the manufacturing of transdermal drug-delivery patches. The company plans to expand its pilot-scale ... […]
- Global Drug Delivery Devices Market Set to Grow at a Healthy CAGR during 2018-2025 on October 3, 2018 at 2:08 am
Global Drug Delivery Devices Market 2018-2025: The global drug delivery devices market has advanced over the six decades; initially pills were emphasized on, but in the last twelve years, drugs delive... […]
- Sperm-inspired robots could be the next big thing in drug delivery on October 2, 2018 at 2:49 pm
Scientists in the United Kingdom have turned to the humble human sperm in their quest to design the ultimate swimming robot. Made of a tiny magnetic head and squiggly elastic tail, the flea-size drone... […]
- Lancaster man already charged with having 600 bags of heroin now accused of drug delivery resulting in death on October 2, 2018 at 7:28 am
LANCASTER — A 27-year-old Lancaster man already charged with having more than 600 bags of heroin on him during a traffic stop in July is now also facing a charge of drug delivery resulting in ... […]
- A multi-legged mini-robot made for drug delivery on October 2, 2018 at 7:14 am
Soft robots come in many shapes and sizes. Here is one of the latest, developed at the City University of Hong Kong. Its standout feature is a set of tiny caterpillar-like legs that can carry ... […]
via Google News and Bing News