Photo Fraunhofer IGB
Core-shell particle
Instant coffee and powdered milk are produced by spray drying. Fraunhofer researchers have adapted this technique to the tricky question of incorporating insoluble substances in core-shell particles. The new method helps reduce the concentration of active ingredients in therapeutic medications.
Encapsulation is used in cosmetics and pharmaceuticals to protect active ingredients against external influences such as aggressive gastric acid. Another use of encapsulation is to control the release of active ingredients inside the body: depending on the permeability of the shell material, the medication is delivered gradually rather than all at once. Because such systems release multiple, smaller doses over an extended period of time, the drug therapy is better tolerated and easier to administer. In some cases, it means taking just one pill a day instead of three.
Insoluble substances are a problem
The first step of the encapsulation process involves dissolving the active ingredient in a liquid medium and mixing it with the shell material. Then the solution is piped to an orifice in the center of a nozzle surrounded by an annular channel through which compressed air is injected at high speed. The pressure disperses the solution into an aerosol of fine droplets, which is then sprayed into a drying cylinder. Here, the liquid evaporates, leaving behind a fine powder of core-shell particles. The problem is that it is difficult to mix insoluble substances with other materials. This limits the choice of shell materials that can be used to produce the particles.
Three-way nozzle permits endless combinations of materials
“For this reason, we use a three-way nozzle to implement spraying. Its advantage is that it permits two substances to be fed separately to the nozzle. The shear forces mix the substances together at the orifice of the nozzle, creating an aerosol containing both materials,” explains Michael Walz, who developed and optimized the new technique with his colleague Dr. Achim Weber at the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart.
This system permits endless combinations of materials, enabling the controlled release of active ingredients to be adapted to different applications. “We can modify the particle size and encapsulation efficiency by selecting the appropriate substances and by varying the concentration of the solution, the liquid volume flow, the drying temperature, and the pressure applied to the nozzle. This gives us the capability to respond to almost any customer requirement and develop solutions tailored to their needs,” says Weber.
The new process for the encapsulation of active ingredients could be of interest to fertilizer manufacturers and food processing companies as well as the cosmetics and pharmaceutical industries.
Learn more: Spray drying: Perfect dosing thanks to drug capsules
The Latest on: Drug delivery
Opening arguments made in drug-delivery death trial - Reading Eagle
July 12, 2018 - Burton was arrested in June 2016 and charged with drug delivery resulting in death and other related charges. He is being held in the Montgomery County Correctional Facility after being unable to post $1 million bail. Contact Matt Carey: 610-371-5038 ...
July 11, 2018 - Europe Injectable Drug Delivery Market report contains an in-depth profiling of the key market players, along with the recent developments (new product launches, partnerships, agreements, collaborations, and joint ventures) and strategies adopted by ...
July 11, 2018 - Conventional methods of nasal drug delivery, such as drops and sprays, fail to deliver therapeutics far enough into the nasal cavity and are rapidly removed by the body's cleaning mechanisms. Preveceutical's soluble gel formulations aim to resolve this ...
July 11, 2018 - Previous preclinical research has shown that extracorporeal devices can be used to enhance the delivery and distribution of systemically administered anticancer drugs, resulting in increased intratumoural concentrations. We aimed to assess the safety ...
Ultrasound remotely bursts heat-sensitive capsules, delivering drugs directly to tumors - New Atlas
July 11, 2018 - A promising new cancer drug delivery system has successfully passed early human safety trials. The treatment delivers cancer drugs in heat-activated capsules to tumors in the liver and then uses a focused ultrasound beam to remotely trigger the ...
Trial begins in drug-delivery death of Pottstown woman - Reading Eagle
Hilltown Twp. man facing charges in relation to fatal drug delivery - WFMZ Allentown
July 10, 2018 - HILLTOWN TWP., Pa. - A Hilltown Township man is facing charges in relation to a drug delivery resulting in death. Police say a joint investigation led them to 21-year-old William Frank Brennan, who is allegedly the source of the fentanyl that caused ...
Focused Ultrasound Increases Drug Delivery to Liver Tumors - Medscape
July 9, 2018 - "Administering the drug alone even as a liposomal formulation is generally not enough to kill tumor cells. Our study shows that focused ultrasound–triggered targeted delivery of doxorubicin from thermosensitive liposomes pushes the local concentrations ...
Attempted drug delivery leads to arrests in Jefferson City - Jefferson City News Tribune
July 9, 2018 - Court records show Abbott has had numerous arrests for narcotics, including five pending charges for drug distribution. He also has been arrested and convicted for second-degree murder and armed robbery. Herman has previous drug convictions in 2007, ...
-
Opening arguments made in drug-delivery death trial
on July 11, 2018 at 9:01 pm
NORRISTOWN - Prosecutors said Wednesday that a Philadelphia man delivered the drugs that killed a Pottstown woman. The defendant's attorney countered that authorities can't prove her client delivered ... […]
-
Hilltown Twp. man facing charges in relation to fatal drug delivery
on July 11, 2018 at 4:36 pm
HILLTOWN TWP., Pa. - A Hilltown Township man is facing charges in relation to a drug delivery resulting in death. Police say a joint investigation led them to 21-year-old William Frank Brennan, who is ... […]
-
Global Drug and Gene Delivery Systems Market CAGR of over 6% from 2017 to 2025 To Reach Over US$ 917 Bn by 2025
on July 11, 2018 at 5:05 am
Latest Update "Drug and Gene Delivery Systems Market - Global Industry Analysis, Size, Share, Volume, Growth, Trends, and Forecast 2017-2025" with Industries Survey | Global Current Growth and Future. ... […]
-
TFF Pharmaceuticals Receives Notice of Allowance for New Foundational Patent Broadly Covering Novel Inhaled Dry Powder Drug Delivery Platform
on July 11, 2018 at 3:52 am
AUSTIN, Texas, July 11, 2018 /PRNewswire/ -- TFF Pharmaceuticals, Inc., an early-stage biopharmaceutical company focused on developing and commercializing innovative drug products for the treatment of ... […]
-
Trial begins in drug-delivery death of Pottstown woman
on July 10, 2018 at 9:01 pm
NORRISTOWN - Jury selection in the trial of a Philadelphia man accused of providing fentanyl to a Pottstown woman that led to her death began Tuesday. Harold Burton, 38, is charged with drug delivery ... […]
-
Central Nervous System Drug Delivery Specialists Market to Develop Rapidly by 2019
on July 10, 2018 at 4:00 pm
Despite the advances in brain and central nervous system disorders remains the world’s leading cause of disability. The delivery of drugs to central nervous system remains a challenge for the treatmen... […]
-
Attempted drug delivery leads to arrests in Jefferson City
on July 10, 2018 at 5:37 am
Two men have been charged after an attempted drug delivery in Jefferson City early Saturday morning. Jeffery Abbott Jr., 29, of Jefferson City, is charged with delivery of a controlled substance. Paul ... […]
-
Focused Ultrasound Increases Drug Delivery to Liver Tumors
on July 9, 2018 at 3:56 pm
A heat-sensitive liposomal preparation loaded with doxorubicin (multiple brands) was able to deliver its contents directly to liver lesions when the temperature was raised above 39.5 °C by focused ult... […]
-
Mylan launches generic drug-delivery patch for dementia patients
on July 9, 2018 at 7:00 am
Mylan (NSDQ:MYL) announced today the U.S. launch of its rivastigmine transdermal drug-delivery patch, a generic version of Novartis‘ (NYSE:NVS) Exelon therapy. The company’s rivastigmine therapy is in... […]
-
Smart bandages trigger drug delivery to boost healing
on July 9, 2018 at 3:07 am
Researchers have developed a smart bandage which is able to monitor the status of a wound to deploy drugs effectively. A team of engineers from Tufts University revealed the prototype bandage last wee... […]
via Google News and Bing News
