Research led by Suresh Alahari, PhD, Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has demonstrated the potential of a protein to treat or prevent metabolic diseases including obesity and diabetes.
The findings are published online in the Journal of Biological Chemistry as a Paper in Press, available here. Nischarin is a novel protein discovered by the Alahari lab. The research team demonstrated that it functions as a molecular scaffold that holds and interacts with several protein partners in a number of biological processes. The lab’s earlier research found that Nischarin acts as a tumor suppressor that may inhibit the spread, or metastasis, of breast and other cancers.
“These studies demonstrate the potential of Nischarin as a regulator of metabolic diseases and suggest suppression of Nischarin function may be a valuable approach in the quest to cure such diseases as diabetes and obesity,” notes Dr. Alahari.According to the National Health and Nutrition Examination Survey (NHANES), 2013–2014, more than 2 in 3 US adults (70.2 percent) were considered to be overweight or obese. The American Diabetes Association says that in 2015, 30.3 million Americans, or 9.4% of the population, had diabetes.
The Latest on: Nischarin
Chancellor of Nunez Community College announces retirement, and other news of higher education
on September 3, 2017 at 11:45 pm
Tommy Warner, chancellor of Nunez Community College in Chalmette since 2000 ... Alahari's lab demonstrated that the novel protein Nischarin functions as a molecular scaffold that holds and interacts with several protein partners in a number of biological ... […]
Discovery may be key to obesity, diabetes Rx
on August 31, 2017 at 11:44 am
The findings are published online in the Journal of Biological Chemistry as a Paper in Press, available here. Nischarin is a novel protein discovered by the Alahari lab. The research team demonstrated that it functions as a molecular scaffold that holds ... […]
New protein may suppress breast cancer growth
on September 13, 2011 at 5:00 pm
Building upon Dr. Alahari's earlier discovery of Nischarin, a novel protein that regulates breast cancer cell migration and movement, this current study examines the presence and levels of Nischarin in breast cancer tumor tissue from 300 women as well as ... […]
The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity
on September 24, 2006 at 5:00 pm
Correspondence: Dr M Thullberg, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 141 57, Sweden. E-mail: [email protected] p21-activated kinase 1 (PAK1) is a mediator of downstream signaling from the small GTPases Rac and Cdc42 ... […]
IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells
on August 1, 2003 at 5:00 am
Correspondence: M Dontenwill, Pharmacologie et Physicochimie des Interactions Cellulaires et Moléculaires, UMR CNRS 7034, Faculté de Pharmacie, Université Louis Pasteur de Strasbourg, Illkirch, France. Tel: +33 3 90244267; Fax: +33 3 90244313; E-mail ... […]
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