Research led by Suresh Alahari, PhD, Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has demonstrated the potential of a protein to treat or prevent metabolic diseases including obesity and diabetes.
The findings are published online in the Journal of Biological Chemistry as a Paper in Press, available here. Nischarin is a novel protein discovered by the Alahari lab. The research team demonstrated that it functions as a molecular scaffold that holds and interacts with several protein partners in a number of biological processes. The lab’s earlier research found that Nischarin acts as a tumor suppressor that may inhibit the spread, or metastasis, of breast and other cancers.
“These studies demonstrate the potential of Nischarin as a regulator of metabolic diseases and suggest suppression of Nischarin function may be a valuable approach in the quest to cure such diseases as diabetes and obesity,” notes Dr. Alahari.According to the National Health and Nutrition Examination Survey (NHANES), 2013–2014, more than 2 in 3 US adults (70.2 percent) were considered to be overweight or obese. The American Diabetes Association says that in 2015, 30.3 million Americans, or 9.4% of the population, had diabetes.
The Latest on: Nischarin
- Dr. Robin McGoey on February 7, 2019 at 4:00 pm
Dr. Robin McGoey is a pathologist in New Orleans, Louisiana and is affiliated with West Jefferson Medical Center. She received her medical degree from Louisiana State University School of Medicine in ... […]
- Now, a novel research to advance cancer therapy on January 12, 2019 at 2:31 am
Dr. Alahari discovered the protein Nischarin, which is involved in a number of biological processes that include regulation of breast cancer cell migration and movement. Even though his lab has shown ... […]
- Research to advance cancer therapy on January 11, 2019 at 10:16 am
Dr. Alahari discovered the novel protein, Nischarin, which is involved in a number of biological processes including the regulation of breast cancer cell migration and movement. Although his lab has s... […]
- LSU Health New Orleans research could impact cancer therapy on January 11, 2019 at 10:00 am
Suresh Alahari, professor of biochemistry and molecular biology at LSU Health New Orleans School of Medicine, discovered the protein, Nischarin, which is involved in regulating breast cancer cell migr... […]
- Study suggests promising new Rx target for obesity and diabetes on December 17, 2018 at 9:34 am
The findings are published in the December 2018, issue of the International Journal of Obesity. "Nischarin disruption resulted in insulin resistance in female mice, but not in male mice, suggesting th... […]
- LSU researchers make discovery with potential to cure obesity, diabetes on September 12, 2017 at 7:13 pm
The discovery came as an accident when researchers were studying the gene, Nischarin, for its other benefits. Researchers said the gene acts as a tumor suppressor that may inhibit the spread, or metas... […]
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