Research led by Suresh Alahari, PhD, Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has demonstrated the potential of a protein to treat or prevent metabolic diseases including obesity and diabetes.
The findings are published online in the Journal of Biological Chemistry as a Paper in Press, available here. Nischarin is a novel protein discovered by the Alahari lab. The research team demonstrated that it functions as a molecular scaffold that holds and interacts with several protein partners in a number of biological processes. The lab’s earlier research found that Nischarin acts as a tumor suppressor that may inhibit the spread, or metastasis, of breast and other cancers.
“These studies demonstrate the potential of Nischarin as a regulator of metabolic diseases and suggest suppression of Nischarin function may be a valuable approach in the quest to cure such diseases as diabetes and obesity,” notes Dr. Alahari.According to the National Health and Nutrition Examination Survey (NHANES), 2013–2014, more than 2 in 3 US adults (70.2 percent) were considered to be overweight or obese. The American Diabetes Association says that in 2015, 30.3 million Americans, or 9.4% of the population, had diabetes.
The Latest on: Nischarin
- LSU researchers make discovery with potential to cure obesity, diabetes on September 13, 2017 at 2:15 pm
The discovery came as an accident when researchers were studying the gene, Nischarin, for its other benefits. Researchers said the gene acts as a tumor suppressor that may inhibit the spread, or metas... […]
- Discovery may be key to obesity, diabetes Rx on August 31, 2017 at 11:44 am
The findings are published online in the Journal of Biological Chemistry as a Paper in Press, available here. Nischarin is a novel protein discovered by the Alahari lab. The research team demonstrated ... […]
- New protein may suppress breast cancer growth on September 13, 2011 at 5:00 pm
Building upon Dr. Alahari's earlier discovery of Nischarin, a novel protein that regulates breast cancer cell migration and movement, this current study examines the presence and levels of Nischarin i... […]
- The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity on September 24, 2006 at 5:00 pm
Correspondence: Dr M Thullberg, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 141 57, Sweden. E-mail: [email protected] p21-activated kinase 1 (PAK1) is a mediator of do... […]
- IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells on August 1, 2003 at 5:00 am
Correspondence: M Dontenwill, Pharmacologie et Physicochimie des Interactions Cellulaires et Moléculaires, UMR CNRS 7034, Faculté de Pharmacie, Université Louis Pasteur de Strasbourg, Illkirch, France ... […]
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