Study also identified possible target for novel therapies
Age-related memory loss may be reversed by boosting blood levels of osteocalcin, a hormone produced by bone cells, according to mouse studies led by Columbia University Medical Center (CUMC) researchers. The research team also identified a receptor for osteocalcin in the brain, paving the way for a novel approach to treating age-related cognitive decline.
The paper was published today in the online edition of the Journal of Experimental Medicine.
“In previous studies, we found that osteocalcin plays multiple roles in the body, including a role in memory,” said study leader Gerard Karsenty, MD, PhD, the Paul A. Marks Professor and Chair, Department of Genetics & Development, and professor of medicine at Columbia. “We also observed that the hormone declines precipitously in humans during early adulthood. That raised an important question: Could memory loss be reversed by restoring this hormone back to youthful levels? The answer, at least in mice, is yes, suggesting that we’ve opened a new avenue of research into the regulation of behavior by peripheral hormones.”
Dr. Karsenty’s group, in collaboration with the laboratory of Eric Kandel, MD, University Professor and Kavli Professor of Brain Science at Columbia University and a key contributor to this study, conducted several experiments to evaluate osteocalcin’s role in age-related memory loss. In one experiment, aged mice were given continuous infusions of osteocalcin over a two-month period. The infusions greatly improved the animals’ performance on two different memory tests, reaching levels seen only in young mice.
The same improvements were seen when blood plasma from young mice, which is rich in osteocalcin, was injected into aged mice. In contrast, there was no memory improvement when plasma from young, osteocalcin-deficient mice was given to aged mice. But adding osteocalcin to this plasma before injecting it into the aged mice resulted in memory improvement. The researchers also used anti-osteocalcin antibodies to deplete the hormone from the plasma of young mice, reducing their performance on memory tests.
The researchers then determined that osteocalcin binds to a receptor called Gpr158 that is abundant in neurons of the CA3 region of the hippocampus, the brain’s memory center. This was confirmed by inactivating hippocampal Gpr158 in mice and subsequently giving them infusions of osteocalcin, which failed to improve their performance on memory tests.
The researchers did not observe any toxic effects from giving the mice osteocalcin. “It’s a natural part of our body, so it should be safe,” said Dr. Karsenty. “But of course, we need to do more research to translate our findings into clinical use for humans.”
In previous research, Dr. Karsenty found that osteocalcin injections also rejuvenate the muscles of older mice, allowing them to match the running speeds and distances of young mice.
The Latest on: Age-related memory loss
- The secrets of the 'super agers'on September 5, 2019 at 4:45 pm
When faced with common age-related challenges, such as losing the ability to multi ... remaining socially engaged and compensating for hearing loss by wearing a hearing aid. One aspect of this was ...
- Can Hearing Aids Prevent Memory Problems?on September 4, 2019 at 9:25 pm
A lot of prior research has found that hearing loss is connected with an increased risk of memory problems. In a 2018 analysis published in JAMA Otolaryngology–Head & Neck Surgery, researchers pooled ...
- 5 signs your pet is going through age-related cognitive changes — and what to do about iton September 4, 2019 at 8:05 am
“It involves memory, the ability to deal with a changing environment and interacting with other individuals,” Zanghi says. Just like people, pets go through age-related cognitive ... They have ...
- How not smoking, avoiding alcohol, exercising cut risk of memory loss by 34%on September 2, 2019 at 9:33 pm
Scientists say avoiding alcohol, cutting out cigarettes and exercising more may protect you from dementia (memory loss ... which have been linked to age-related diseases or inflammation.
- Visual short-term memory binding deficit with age-related hearing loss in cognitively normal older adultson August 29, 2019 at 2:37 am
Age-related hearing loss (ARHL) has been posited as a possible modifiable risk factor for neurocognitive impairment and dementia. Measures sensitive to early neurocognitive changes associated with ...
- DHEA and Testosterone for Cognitive Decline and Dementiaon August 28, 2019 at 3:48 pm
In this post I briefly review the evidence for DHEA as a treatment of age-related memory loss as well as Alzheimer’s disease. Inconsistent research findings Although DHEA is widely used to self-treat ...
- The Hidden Risks of Hearing Loss and How You Can Avoid Themon August 28, 2019 at 4:08 am
These processes include short- and long-term memory, learning ability ... deficient, or incompetent. Age-related hearing loss tends to be gradual, progressing from milder to greater impairment, and ...
- Best supplement for the brain: Taking this twice a day may boost your brain healthon August 28, 2019 at 2:36 am
age-related memory loss. The research, published in the American Journal of Geriatric Psychiatry, examined the effects of an easily absorbed curcumin supplement on memory performance in people without ...
- KAFASI: 'Where are my keys?' Is memory loss normal aging or sign of disease?on August 26, 2019 at 1:44 pm
So when he tells us, “Sometimes you will never know the value of a moment, until it becomes a memory,” we are inclined to pause ... there are at least 5 million people currently living with ...
- Low Dose Marijuana May Reverse Brain Agingon August 25, 2019 at 1:43 pm
Animal studies have shown marijuana to reverse aging processes in mice brains; older mice displaying memory loss and other age-related brain problems were given low doses of THC, treated mice were ...
via Google News and Bing News