RMIT scientists in Melbourne have led an international collaboration that potentially unlocks better treatment of viral diseases, including the flu and common cold.
The results were published in the prestigious scientific and medical journal Nature Communications.
Each year the flu virus sends 13,500 Australians to hospital and causes more than 3000 deaths among those aged over 50. The global burden is also staggering, with more than 5 million cases of infection annually with up to 10 per cent resulting in death.
The RMIT senior authors, Dr Stavros Selemidis (ARC Future Fellow) and Dr Eunice To (first author), collaborated with Professor Doug Brooks from University South Australia, Professor John O’Leary from Trinity College Dublin, Monash University’s Professor Christopher Porter, and other scientists and clinicians to investigate how viruses cause disease in humans.
The researchers discovered that a 1.5 billion-year-old cell biological process found in plants, fungi and mammals enhances viral disease in mice and highly likely also in humans. They identified a protein, Nox2 oxidase, that is activated by viruses, including influenza, rhinovirus (the common cold), dengue and HIV.
Once activated, Nox2 oxidase suppresses the body’s key antiviral reaction and its ability to fight and clear the viral infection, which in turn results in a stronger or more virulent disease in mice.
The study also investigated a new prototype drug to treat these debilitating viral diseases.
The researchers found that the Nox2 oxidase protein activated by the viruses is located in a cell compartment called endosomes. They carefully modified a chemical that inhibits or restrains the activity of Nox2 oxidase.
Their customised drug was found to be very effective at suppressing disease caused by influenza infection.
Selemidis, head of the Oxidant and Inflammation Biology Group within the Chronic Infectious and Inflammatory Diseases program at RMIT, said: “Current treatment strategies are limited as they specifically target circulating viruses and have either unknown or very little effect against new viruses that enter the human population.
“We have identified a protein of the immune system that contributes to the disease caused by flu viruses irrespective of their strain.
“We also developed a novel drug delivery system to target this protein, which drastically alleviated the burden of viral disease.
“The strength of this work is the multidisciplinary approach taken and the degree of collaboration. It includes researchers and clinicians from eight universities across Australia, the United States and Ireland.
“This work attracted considerable interest at the NADPH Oxidase GORDON conference in the USA last year.”
To said: “This work identifies a treatment strategy that has the potential to alleviate the symptoms caused by some of the most devastating viruses worldwide, including the flu.”
The Latest on: Viral diseases
- Researchers explore ability of Florida mosquitoes to transmit chikungunya virus on July 27, 2017 at 7:59 pm
University of Florida scientists are starting to better understand the ability of two Florida mosquito species to transmit two strains of chikungunya virus that have caused outbreaks of human disease around the world. The virus causes chikungunya fever ... […]
- Infectious disease expert on why British docs are suggesting you don’t need to finish your antibiotics course on July 27, 2017 at 1:12 pm
- Global Infectious Disease Testing Market Size, and Forecast 2022 - Mindray, Autobio, Kpsontech, Beckman Coulter, Abbott on July 27, 2017 at 1:07 pm
The Publication on global Infectious Disease Testing market has been itemized by research experts to discuss its growth, value, forecasts, and other critical aspects deemed significant for making a strong comeback or headway in the industry. The experts ... […]
- Case of Zika Virus, Likely Spread by Mosquito, Is Reported in Texas on July 27, 2017 at 9:11 am
The affected person, who was not identified, is no longer capable of transmitting the disease, officials said. The Zika virus usually disappears from the blood of recovering victims within two weeks, after which it can no longer be transferred by mosquitoes. […]
- Seasonal diseases, viral fevers on the rise in capital villages on July 27, 2017 at 8:43 am
THE HANS INDIA | Jul 27,2017 , 04:44 AM IST Seasonal diseases like malaria, dengue and viral fevers are increasing in the villages of capital.After taking over of lands by Capital Region Development Authority (CRDA) in the 29 villages under the land ... […]
- Asia Pacific Infectious Disease Diagnosis & Treatment Market is expected to Rise at a Remarkable CAGR 7.8% by 2023 on July 27, 2017 at 7:33 am
Market Research Future adds new report of “Infectious Disease Diagnosis & Treatment Market Research Report- Asia Pacific Forecast to 2023” it contains Company information, geographical data and Table of Content Infectious diseases are the diseases ... […]
- Explore Digital PCR and quantitative PCR market driven by increasing incidence of infectious diseases and genetic disorders on July 26, 2017 at 7:15 pm
Polymerase chain reaction (PCR) technology is used to amplify or make several copies of deoxyribonucleic acid (DNA) sequence of interest. Polymerase chain reaction (PCR) technology is used in various applications ranging from DNA cloning, diagnosis of ... […]
- Protecting newborns from infectious diseases on July 26, 2017 at 10:29 am
Last week, we reported on a newborn in Iowa who died days after being kissed. The baby contracted meningitis HSV1, which can be passed from someone with a cold sore. Since both her parents tested negative for the virus, doctors said the infant likely got ... […]
- There are diseases hidden in ice, and they are waking up on July 26, 2017 at 9:10 am
That means melting ice could potentially open a Pandora’s box of diseases. The temperature in the Arctic Circle is rising quickly, about three times faster than in the rest of the world. As the ice and permafrost melt, other infectious agents may be ... […]
- County to spray mosquitoes in Murrieta that can carry infectious diseases on July 25, 2017 at 12:36 pm
Spurred by residents’ complaints and a larger-than-normal number of mosquitoes in the area, county technicians will be spraying a 4-acre strip of lane in Murrieta early Wednesday, July 26. Crews will be using truck sprayers to target the mosquitoes ... […]
via Google News and Bing News