Approximately 80% of all sensory input is received via the eyes, so suffering from chronic retinal diseases that lead to blindness causes a significant decrease in the quality of life (QOL). And because retinal diseases are most common among the elderly, developing pathological analyses and treatments for retinal diseases has become an urgent issue in super-aging countries such as Japan.
Although evaluation of drug candidates against retinal diseases has been done on animal models, serious concerns arise regarding the ethics and costs in addition to the limitations of translating data from animal models to clinical settings.
In vitro cell culture models, an alternative to animal models, enable researchers to investigate specific molecules-of-interest and simply recapitulate complex and chronic conditions. Although studies on organ-on-a-chip for drug discovery have recently been extensively carried out, the organ-on-a-chip approach that targets the ocular tissues has been rarely investigated.
A joint research team from the Graduate Schools of Engineering and Medicine at Tohoku University has recapitulated a pathological condition of retinal diseases on a chip. They first cultured human retinal cells and vascular endothelial cells, mimicking the outermost structure of the retina.
When retinal cells were exposed to hypoglycemic and hypoxic conditions after the cells had grown up, endothelial cells were found to migrate to the side of retinal cells to damage them. This process partially recapitulates neovascularization in wet-type age-related macular degeneration (AMD).
Learn more: Reproducing a retinal disease on a chip
The Latest on: Retinal disease on a chip
- Retinal chip implant undergoes clinical trials on August 6, 2018 at 5:00 pm
After successful clinical trials in Germany, the chip is now being tested in Hong Kong and Britain before moving on to planned trials in the U.S. RP is a disease that mainly affects the retina – speci... […]
- Biotech Lung On A Chip Simulating Lung Disease on May 30, 2018 at 11:03 pm
Innovative new biotechnology could reduce cost and time of developing medicines to treat lung disease such as pulmonary fibrosis ... but instead of semiconducting materials the chip was placed on chip ... […]
- Lab-on-a-chip device mimics eye damage due to intense light on May 10, 2018 at 10:50 am
... they created a sophisticated retina cell network on a chip that is modeled after a human’s neural network. This will further the quest for finding the right drug to treat such retinal diseases. “M... […]
- Lab-on-a-chip device may help repair eye damage: study on May 10, 2018 at 5:31 am
... US created a sophisticated retina cell network on a chip that is modelled after a human's neural network. This will further the quest for finding the right drug to treat such retinal diseases, the... […]
- Scientists emulate the human blood-retinal barrier on a microfluidic chip on January 23, 2018 at 4:00 pm
These so-called "organ-on-chip" devices include microenvironments and microarchitectures that emulate living organs and tissues. Now, a team of scientists in Barcelona has developed a microfluidic dev... […]
- French Regulators Approve Human Trial of a Bionic Eye on October 26, 2017 at 1:29 pm
Five people with severe vision loss will have an experimental chip implanted in their eyes to help them ... which will be placed in people with an advanced type of retinal disease called dry age-relat... […]
- Reproducing a retinal disease on a chip on June 15, 2017 at 6:41 am
Approximately 80% of all sensory input is received via the eyes, so suffering from chronic retinal diseases that lead to blindness causes a significant decrease in the quality of life (QOL). And becau... […]
- A New Bionic Eye: Infrared Light-Powered Retina Implant Coming on April 28, 2015 at 6:09 am
The tiny chip sits behind the retina ... Those pulses are part of a chain reaction that sends information up the optic nerve to the brain. In certain retinal diseases, the photoreceptor cells die off, ... […]
- Farsighted engineer invents bionic eye to help the blind on March 22, 2013 at 3:10 pm
The Argus II Retinal Prosthesis System ... macular degeneration or other eye diseases that destroy the retina’s light-sensitive photoreceptors. At the heart of the device is a tiny yet powerful comput... […]
- New type of retinal prosthesis could better restore sight to blind, study says on May 12, 2012 at 5:00 pm
Unlike the regular video goggles, though, the images would be beamed from the LCD using laser pulses of near-infrared light to a photovoltaic silicon chip — one-third ... help people suffering from re... […]
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