Approximately 80% of all sensory input is received via the eyes, so suffering from chronic retinal diseases that lead to blindness causes a significant decrease in the quality of life (QOL). And because retinal diseases are most common among the elderly, developing pathological analyses and treatments for retinal diseases has become an urgent issue in super-aging countries such as Japan.
Although evaluation of drug candidates against retinal diseases has been done on animal models, serious concerns arise regarding the ethics and costs in addition to the limitations of translating data from animal models to clinical settings.
In vitro cell culture models, an alternative to animal models, enable researchers to investigate specific molecules-of-interest and simply recapitulate complex and chronic conditions. Although studies on organ-on-a-chip for drug discovery have recently been extensively carried out, the organ-on-a-chip approach that targets the ocular tissues has been rarely investigated.
A joint research team from the Graduate Schools of Engineering and Medicine at Tohoku University has recapitulated a pathological condition of retinal diseases on a chip. They first cultured human retinal cells and vascular endothelial cells, mimicking the outermost structure of the retina.
When retinal cells were exposed to hypoglycemic and hypoxic conditions after the cells had grown up, endothelial cells were found to migrate to the side of retinal cells to damage them. This process partially recapitulates neovascularization in wet-type age-related macular degeneration (AMD).
Learn more: Reproducing a retinal disease on a chip
The Latest on: Retinal disease on a chip
Lab-on-a-Chip Device Mimics Eye Damage Due to Intense Light
on May 8, 2018 at 5:00 pm
... they created a sophisticated retina cell network on a chip that is modeled after a human’s neural network. This will further the quest for finding the right drug to treat such retinal diseases. “M... […]
Scientists emulate the human blood-retinal barrier on a microfluidic chip
on January 23, 2018 at 4:00 pm
These so-called "organ-on-chip" devices include microenvironments and microarchitectures that emulate living organs and tissues. Now, a team of scientists in Barcelona has developed a microfluidic dev... […]
Reproducing a retinal disease on a chip
on June 15, 2017 at 6:41 am
Approximately 80% of all sensory input is received via the eyes, so suffering from chronic retinal diseases that lead to blindness causes a significant decrease in the quality of life (QOL). And becau... […]
A New Bionic Eye: Infrared Light-Powered Retina Implant Coming
on April 28, 2015 at 6:09 am
The tiny chip sits behind the retina ... Those pulses are part of a chain reaction that sends information up the optic nerve to the brain. In certain retinal diseases, the photoreceptor cells die off, ... […]
University Hospitals Eye Institute to Offer ‘First Bionic Eye’ Retinal Chip for Blind
on June 28, 2013 at 1:30 pm
“This is a remarkable breakthrough,” said Suber S. Huang, MD, MBA, Director, UH Eye Institute’s Center for Retina and Macular Disease, who also served as the Independent Medical Safety Monitor for cli... […]
Retinal implants that give sight to the blind show some success in trials
on February 21, 2013 at 12:58 pm
German-designed implants aimed at restoring vision to patients blinded by retinal disease have succeeded in the second phase of trials, researchers reported on Wednesday. The device was tested for up ... […]
Retinal implants clear new hurdle to reach second phase of trials
on February 20, 2013 at 3:55 pm
GERMAN-designed implants aimed at restoring vision to patients blinded by retinal disease have succeeded in the second phase ... The device consists of a tiny light-sensitive chip measuring 3mm by 3mm ... […]
Retinal Implant Restores Vision to the Blind Without a Camera
on February 20, 2013 at 9:10 am
In people with hereditary retinal diseases like retinitis pigmentosa, the eyes’ photoreceptors, or light sensors, degenerate slowly over time, eventually leading to blindness. While these people are u... […]
Solar-panel-like retinal prosthesis could better restore sight to blind
on May 12, 2012 at 5:00 pm
This pinpoint-sized photovoltaic chip ... the retina, scientists at the Stanford University School of Medicine have devised a system that may someday restore sight to people who have lost vision becau... […]
Will we ever restore sight to the blind?
on March 13, 2012 at 11:02 am
This miracle is thanks to a pioneering chip implanted in his retina ... of blindness called retinitis pigmentosa, an inherited disease that gradually destroys the light-detecting cells of the retina. ... […]
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