Approximately 80% of all sensory input is received via the eyes, so suffering from chronic retinal diseases that lead to blindness causes a significant decrease in the quality of life (QOL). And because retinal diseases are most common among the elderly, developing pathological analyses and treatments for retinal diseases has become an urgent issue in super-aging countries such as Japan.
Although evaluation of drug candidates against retinal diseases has been done on animal models, serious concerns arise regarding the ethics and costs in addition to the limitations of translating data from animal models to clinical settings.
In vitro cell culture models, an alternative to animal models, enable researchers to investigate specific molecules-of-interest and simply recapitulate complex and chronic conditions. Although studies on organ-on-a-chip for drug discovery have recently been extensively carried out, the organ-on-a-chip approach that targets the ocular tissues has been rarely investigated.
A joint research team from the Graduate Schools of Engineering and Medicine at Tohoku University has recapitulated a pathological condition of retinal diseases on a chip. They first cultured human retinal cells and vascular endothelial cells, mimicking the outermost structure of the retina.
When retinal cells were exposed to hypoglycemic and hypoxic conditions after the cells had grown up, endothelial cells were found to migrate to the side of retinal cells to damage them. This process partially recapitulates neovascularization in wet-type age-related macular degeneration (AMD).
Learn more: Reproducing a retinal disease on a chip
The Latest on: Retinal disease on a chip
New Lab-on-a-chip Device Mimics Eye Damage
on May 10, 2018 at 2:11 pm
... they created a sophisticated retina cell network on a chip that is modeled after a human's neural network. This will further the quest for finding the right drug to treat such retinal diseases. "Medical treatments have advanced but there is still no ... […]
Lab-on-a-chip device may help repair eye damage: study
on May 10, 2018 at 4:43 am
with other eye diseases will affect 196 million people worldwide in 2020. Researchers created a sophisticated retina cell network on a chip that is modelled after a humans neural network. (Photo: Pixabay) Scientists have developed a new lab-on-a-chip ... […]
Lab-on-a-chip device mimics eye damage due to intense light
on May 9, 2018 at 11:17 am
Credit: Houston Methodist Houston Methodist researchers developed a new lab-on-a-chip technology that could quickly screen possible drugs to repair damaged neuron and retinal connections ... drug to cure any one of these diseases. Our device can screen ... […]
Google Strikes Humble Tone While Promoting A.I. Technology
on May 8, 2018 at 5:02 pm
An artificial intelligence program running on Google’s so-called machine-learning software that helps diagnose eye disease from a retina image found that the ... Google said it would roll out a new processing chip to power many of its machine-learning ... […]
Lab-on-a-Chip Device Mimics Eye Damage Due to Intense Light
on May 8, 2018 at 5:00 pm
... they created a sophisticated retina cell network on a chip that is modeled after a human’s neural network. This will further the quest for finding the right drug to treat such retinal diseases. “Medical treatments have advanced but there is still ... […]
French Regulators Approve Human Trial of a Bionic Eye
on October 27, 2017 at 1:30 am
Five people with severe vision loss will have an experimental chip implanted in their eyes to help them ... which will be placed in people with an advanced type of retinal disease called dry age-related macular degeneration, or dry AMD. […]
Reproducing a retinal disease on a chip
on June 15, 2017 at 6:41 am
Approximately 80% of all sensory input is received via the eyes, so suffering from chronic retinal diseases that lead to blindness causes a significant decrease in the quality of life (QOL). And because retinal diseases are most common among the elderly ... […]
Solar-panel-like retinal prosthesis could better restore sight to blind
on May 12, 2012 at 5:00 pm
This pinpoint-sized photovoltaic chip ... the retina, scientists at the Stanford University School of Medicine have devised a system that may someday restore sight to people who have lost vision because of certain types of degenerative eye diseases. […]
Silicon Chip Takes Aim At Eye Disease
on January 1, 2001 at 3:59 am
The Optobionics chip is one of a handful of technologies being pursued by researchers to treat retinal diseases--the leading cause of untreatable blindness. Worldwide, 30 million people suffer from retinal disorders, including retinitis pigmentosa and age ... […]
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