Potential for regenerative medicine and cancer research earns doctoral student Ido Sagi a Kaye Innovation Award
Stem cell research holds huge potential for medicine and human health. In particular, human embryonic stem cells (ESCs), with their ability to turn into any cell in the human body, are essential to the future prevention and treatment of disease.
One set or two? Diploid versus haploid cells
Most of the cells in our body are diploid, which means they carry two sets of chromosomes — one from each parent. Until now, scientists have only succeeded in creating haploid embryonic stem cells — which contain a single set of chromosomes — in non-human mammals such as mice, rats and monkeys. However, scientists have long sought to isolate and replicate these haploid ESCs in humans, which would allow them to work with one set of human chromosomes as opposed to a mixture from both parents.
This milestone was finally reached when Ido Sagi, working as a PhD student at the Hebrew University of Jerusalem’s Azrieli Center for Stem Cells and Genetic Research, led research that yielded the first successful isolation and maintenance of haploid embryonic stem cells in humans. Unlike in mice, these haploid stem cells were able to differentiate into many other cell types, such as brain, heart and pancreas, while retaining a single set of chromosomes.
With Prof. Nissim Benvenisty, Director of the Azrieli Center, Sagi showed that this new human stem cell type will play an important role in human genetic and medical research. It will aid our understanding of human development – for example, why we reproduce sexually instead of from a single parent. It will make genetic screening easier and more precise, by allowing the examination of single sets of chromosomes. And it is already enabling the study of resistance to chemotherapy drugs, with implications for cancer therapy.
Diagnostic kits for personalized medicine
Based on this research, Yissum, the Technology Transfer arm of the Hebrew University, launched the company New Stem, which is developing a diagnostic kit for predicting resistance to chemotherapy treatments. By amassing a broad library of human pluripotent stem cells with different mutations and genetic makeups, NewStem plans to develop diagnostic kits for personalized medication and future therapeutic and reproductive products.
The Latest on: Haploid embryonic stem cells
Asterias Biotherapeutic: Spinal Injury Stem Cell Therapy Play
on April 18, 2018 at 5:59 am
It is important to note that the majority of stem cell therapies being investigated today use MSCs, NSCs, hCNS-SCs which are not embryonic stem cells. Asterias Biotherapeutics (AST) has a stem cell therapy (AST-OPC1) that uses pluripotent embryonic stem cells. […]
Breakthrough microscope revolutionizes live cell imaging of stem cells
on April 18, 2018 at 4:55 am
With sensitive cell lines, such as mammalian embryonic stem cells, there are simply no proper long-term movies produced yet. A Swiss company, Nanolive, developed a new revolutionary microscope, the 3D Cell Explorer, that for the first time allows ... […]
Cultivating Cartilage from Human Stem Cells
on April 18, 2018 at 12:59 am
‘By forcing certain molecular events occurring during the embryonic development of cartilage it is possible to generate stable cartilage tissue from adult human mesenchymal stem cells.’ Inhibiting signaling pathways Prof. Dr. Ivan Martin's research ... […]
Cultivating cartilage from stem cells
on April 17, 2018 at 11:14 am
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers now report. Stable joint cartilage can ... […]
First ‘haploid’ human stem cells could advance medical research
on July 15, 2017 at 10:04 pm
Most of the cells in our body are diploid, meaning that they carry two sets of chromosomes, one from each parent. Until now, scientists have succeeded in creating only haploid embryonic stem cells – containing a single set of chromosomes – in non-human ... […]
Hebrew U Isolates ‘Haploid’ Human Stem Cells, Changing Future of Medicine
on June 29, 2017 at 3:49 pm
Most of the cells in our body are diploid, which means they carry two sets of chromosomes — one from each parent. Until now, scientists have only succeeded in creating haploid embryonic stem cells — which contain a single set of chromosomes — in non ... […]
First 'haploid' human stem cells could change the face of medical research
on June 28, 2017 at 5:17 am
Haploid human embryonic stem cells. Credit: Azrieli Center for Stem Cells and Genetic Research at Hebrew University Stem cell research holds huge potential for medicine and human health. In particular, human embryonic stem cells (ESCs), with their ability ... […]
Parthenogenetic haploid embryonic stem cells produce fertile mice
on March 6, 2014 at 1:54 pm
Haifeng Wan, Zhengquan He, Mingzhu Dong, Tiantian Gu, Guan-Zheng Luo, Fei Teng, Baolong Xia, Wei Li, Chunjing Feng, Xin Li, Tianda Li, Ling Shuai, Rui Fu, Liu Wang, Xiu-Jie Wang, Xiao-Yang Zhao and Qi Zhou […]
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes
on October 12, 2013 at 11:21 pm
Hui Yang, Zhen Liu, Yu Ma, Cuiqing Zhong, Qi Yin, Chikai Zhou, Linyu Shi, Yijun Cai, Hanzhi Zhao, Hui Wang, Fan Tang, Yan Wang, Chenchen Zhang, Xin-yuan Liu, Dongmei Lai, Ying Jin, Qiang Sun and Jinsong L […]
From embryonic stem cells, a sperm replacement and easier path to genetic modification
on April 25, 2012 at 5:00 pm
... in the April 27 issue of the journal Cell have devised a new and improved method for producing genetically modified animals for use in scientific research. The method relies on haploid embryonic stem cells (haESCs) instead of sperm to artificially ... […]
via Google News and Bing News