via Nature
The number of drug-resistant tuberculosis (TB) cases is rising globally. But a newly discovered natural antibiotic — produced by bacteria from the lung infection in a cystic fibrosis patient — could help fight these infections.
Lab testing reported in the Journal of the American Chemical Society shows that the compound is active against multi-drug resistant strains.
Starting with the famous first discovery of penicillin from mold, scientists have continued to search for natural sources of antibiotics. And as pathogens develop resistance to once-reliable medicines, the search has taken on a new urgency. By 2040, more than a third of all TB cases in Russia, for example, could show resistance to first-line drugs currently used to fight the disease, a recent report published in Lancet estimates. Among potential new drug sources are species of the bacterial genus Burkholderia that thrive in a wide range of habitats, from soil to the human lung. One way these microbes have adapted to these diverse environments is by making potent antibiotics to take out their competition. In light of the growing threat of drug-resistant bacteria, particularly among TB strains, Gregory L. Challis, Eshwar Mahenthiralingam and colleagues wanted to see if Burkholderia might produce a promising anti-TB compound.
The researchers discovered that one species, Burkholderia gladioli, which was isolated from the sputum of a child with cystic fibrosis, produces an antibiotic called gladiolin. The compound belongs to the same structural class as etnangien, another antibiotic that has been investigated for its ability to jam bacterial cell machinery. But etnangien is highly unstable. The researchers found that gladiolin is much more stable than etnangien, and could therefore potentially be a better drug candidate. Lab testing also showed that gladiolin blocked the growth of four drug-resistant TB strains.
Learn more: Bacteria from cystic fibrosis patient could help thwart antibiotic-resistant TB
The Latest on: Antibiotic-resistant TB
Vitamin D helps treat lethal drug-resistant TB - Science Daily
February 6, 2019 - Vitamin D helps treat lethal drug-resistant TB Science DailyVitamin D has been found to speed up the clearance of tuberculosis (TB) bacteria from the lungs of people with multi-drug resistant TB, according to a study of ...
Drug-resistant TB cured with new approaches in post-war DRC - Medical Xpress
February 13, 2019 - Drug-resistant TB cured with new approaches in post-war DRC Medical XpressA high proportion of multidrug-resistant tuberculosis (TB) cases can be cured in conflict-affected communities with molecular diagnostics, shorter treatment ...
As patients challenge patent, J&J commits to tackling drug-resistant TB - BusinessLine
February 17, 2019 - As patients challenge patent, J&J commits to tackling drug-resistant TB BusinessLineWhile Bedaquiline patent is contested, firm denies its monopoly would get extended.
Deadly drug-resistant TB a 'blinking red' global threat: non-profit group - CTV News
February 8, 2019 - Deadly drug-resistant TB a 'blinking red' global threat: non-profit group CTV NewsDeadly, drug-resistant tuberculosis -- as lethal as Ebola and tough to treat in even the best hospitals -- is a "blinking red" worldwide threat, the head of a global ...
Physicists develop a new method to identify antibiotic-resistant bacteria - Phys.Org
February 13, 2019 - Physicists develop a new method to identify antibiotic-resistant bacteria Phys.OrgA team of physicists from Immanuel Kant Baltic State University have suggested a method to identify single antibiotic-resistant tuberculosis-causing bacteria.
IIT-Bombay study gives hope to resistant-TB patients - Times of India
February 13, 2019 - IIT-Bombay study gives hope to resistant-TB patients Times of IndiaIn what can bring hope for drug-resistant TB patients, a study conducted by IIT-Bombay has shown that an anti-TB drug - rifampicin - used in combinati.
Vitamin D may help treat lethal drug-resistant TB - Daily Excelsior
February 7, 2019 - Vitamin D may help treat lethal drug-resistant TB Daily ExcelsiorLONDON, Feb 7: Taking vitamin D supplements with antibiotics can help speed up the process of clearing multi-drug resistant tuberculosis bacteria from the.
Vitamin D Helps Body Clear TB Bugs: Study - http://www.newsgram.com/
February 9, 2019 - Vitamin D Helps Body Clear TB Bugs: Study http://www.newsgram.com/The immune system could be given a boost by adding Vitamin D to antibiotic treatment to help the body clear TB bugs, rather than relying on antibiotics.Study shows success in MDR-TB treatment | Cape Times - Independent Online
February 18, 2019 - Study shows success in MDR-TB treatment | Cape Times Independent OnlineCape Town – Researchers have reported success in treating multidrug-resistant tuberculosis (MDR-TB) in post-conflict parts of the Democratic Republic of ...Vitamin D helps combat drug-resistant TB - The Sentinel Assam
February 8, 2019 - Vitamin D helps combat drug-resistant TB The Sentinel AssamVitamin D, commonly known as the “sunshine vitamin”, can combat tuberculosis (TB) bacteria found in the lungs of people with multi-drug resistant TB.
- New Method to Identify Antibiotic-resistant Bacteria on February 13, 2019 at 11:00 pm
A team of physicists from Immanuel Kant Baltic State University proposed a method to quickly recognize single antibiotic-resistant bacterial cells that are the agents of tuberculosis. The new method h... […]
- Physicists Develop New Method to Identify Antibiotic-Resistant Bacteria on February 13, 2019 at 2:00 pm
A team of physicists from Immanuel Kant Baltic State University have developed a method to quickly identify single antibiotic-resistant bacteria cells that are the agents of tuberculosis. The new meth... […]
- Method to identify antibiotic-resistant bacteria developed on February 13, 2019 at 9:03 am
Researchers have developed a novel method to quickly identify single antibiotic-resistant bacteria cells, which are agents of tuberculosis (TB). The new method -- called the Raman scattering spectrogr... […]
- Physicists develop new method to identify antibiotics-resistant bacteria on February 13, 2019 at 4:12 am
Washington D.C.: Physicists have now found a method to quickly identify single antibiotic-resistant bacteria cells that are the agents of tuberculosis. The new method helps find the bacteria and evalu... […]
- Vystar to Resume Production of Rx3000 UV Light Air Purifiers for Use in Hospitals, Healthcare Facilities on February 7, 2019 at 6:18 am
Inactivates pathogens that cause measles, the common cold, MRSA (staph), whooping cough, TB, pneumonia and other antibiotic-resistant and viral infections. WORCESTER, Mass., Feb. 07, 2019 (GLOBE ... […]
- Using CRISPR to fight antibiotic-resistant ‘superbugs’ on February 5, 2019 at 5:09 am
Numerous other examples include malaria and tuberculosis ... “The rapid rise of antibiotic-resistant pathogens is one of the foremost global health concerns of modern times. […]
- The Rise of Antibiotic-Resistant Bacteria on January 13, 2019 at 8:22 pm
Apart from Neisseria gonorrhoeae, there are at least 10 other bacterial species that have antibiotic-resistant strains, and these include Staphylococcus aureus (Staph infections), Escherichia coli (E. ... […]
- Scientists develop new treatment for antibiotic-resistant tuberculosis on January 9, 2019 at 12:38 pm
The Royal College of Surgeons in Ireland's Prof. Sally-Ann Cryan, co-lead scientist on the study(Credit: Maxwell Photography) Like so many other diseases, tuberculosis is becoming increasingly resista... […]
- The Tuberculosis That Afflicts Much Of The World Was Likely Spread By Europeans on October 19, 2018 at 11:41 am
They chose to study "lineage 4," the most widely dispersed type of TB internationally, investigating both how the lineage originally evolved and how antibiotic-resistant forms of the lineage have spre... […]
- Inexpensive TB test holds promise for low-income countries on September 27, 2018 at 8:00 am
“The diagnostic approach that is typically used in the field doesn’t tell you anything about drug susceptibility, and knowing that is key to effectively treating infections of antibiotic-resistant tub... […]
via Google News and Bing News