via Nature
The number of drug-resistant tuberculosis (TB) cases is rising globally. But a newly discovered natural antibiotic — produced by bacteria from the lung infection in a cystic fibrosis patient — could help fight these infections.
Lab testing reported in the Journal of the American Chemical Society shows that the compound is active against multi-drug resistant strains.
Starting with the famous first discovery of penicillin from mold, scientists have continued to search for natural sources of antibiotics. And as pathogens develop resistance to once-reliable medicines, the search has taken on a new urgency. By 2040, more than a third of all TB cases in Russia, for example, could show resistance to first-line drugs currently used to fight the disease, a recent report published in Lancet estimates. Among potential new drug sources are species of the bacterial genus Burkholderia that thrive in a wide range of habitats, from soil to the human lung. One way these microbes have adapted to these diverse environments is by making potent antibiotics to take out their competition. In light of the growing threat of drug-resistant bacteria, particularly among TB strains, Gregory L. Challis, Eshwar Mahenthiralingam and colleagues wanted to see if Burkholderia might produce a promising anti-TB compound.
The researchers discovered that one species, Burkholderia gladioli, which was isolated from the sputum of a child with cystic fibrosis, produces an antibiotic called gladiolin. The compound belongs to the same structural class as etnangien, another antibiotic that has been investigated for its ability to jam bacterial cell machinery. But etnangien is highly unstable. The researchers found that gladiolin is much more stable than etnangien, and could therefore potentially be a better drug candidate. Lab testing also showed that gladiolin blocked the growth of four drug-resistant TB strains.
Learn more: Bacteria from cystic fibrosis patient could help thwart antibiotic-resistant TB
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Plague of 'vampire horseflies' prompts warning of 'killer' infections
on July 12, 2018 at 4:12 pm
A plague of 'vampire horseflies' has prompted warnings that the UK faces an outbreak of antibiotic resistant infections ... bites and conditions like TB and Typhoid might kill." ANTRUK has called for ... […]
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A century-old cure may help ward off superbugs, the 'global climate change of health'
on June 30, 2018 at 11:53 am
It doesn’t help the profit imperative that antibiotic-resistant diseases, like drug-resistant tuberculosis, overwhelmingly impact poorer people in developing nations, who can’t afford expensive therap... […]
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The world is running out of antibiotics, WHO report confirms
on June 23, 2018 at 5:26 pm
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on June 23, 2017 at 5:06 am
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