The number of drug-resistant tuberculosis (TB) cases is rising globally. But a newly discovered natural antibiotic — produced by bacteria from the lung infection in a cystic fibrosis patient — could help fight these infections.
Lab testing reported in the Journal of the American Chemical Society shows that the compound is active against multi-drug resistant strains.
Starting with the famous first discovery of penicillin from mold, scientists have continued to search for natural sources of antibiotics. And as pathogens develop resistance to once-reliable medicines, the search has taken on a new urgency. By 2040, more than a third of all TB cases in Russia, for example, could show resistance to first-line drugs currently used to fight the disease, a recent report published in Lancet estimates. Among potential new drug sources are species of the bacterial genus Burkholderia that thrive in a wide range of habitats, from soil to the human lung. One way these microbes have adapted to these diverse environments is by making potent antibiotics to take out their competition. In light of the growing threat of drug-resistant bacteria, particularly among TB strains, Gregory L. Challis, Eshwar Mahenthiralingam and colleagues wanted to see if Burkholderia might produce a promising anti-TB compound.
The researchers discovered that one species, Burkholderia gladioli, which was isolated from the sputum of a child with cystic fibrosis, produces an antibiotic called gladiolin. The compound belongs to the same structural class as etnangien, another antibiotic that has been investigated for its ability to jam bacterial cell machinery. But etnangien is highly unstable. The researchers found that gladiolin is much more stable than etnangien, and could therefore potentially be a better drug candidate. Lab testing also showed that gladiolin blocked the growth of four drug-resistant TB strains.
The Latest on: Antibiotic-resistant TB
- Drug resistant superbugs kill over 153,000 Americans a year - nearly seven times the CDC's estimates, new study suggests on November 30, 2018 at 10:26 am
In 2010, antibiotic resistant infections didn't even make the top 10 leading ... Around 700,000 people already die yearly due to drug-resistant infections including tuberculosis (TB), HIV and malaria ... […]
- Newfoundland scientists find a new way to fight superbugs on November 25, 2018 at 6:52 am
A Newfoundland company is working to level the field in the fight against antibiotic-resistant bacteria that could render diseases like pneumonia, tuberculosis and strep throat untreatable. The World ... […]
- The Tuberculosis That Afflicts Much Of The World Was Likely Spread By Europeans on October 19, 2018 at 3:41 pm
They chose to study "lineage 4," the most widely dispersed type of TB internationally, investigating both how the lineage originally evolved and how antibiotic-resistant forms of the lineage have spre... […]
- Inexpensive TB test holds promise for low-income countries on September 27, 2018 at 8:00 am
“The diagnostic approach that is typically used in the field doesn’t tell you anything about drug susceptibility, and knowing that is key to effectively treating infections of antibiotic-resistant tub... […]
- Return of the White Death: TB could make our progressive, innovation-driven world unsustainable on May 21, 2018 at 2:42 am
Of all the diseases that decimated emerging cities, tuberculosis (TB) was the worst. ‘Decimation’ – the taking of one in 10 – is an understatement. TB accounted for a quarter of all deaths in European ... […]
- Isolation, collapsing lungs and spitting bans: three ways we used to treat TB, and still might on September 14, 2017 at 10:11 pm
It’s now believed this technique was effective because the TB bacteria require oxygen to survive, but the complications of such surgery could be disfiguring or even fatal. Thoracic surgery continues t... […]
- Bacteria from cystic fibrosis patient could help fight antibiotic-resistant TB on June 23, 2017 at 5:06 am
This photomicrograph reveals Mycobacterium tuberculosis bacteria using acid-fast Ziehl-Neelsen stain; Magnified 1000 X. The acid-fast stains depend on the ability of mycobacteria to retain dye when tr... […]
- Bacteria from cystic fibrosis patient could help thwart antibiotic-resistant TB on June 14, 2017 at 7:53 am
The number of drug-resistant tuberculosis (TB) cases is rising globally. But a newly discovered natural antibiotic—produced by bacteria from the lung infection in a cystic fibrosis patient—could help ... […]
via Google News and Bing News