University of Toronto and Baycrest Rotman Research Institute (RRI) scientists have discovered a potential brain imaging predictor for dementia, which illustrates that changes to the brain’s structure may occur years prior to a diagnosis, even before individuals notice their own memory problems.
The joint study, published in the Neurobiology of Aging on May 8, looked at older adults who are living in the Toronto community without assistance and who were unaware of any major memory problems, but scored below the normal benchmark on a dementia screening test.
Within these older adults, researchers also found evidence of less brain tissue in the same subregion of the brain where Alzheimer’s disease originates (the anterolateral entorhinal cortex located in the brain’s temporal lobe).
This U of T-Baycrest study is the first to measure this particular brain subregion in older adults who do not have a dementia diagnosis or memory problems that affect their day-to-day routine. It is also the first study to demonstrate that performance on the Montreal Cognitive Assessment (MoCA) dementia screening test is linked to the volume (size) of this subregion, along with other brain regions affected early in the course of Alzheimer’s disease.
“This work is an important first step in determining a procedure to identify older adults living independently at home without memory complaints who are at risk for dementia,” says Dr. Morgan Barense of U of T’s Department of Psychology and senior author on the study.
The team studied 40 adults between the ages of 59 and 81 who live independently (or with a spouse) at home. All participants were tested on the MoCA. Those scoring below 26 – a score that indicates a potential problem in memory and thinking skills and suggests further dementia screening is needed – were compared to those scoring 26 and above.
“The early detection of these at-risk individuals has the potential to facilitate drug developments or other therapeutic interventions for Alzheimer’s disease,” says Dr. Rosanna Olsen, first author on the study, RRI scientist and assistant professor in U of T’s Department of Psychology. “This research also adds to our basic understanding of aging and the early mechanisms of Alzheimer’s disease.” Scientists were able to reliably measure the volume of the anterolateral entorhinal cortex by using high-resolution brain scans that were collected for each participant.
The strongest volume differences were found in the exact regions of the brain in which Alzheimer’s disease originates. The researchers are planning a follow-up study to determine whether the individuals who demonstrated poor thinking and memory abilities and smaller brain volumes indeed go on to develop dementia.
“The MoCA is good at diagnosing mild cognitive impairment (MCI) (a condition that is likely to develop into Alzheimer’s) and we are seeing that it may identify MCI in people who are not aware of a decline in their memory and thinking skills,” said Dr. Barense.
Alzheimer’s disease is a devastating neurodegenerative illness with widespread personal, societal and economic consequences. Currently, 564,000 Canadians currently live with dementia and 1.1 million Canadians are affected by the disease, according to the Alzheimer Society of Canada. There are 25,000 new cases of dementia diagnosed every year in Canada and it costs $10.4 billion to care for those living with dementia.
“A key take-away from the study is that it highlights the utility of the MoCA test in identifying individuals who are at-risk for dementia,” said Dr. Olsen.
Adults who are 40+ and interested in testing their memory and attention prior to raising concerns with their doctor can consult Baycrest’s scientifically-validated, online brain health assessment tool, Cogniciti at www.cogniciti.com.
The Latest on: Early dementia
- Dementia clearly linked to chronic boozing: Study on February 21, 2018 at 11:11 pm
Researchers examining more than 57,000 cases of early-onset dementia in France found that well over half were either alcohol-related, or accompanied by an additional diagnosis of alcohol abuse. (Shutterstock/File) Chronic heavy drinking is a major risk ... […]
- Heavy drinking puts you at high risk for early dementia, warns study on February 21, 2018 at 10:19 pm
If you are drinking your troubles away, you soon may not be able to remember them at all. A nationwide French study has just shown chronic heavy drinking is an especially potent risk factor for developing dementia before the age of 65. And for those who ... […]
- Heavy drinking may be risk factor for early-onset dementia on February 21, 2018 at 9:50 pm
Heavy drinking may be a major risk factor for early-onset dementia, new research suggests. Scientists who looked at 57,000 cases of dementia diagnosed before the age of 65 found that 39 per cent could be attributed to alcohol-related brain damage. […]
- Congenital heart disease may up risk of early dementia on February 21, 2018 at 9:44 pm
People born with heart disease may be at a higher risk of early onset of dementia, finds a study involving over 10,000 participants. Congenital heart disease, the most common type of birth defect, involves a defect on the walls of the heart, the valves of ... […]
- Heavy Drinking Tied to Early-Onset Dementia in French Study on February 21, 2018 at 2:12 pm
Heavy drinking may be a major risk factor for all types of dementia, especially early-onset dementia. Note that the prevalence increased in patients with early-onset dementia: 38.9 of early-onset cases were associated with alcohol-related brain damage and ... […]
via Google News and Bing News