A system composed of two different types of nanoparticles can be used to accurately, sensitively and quickly detect viruses.
The earlier a viral infection is detected, the more effective the treatment. Currently available tests are accurate but require a long time and/or specialized personnel, which are not a given in many outbreak settings. To address this, a team of researchers from The Hong Kong Polytechnic University developed a biosensor that detects Ebola and avian influenza subtype H7 viruses.
The team prepared gold nanoparticles (AuNPs) carrying ‘probes’ derived from the viral sample being tested. They also tagged ‘upconversion nanoparticles’ (UCNPs), which emit green light when hit by a near infrared laser, with probes specific for influenza virus H7 or Ebola. If the sample contains one of the two viruses, the two types of nanoparticles interact, causing the green light emitted by the laser-targeted UCNPs to dim. This process takes place in a short period of time (two hours in the case of the influenza test) and is quantifiable.
The system has proven to be very specific: using viral samples on the AuNPs that were only slightly different from the UCNP viral-specific tags did not yield results. The researchers then anchored the nanoparticles on a nanoporous alumina platform instead of having the two components in liquid solution. This increased the sensitivity of the assay and enabled the detection of ‘femtomolar’ amounts of virus: equivalent to the lower limit of detection in tests currently used in clinical practice. This is a crucial level of sensitivity, especially in the case of Ebola where early treatment can save lives.
The team is now planning to test the device on various subtypes of influenza and then move on to the fabrication of a multi-target detection platform that can simultaneously detect various subtypes of influenza viruses. The system is still at the research and development stage, but the researchers think it may become available in two to three years.
Learn more: Using nanoparticles to detect deadly viruses
The Latest on: Virus detection
- New, Rapid and Inexpensive Test for Zika Virus Detection on August 17, 2017 at 6:18 am
Zika virus disease is a mosquito borne viral infection predominant in tropical and subtropical parts of the world. Currently available Zika detection tests take days with added necessity of cold storage and transport of blood. New study proposes a 15 ... […]
- Serverless, Real-time Malware Detection: BinaryAlert on August 17, 2017 at 12:20 am
BinaryAlert is an open-source serverless AWS pipeline where any file uploaded to an S3 bucket is immediately scanned with a configurable set of YARA rules. An alert will fire as soon as any match is found, giving an incident response team the ... […]
- New Swine Coronavirus Detection Kit Helps Strengthen Biosecurity on August 16, 2017 at 7:24 pm
The VetMAX PEDV/TGEV/SDCoV Kit is a multiplex real-time PCR kit designed to detect three swine coronaviruses simultaneously using feed or environmental samples: Porcine epidemic diarrhea virus (PEDV) Transmissible gastroenteritis virus (TGEV) Swine delta ... […]
- To Avoid Antivirus, Criminals Are Now Using PowerPoint Files to Drop Malware on August 16, 2017 at 12:17 am
Cybercriminals are exploiting a vulnerability in Microsoft Office that allows them to evade detection by antivirus software and deliver malware using PowerPoint. Tracked as CVE-2017-0199, the vulnerability was first discovered as a zero-day remote code ... […]
- 3 Best Antivirus For macOS – Performance And Detection Comparison on August 14, 2017 at 11:38 pm
Apple users never had to worry about malwares until now, due to the popularity of macOS and the lack of antivirus installed on macOS laptops, hackers saw an opportunity in stealing credit card numbers, personal data and more when they can easily infect ... […]
via Google News and Bing News