Thousands of new immune system signals have been uncovered with potential implications for immunotherapy, autoimmune diseases and vaccine development.
The researchers behind the finding say it is the biological equivalent of discovering a new continent.
It’s as if a geographer would tell you they had discovered a new continent, or an astronomer would say they had found a new planet in the solar system. And just as with those discoveries, we have a lot of exploring to do.
– Professor Michael Stumpf
Our cells regularly break down proteins from our own bodies and from foreign bodies, such as viruses and bacteria. Small fragments of these proteins, called epitopes, are displayed on the surface of the cells like little flags so that the immune system can scan them. If they are recognised as foreign, the immune system will destroy the cell to prevent the spread of infection.
In a new study, researchers have discovered that around one third of all the epitopes displayed for scanning by the immune system are a type known as ‘spliced’ epitopes.
These spliced epitopes were thought to be rare, but the scientists have now identified thousands of them by developing a new method that allowed them to map the surface of cells and identify a myriad of previously unknown epitopes.
The findings should help scientists to better understand the immune system, including autoimmune diseases, as well as provide potential new targets for immunotherapy and vaccine design.
The research was led by Dr Juliane Liepe from Imperial College London and Dr Michele Mishto from Charité – Universitätsmedizin Berlin in Germany in collaboration with the LaJolla Institute for Allergy and Immunology and Utrecht University, and it is published today in Science.
Co-author of the study Professor Michael Stumpf from the Department of Life Sciences at Imperial said: “It’s as if a geographer would tell you they had discovered a new continent, or an astronomer would say they had found a new planet in the solar system.
“And just as with those discoveries, we have a lot of exploring to do. This could lead to not only a deeper understanding of how the immune system operates, but also suggests new avenues for therapies and drug and vaccine development.”
Prior to the new study, scientists thought that the machinery in a cell created signalling peptides by cutting fragments out of proteins in sequence, and displaying these in order on the surface of the cell.
However, this cell machinery can also create ‘spliced’ peptides by cutting two fragments from different positions in the protein and then sticking them together out of order, creating a new sequence.
Scientists knew about the existence of the spliced epitopes, but they were thought to be rare. The new study suggests that spliced epitopes actually make up a large proportion of signalling epitopes: they make up around a quarter of the overall number of epitopes, and account for 30-40 per cent of the diversity – the number of different kinds of epitopes.
PROS AND CONS
These extra epitopes give the immune system more to scan, and more possibilities of detecting disease. However, as the spliced epitopes are mixed sequences, they also have the potential to overlap with the sequences of healthy signallers and be misidentified as harmful.
This could help scientists understand autoimmune diseases, where the immune system turns against normal body tissues, such as in Type 1 diabetes and multiple sclerosis.
The study’s lead author, Dr Juliane Liepe from the Department of Life Sciences at Imperial, said: “The discovery of the importance of spliced peptides could present pros and cons when researching the immune system.
“For example, the discovery could influence new immunotherapies and vaccines by providing new target epitopes for boosting the immune system, but it also means we need to screen for many more epitopes when designing personalised medicine approaches.”
The Latest on: Immune system
via Google News
The Latest on: Immune system
- Five tips for boosting your immune systemon September 7, 2019 at 5:33 pm
If parting really is sweet sorrow, someone should probably explain that to all my friends who posted on Facebook celebrating the end of the summer holidays. No more three-hour queues for a two-minute ...
- Tiny fat bubbles hold key to rebooting the immune system and calming disease processon September 7, 2019 at 11:52 am
People living with inflammatory autoimmune disease could benefit from an 'immune system reboot', and researchers have isolated specific cells to target. The University of Queensland's Professor ...
- Disrupting the gut microbiome may affect some immune responses to flu vaccinationon September 6, 2019 at 4:50 pm
The normal human gut microbiome is a flourishing community of microorganisms, some of which can affect the human immune system. Researchers have now found that oral antibiotics, which can kill gut ...
- Nanotech turns pro-tumor immune cells into cancer-killing triple agentson September 5, 2019 at 6:25 pm
and we haven’t seen any of the toxicities that could be associated with treatments that modulate the immune system throughout the body, such as checkpoint inhibitors,” he said. And unlike other ...
- Researcher studies differences in the immune systems of men and womenon September 5, 2019 at 9:55 am
Females are less susceptible to infection but are 10 times more likely than males to develop an autoimmune disorder, such as hypothyroidism or rheumatoid arthritis. The female immune system is "a ...
- Histologics Cervical Brush Biopsy Imparts Immune Responseon September 5, 2019 at 5:47 am
We realizenot all precursors advance because of the protection of a woman's immune system. This early microscopic observation of a robust immune response following frictional brush biopsy of the ...
- Arbovirus manipulation of plant immune systems to favor disease spreadon September 4, 2019 at 8:07 am
Arthropod-transmitted viruses, known as arboviruses, can cause pandemic diseases in humans, animals, and crops. The Zika virus and cassava geminivirus are two such arboviruses. These pathogens ...
- Pneumonia uses hydrogen peroxide to weaken the immune systemon September 2, 2019 at 11:17 pm
Pneumonia is a lung infection, filling up the alveoli with pus and fluid. At present, it’s the leading cause of death among children. The lung infection accounts for 15 percent of all deaths in ...
- Grant to fund Tulane research on men's, women's immune systemson September 1, 2019 at 6:32 am
NEW ORLEANS — (AP) — Scientists at Tulane University have been awarded a $1 million grant to learn more about the differences between the immune systems of men and women. Tulane says in a news release ...
via Bing News