Montreal researchers clear a major hurdle in the fight for longevity
Hearing loss, brittle bones, sagging skin, a deteriorating mind: these are just some of the issues associated with growing old. For millennia, humans have fought the process of aging using everything from fountains of youth to pricey face creams, all to no avail. But a group of Montreal-based researchers is coming ever closer to achieving healthy longevity — armed with the power of science.
In a study recently published in Oncotarget, researchers from Concordia University and Idunn Technologies assess how six previously identified plant extracts can delay aging by affecting different signaling pathways that set the pace of growing old.
Vladimir Titorenko is a biology professor and the study’s senior author. He says that the potential of using these plant extracts for delaying the onset of age-related diseases is underscored by the fact that Health Canada classifies them as safe for human consumption. Five of them are recommended by the federal department as health-improving supplements with clinically proven benefits.
In the study, Titorenko and his co-authors confirmed that one extract is particularly effective: Salix alba, more commonly known as white willow bark, is the most potent aging-delaying pharmacological intervention yet described.
To make this identification, the researchers used yeast to test the effectiveness of the plant extracts. But why yeast? That’s because, at a cellular level, aging progresses similarly in yeast and humans. In both, the pace of aging is defined by a distinct set of chemical reactions arranged into several cascades. These cascades, which scientists call “signalling pathways,” regulate the rate of aging in a wide range of organisms.
Using yeast — the best cellular aging model — Titorenko and his colleagues monitored how the information flowing through each of these signalling pathways was affected by each of the six aging-delaying plant extracts.
“It’s known that some of these signalling pathways delay aging if activated in response to certain nutrients or hormones,” he says. “These pathways are called ‘anti-aging’ or ‘pro-longevity’ pathways. Other signalling pathways speed up aging if activated in response to certain other nutrients or hormones. These pathways are called ’pro-aging’ or ‘pro-death’ pathways.”
Co-author Éric Simard, CEO of Idunn Technologies, explains that each of the six aging-delaying plant extracts targets a different anti-aging or pro-aging signalling pathway.
It is especially noteworthy that this study revealed the following features of the six plant extracts as potential tools in decelerating chronic symptoms and diseases of old age:
- They imitate the aging-delaying effects of the caloric restriction diet in yeast
- They slow yeast aging by eliciting a mild stress response
- They extend yeast longevity more efficiently than any lifespan-prolonging chemical compound yet described
- They delay aging through signalling pathways implicated in age-related diseases
- One of them delays aging via a previously unknown pathway
- They extend longevity and delay the onset of age-related diseases in organisms other than yeast
“This study is an important step forward for science because these signaling pathways could eventually delay the onset and progression of chronic diseases associated with human aging,” says Simard, who has recently published a new book on the topic.
“These diseases include arthritis, diabetes, heart disease, kidney disease, liver dysfunction, stroke, neurodegenerative diseases like Parkinson’s, Alzheimer’s and Huntington’s diseases, and many forms of cancer.”
The Latest on: Delaying aging
via Google News
The Latest on: Delaying aging
- What will it take to replace the aging Portal Bridge? A major train disaster? | Kelly on December 14, 2018 at 11:50 am
That meant 80,000 passengers were delayed. Think of all the fans at MetLife Stadium being ... The story of delays for replacing the bridge is a window into a much larger problem of aging infrastructur... […]
- ‘Atlas,’ Next Game From Creators of ‘Ark,’ Delayed a Week on December 13, 2018 at 11:37 am
Player customization includes things like per-pixel tattoo designing, dynamic hair growth, and real-time aging systems. Make sure to check out our full interview for all of the detail built into ... […]
- Long time in the making: Aging Research Centre established at Grenfell Campus in Corner Brook on December 11, 2018 at 8:32 pm
The Aging Research Centre will be based at Grenfell with an auxiliary ... To Cake, who will sit on the centre’s management committee, it was a “no brainer.” The delay he said was perhaps because of mo... […]
- Your aging brain: Is it ‘use it or lose it’? on December 11, 2018 at 11:00 am
While the study’s recruits differed in their levels of ingoing intelligence, educational attainment and lifelong intellectual engagement, the researchers could measure and account for these factors to ... […]
- How to Achieve Healthy Aging While Reducing Your Risk of Diabetes on December 10, 2018 at 5:19 pm
it seems to have an aging-delaying effect, specifically in inhibiting cognitive decline and Alzheimer’s disease. (TAME)campbell Memory loss that occurs with aging can be made worse, he says, by the ef... […]
- Aging Research May Hold Key to New Alzheimer’s Treatments on December 10, 2018 at 5:53 am
“Targeting the common biological processes of aging may be an effective approach to developing therapies to prevent or delay age-related diseases, such as Alzheimer’s.&rdquo […]
- Speaking two languages may help the aging brain on December 8, 2018 at 9:00 am
Q: Can teaching children two languages delay or confuse their understanding ... And those areas of the brain overlap with the ones in which aging adult brains show decline or neurological pathological ... […]
- Mice Delayed Today's SpaceX Launch on December 5, 2018 at 10:00 am
The mission's one-day delay was due to a curiosity—moldy mouse food ... Rodent Research-8 (RR-8) "examines the physiology of aging and the effect of age on disease progression using groups of young an... […]
- Global Anti-Aging Products and Therapies Market 2018-2025 | Region Wise Analysis of Top Players - Allergan, Ipsen, Lanzhou Institute on December 5, 2018 at 2:25 am
rep_id=192628... Anti-Aging Products and Therapies is the product which delay, stop or retard the aging process. In our report we counted medical technique product which delay aging process. Unit mean... […]
via Bing News