During a heart attack, clots or narrowed arteries block blood flow, harming or killing cells within the tissue. But the damage doesn’t end after the crushing pain subsides. Instead, the heart’s walls thin out, the organ becomes enlarged, and scar tissue forms. If nothing is done, the patient can eventually experience heart failure. But scientists now report they have developed gels that, in animal tests, can be injected into the heart to shore up weakened areas and prevent heart failure.
The researchers will present their work today at the 252nd National Meeting & Exposition of the American Chemical Society (ACS). ACS, the world’s largest scientific society, is holding the meeting here through Thursday. It features more than 9,000 presentations on a wide range of science topics. A brand-new video on the research is available at http://bit.ly/ACShydrogels.
Heart attacks strike 750,000 people each year in the U.S., according to the American Heart Association. And more than 5 million U.S. residents are living with heart failure, with symptoms that progress from fatigue and shortness of breath to eventual death. “Heart failure is a huge problem, and few therapies are available for these patients,” says Jason A. Burdick, Ph.D., leader of the study.
Treatments include lifestyle changes, medication, implants or heart transplants. Burdick, who is at the University of Pennsylvania (Penn), explains that these options often don’t work well or, in the case of transplants, are hard to come by. So scientists are pursuing other treatment methods. For instance, researchers at other institutions have done animal studies in which they injected cells into the damaged section of the heart to try to repair damage. To prevent the cells from leaking out, those researchers embedded them in biodegradable “hydrogels” — water-swollen networks of polymer chains with a consistency similar to Jell-OTM. But the scientists noticed something odd when they ran control experiments in which they injected the hydrogel without added cells: Some of the animals’ hearts still showed improvement compared with untreated animals.
Based on those findings, a handful of labs are now experimenting with hydrogel treatments, including two materials that are in clinical trials. Neither is from Burdick’s lab, but as he notes, “It’s important we all keep moving forward to figure out how this therapy could be used, because it’s different than any current treatment.” In addition, different types of hydrogels could suit different patients’ needs.
Some experimental heart attack treatments require surgery to open up the chest, but the two hydrogel materials already in clinical trials are injected into the damaged tissue through a long catheter inserted through the skin — eliminating the need for open-chest surgery.
Burdick and his graduate student Christopher B. Rodell, in collaboration with Robert C. Gorman, M.D., also at Penn, are using this same minimally invasive technique in their own work. But his team has gone a step further by identifying properties that would be useful in treating heart attack patients and then designing hydrogels with those properties. For instance, his group developed a hydrogel that forms additional crosslinks between the polymer chains after injection. The resulting material is stiffer and lasts longer than a gel without these additional crosslinks and the gels in clinical trials.
In fact, Burdick’s gel is unique among hydrogels in providing mechanical support to stabilize the damaged area. In sheep studies, this gel limits formation of scar tissue, thinning of the heart’s walls and enlargement of the heart. By preserving the organ’s size, the gels also reduce leakage of blood through the mitral valve. Together, these benefits maintain the heart’s blood-pumping ability and could stave off heart failure.
The team’s materials are based on hyaluronic acid (HA), a type of sugar molecule that occurs naturally in the body. The researchers modified the HA molecules by attaching adamantane and cyclodextrin groups to allow the gels to flow through catheters, and they added thiol and methacrylate groups to enable post-injection cross-linking to stiffen the hydrogel. Once the researchers finalize the hydrogel formulation and delivery method, they hope to partner with a catheter firm to bring a product to market. Burdick’s team and other research groups are also designing hydrogels that contain drugs or cells that can repair heart tissue.
This research is being presented at a meeting of the American Chemical Society.
The Latest on: Injectable gels
via Google News
The Latest on: Injectable gels
- Injectable hydrogel lines up for multiple drug delivery on February 19, 2019 at 3:28 am
Top: the injectable hydrogel promptly recovers its stiffness after injection through a catheter; the centre panel shows the gel regaining its stiffness; on the right, the gel also sticks to the glass ... […]
- Viscosupplementation Market Development Trends & Competitive Analysis by Leading Industry Players on February 18, 2019 at 8:09 pm
Albany, NY -- (SBWIRE) -- 02/18/2019 -- Viscosupplementation is a minimally invasive procedure that involves injection of gel-like substances into a joint to assist the viscous properties of synovial ... […]
- 6 best energy gels on February 18, 2019 at 7:12 am
Another gel with a blend of carbs, Torq’s glucose and fructose mix provides a faster injection of energy than single carb options. There’s a small bump of electrolytes too to support hydration, though ... […]
- Male birth control gel trial comes to Nairobi on February 12, 2019 at 8:30 pm
The gel has been touted as the most promising new method of male birth control. Others that have previously been on trial have been the male pill and an injection. This is the second phase of a ... […]
- Male birth control gel trial starts in Kenya on February 12, 2019 at 1:57 pm
The gel has been touted as the most promising new method of male birth control. Others that have previously been on trial have been the male pill and an injection. This is the second phase of a trial ... […]
- Facial Injectable Market Size Will Grow at a Robust Pace Through 2028 on February 11, 2019 at 8:32 am
Development of advanced facial injectable with focus on stabilizing the main ingredients and cross linking with the gel medium so as to prolong the effect are the focus areas of the manufacturers. Inc... […]
- Injectable sponge-like gel enhances the quantity and quality of T-cells on February 11, 2019 at 8:02 am
The bone marrow cryogel three weeks after injection. The outside is covered with a bone shell and the inside of the sponge resembles vascularized bone marrow. Credit: Harvard University Bone ... […]
- Two women debate whether they would trust their man to use contraceptive gel daily on February 4, 2019 at 2:48 pm
Turns out a simple gel can stop unplanned pregnancies too ... it praised the breakthrough for being “more convenient” than men having “repeated injections”. And previous trials of the male contracepti... […]
- Kate Middleton Reportedly Swears by a $75 Natural Anti-Wrinkle Gel Called Biotulin on February 3, 2019 at 9:06 pm
According to a new report from The Sun, the Duchess of Cambridge's skincare product of choice is a natural anti-wrinkle gel Biotulin ... Unlike needle injections, it does not numb your face or restric... […]
- The Recombinant Human Interferon a2b Market in China (2018-2022): Injections, Capsules and Gels Take Up a Large Market Share - ResearchAndMarkets.com on January 21, 2019 at 5:24 am
DUBLIN--(BUSINESS WIRE)--The "Investigation Report on China's Recombinant Human Interferon a2b Market, 2018-2022" report has been added to ResearchAndMarkets.com's offering The report estimates that b... […]
via Bing News