The first steps towards developing a vaccine against an insidious sexual transmitted infection (STI) have been accomplished by researchers at McMaster University.
Researchers at the Michael G. DeGroote Institute for Infectious Disease Research at McMaster have developed the first widely protective vaccine against chlamydia, a common STI that is mostly asymptomatic but impacts 113 million people around the world each year and can result in infertility.
In a study, recently published in the journal Vaccine, the researchers show that a novel chlamydial antigen known as BD584 is a potential vaccine candidate for the most common species of chlamydia known as Chlamydia trachomatis.
As most C. trachomatis infections are asymptomatic, chlamydia can often go untreated and lead to upper genital tract infections, pelvic inflammatory disease, and infertility. This is why the promise of a vaccine would be extremely beneficial, says David Bulir, co-author of the study.
“Vaccine development efforts in the past three decades have been unproductive and there is no vaccine approved for use in humans,” said Bulir, who just finished his PhD in medical sciences at McMaster.
“Vaccination would be the best way to way to prevent a chlamydia infection, and this study has identified important new antigens which could be used as part of a vaccine to prevent or eliminate the damaging reproductive consequences of untreated infections.”
In the research team’s study, BD584 was able to reduce chlamydial shedding – a symptom of C. trachomatis – by 95 per cent. The antigen also decreased hydrosalpinx, another C. trachomatis symptom which involves fallopian tubes being blocked with serous fluids, by 87.5 per cent.
The results look very promising, said senior author James Mahony, a professor of Pathology and Molecular Medicine for McMaster’s Michael G. DeGroote School of Medicine and a researcher at St. Joseph Healthcare Hamilton’s Research Institute where the work was performed.
Co-author and McMaster PhD student, Steven Liang, explains, “not only is the vaccine effective, it also has the potential to be widely protective against all C. trachomatis strains, including those that cause trachoma.”
Trachoma is an eye infection caused by chlamydia and is the leading cause of preventable blindness affecting millions of people in many resource-poor regions of the world.
“The vaccine would be administered through the nose. This is easy and painless and does not require highly trained health professionals to administer, and that makes it an inexpensive solution for developing nations,” he said.
The next step is more testing for effectiveness against different strains of Chlamydia and in different formulations. The study was funded by the Canadian Institutes for Health Research.
The Latest on: Chlamydia
via Google News
The Latest on: Chlamydia
- Chlamydia is the most commonly reported STD in Ireland on February 19, 2019 at 2:03 am
Chlamydia is the most commonly reported sexually transmitted disease in Ireland, it has been revealed. And cases of the STD - which often has no symptoms - are on the rise. In 2017, there were a whopp... […]
- Sexually Transmitted Disease Rates Surge By 20-Plus Percent In Dallas County on February 18, 2019 at 10:23 am
Rates of sexually transmitted diseases – gonorrhea, syphilis and chlamydia in particular – are soaring in Dallas County. Cases of those three illnesses surged by more than 20 percent last year. The in... […]
- STD Rates Increase In Dallas County on February 18, 2019 at 7:27 am
Rates of sexually transmitted diseases – gonorrhea, syphilis and chlamydia in particular – have been increasing in Dallas County. That’s according to numbers from 2018 - the most recent figures. The i... […]
- 'After my chlamydia surprise I am now not ashamed to say I get tested regularly for STIs' on February 17, 2019 at 6:36 pm
I was 23 when I had my first STI test. I had been sexually active for five years, but never sought one; I had mostly always used protection and besides, I didn't have any symptoms. So it was a real sh... […]
- Chlamydia still remains Ireland's most dominant STD on February 17, 2019 at 6:30 pm
Chlamydia is the most commonly notified sexually transmitted disease in Ireland. There were 7,408 notifications of chlamydia in 2017 which was an 8pc increase in the number compared to 2016. The notif... […]
- NY has some of the highest rates of two STDs in the country, report says on February 16, 2019 at 12:55 pm
STATEN ISLAND, N.Y. -- New York has one of the highest rates of chlamydia and syphilis in the country, according to the National Council for Home Safety and Security (NCHSS). The NCHSS study, which br... […]
- La Crosse County gonorrhea cases on the rise, outpacing chlamydia on February 15, 2019 at 3:30 pm
Reportable cases of gonorrhea, a sexually transmitted disease, tripled in La Crosse county between 2017 and 2018, according to data from the Wisconsin Electronic Disease Surveillance System. […]
- Facts about Chlamydia on February 9, 2019 at 2:57 am
This new treatment can help you deal with Chlamydia. © Shutterstock This new treatment created in Ho’s lab targets chlamydia infection by preventing the majority of bacteria from entering cells in you... […]
- New Treatment for Chlamydia Infections on February 7, 2019 at 12:50 am
Prevention and treatment for chlamydia, the most commonly occurring sexually transmitted bacterial infection has been found. Unlike the traditional method of treating the disease with antibiotics, the ... […]
- Gene therapy against chlamydia to prevent infection shows promise on February 6, 2019 at 8:40 am
Feb. 6 (UPI) --The most common sexually transmitted disease in the world may have finally met its match, as researchers say they developed a treatment to prevent chlamydia. Researchers report in a stu... […]
via Bing News