Scientists believe they have discovered a way to “steer” the immune system to kill cancers.
Researchers at University College, London have developed a way of finding unique markings within a tumour – its “Achilles heel” – allowing the body to target the disease.
But the personalised method, reported in Science journal, would be expensive and has not yet been tried in patients.
Experts said the idea made sense but could be more complicated in reality.
However, the researchers, whose work was funded by Cancer Research UK, believe their discovery could form the backbone of new treatments and hope to test it in patients within two years.
They believe by analysing the DNA, they’ll be able to develop bespoke treatment.
People have tried to steer the immune system to kill tumours before, but cancer vaccines have largely flopped.
One explanation is that they are training the body’s own defences to go after the wrong target.
The problem is cancers are not made up of identical cells – they are a heavily mutated, genetic mess and samples at different sites within a tumour can look and behave very differently.
They grow a bit like a tree with core “trunk” mutations, but then mutations that branch off in all directions. It is known as cancer heterogeneity.
The international study developed a way of discovering the “trunk” mutations that change antigens – the proteins that stick out from the surface of cancer cells.
Professor Charles Swanton, from the UCL Cancer Institute, added: “This is exciting. Now we can prioritise and target tumour antigens that are present in every cell – the Achilles heel of these highly complex cancers.
The Latest on: Cancer research
via Google News
The Latest on: Cancer research
- Osaka University-centered study finds concerning trends in cervical cancer and treatment response on February 7, 2019 at 12:49 am
Japan may be showing how ignoring that knowledge could prove hazardous, as it is the only advanced economy in which the cervical cancer rate is increasing. New research adds further nuance to this sit... […]
- UCLA researcher awarded Sjöberg Prize for pioneering targeted breast cancer treatment on February 7, 2019 at 12:45 am
Dennis Slamon, director of the Revlon/UCLA Women’s Cancer Research Program, won the Sjöberg Prize from the Royal Swedish Academy of Sciences and Sweden’s Sjöberg Foundation. The prize aims ... […]
- NETRF announces $2.5 million funding for neuroendocrine cancer research on February 6, 2019 at 11:38 pm
The Neuroendocrine Tumor Research Foundation (NETRF) continues its aggressive funding of neuroendocrine cancer research with eight new grants totaling $2.5 million. With this newest round of funding, ... […]
- Cancer Researchers Say Trump's $500M Pledge Will Help But Is No Moonshot on February 6, 2019 at 11:31 pm
President Trump’s State of the Union proposal to set aside $500 million over the next 10 years to fund pediatric cancer research was cheered by experts in the field even though they said it’s not near... […]
- GenesisCare and the University of Oxford establish innovative 10-year cancer research partnership on February 6, 2019 at 11:17 pm
UK, 7 February 2019: Today GenesisCare and the University of Oxford's Department of Oncology announce the launch of an exclusive 10-year partnership to enhance access to the latest technology in medic... […]
- Standing O at State of the Union for Long Hill 10-Year Old Cancer Survivor Grace Eline, Trump Proposes $500 Million for Pediatric Cancer Research on February 6, 2019 at 6:11 pm
WARREN, NJ - President Donald Trump called 10-year old Grace Eline “an inspiration to everyone in this room” in his State of the Union address on Tuesday. And Eline received multiple standing ovations ... […]
- Northam, Fairfax skip basketball fundraiser for cancer research on February 6, 2019 at 5:59 pm
RICHMOND — Despite controversies around the Capitol, Virginia legislators and lobbyists met on the basketball court to raise money for cancer research, with two notable absences: Gov. Ralph Northam an... […]
- 'Power of Love' event in Hampton raises money for brain cancer research on February 6, 2019 at 12:00 pm
HAMPTON, Va. — The "Power of Love" event in Hampton raises money for brain cancer research — and it honors the memory of Malinda Brown. Malinda lost her battle to Glioblastoma multiforme and her husba... […]
- Trump Vows More for Cancer Research, Lower Drug Prices in State of the Union on February 6, 2019 at 9:48 am
Last night in his third State of the Union Address, President Donald J. Trump announced his plan to amp up the fight against childhood cancer. Sitting alongside First Lady Melania Trump was Grace Elin... […]
- Pelosi rips Trump's childhood cancer research boost as inadequate on February 6, 2019 at 9:45 am
House Speaker Nancy Pelosi on Wednesday trashed President Donald Trump’s plan to boost funding for childhood cancer research by $500 million over a decade, deriding his State of the Union proposal as ... […]
via Bing News