A new method for testing bacteria in wounds, published in Wound Repair and Regeneration, could lead to lower health care costs, minimize drug resistance, and improve patient outcomes
A new method for detection of infection in wounds could take physicians less than a minute to complete, rather than the current 24 hours it takes to plate bacteria and leave it to incubate overnight, according to research by the George Washington University’s (GW) Victoria Shanmugam, M.D.
Shanmugam and co-authors Edgar Goluch, Ph.D., DiPietro Assistant Professor of Chemical Engineering at Northeastern University College of Engineering, and Agnes Chan, Ph.D., assistant professor at the J. Craig Venter Institute, published this new method in the journal Wound Repair and Regeneration. The method uses an electrochemical detection strategy to identify molecules produced by the bacteriaPseudomonas, which commonly infects chronic wounds.
The team tested the use of an inexpensive, disposable electrochemical sensor that immediately reveals bacteria based on the detection of pyocyanin, a bacterial quorum sensing molecule produced by Pseudomonas. The probe correctly identified the presence of the bacterium 71 percent of the time and correctly identified absence of the bacterium 57 percent of the time.
“Being able to detect Pseudomonas and other infectious organisms at the time of the clinic visit will greatly enhance our ability to take care of patients,” said Shanmugam, director of the Division of Rheumatology at the GW School of Medicine and Health Sciences and principal investigator of the WE-HEAL study, a National Institutes of Health-funded study investigating the interplay of the host immune response and wound bed microbiome in patients with chronic wounds. “We would not have to wait for culture results before making a decision about antibiotics, and this would allow us to better tailor therapies for our patients.”
After further enhancement and testing, probes harnessing this methodology could potentially provide a way for physicians to detect wound infections at the bedside, allowing physicians to switch from broad-spectrum antibiotics to specific directed therapies sooner, lowering health care costs, minimizing drug resistance, and improving patient care outcomes.
“Infections are a major challenge in medicine, and by using this probe, we were able to harness one of the unique molecules produced by bacteria to detect infection,” said Shanmugam. “Through this ongoing collaboration with Dr. Goluch’s team of engineers, we plan to continue to refine this testing method and hope to scale it up for detection of other bacteria and to optimize it for clinical use.”
The Latest on: Wound infections
via Google News
The Latest on: Wound infections
- Outbreak of salmonella infections linked to pig ear dog treats expands to 35 stateson September 6, 2019 at 9:29 am
Symptoms of salmonella infection in humans include diarrhea ... licking humans’ faces after they eat or from licking open wounds. Pet food should also be stored away from human food to avoid ...
- Advanced Wound Care Market Future Scope, Demands and Projected Industry Growths to 2025on September 6, 2019 at 8:24 am
Treatment at home care further reduces the chances of hospital acquired infections. Owing to these advantages, homecare settings are poised to witness robust growth throughout the forecast period.
- 2019 Study: Hospital Acquired Infections Market to Expand Phenomenally...on September 6, 2019 at 12:28 am
respiratory infections and surgical wound infections. Such infections can develop in the nursing home, hospital, outpatient clinic, rehabilitation facility or any other clinical settings.
- Wound Care Devices Global Market Forecast To 2022on September 5, 2019 at 7:00 am
that produce wound care devices which prevent wound infections and promote wound healing.This industry includes establishments that produce traditional adhesive dressing and traditional gauze ...
- Dental Wound Dressings Market 2018 Industry Size | Growth Opportunities, Supply, Demand, Applications, Sales Analysis and Forecast to 2026on September 5, 2019 at 3:17 am
which is used in oral or maxillofacial surgery and dentoalveolar surgery to dress wounds, relieve pain, and prevent infection and to promote healing. Postoperative bleeding is major complication after ...
- Asia-Pacific Wound Care Product Market Global Industry Trends, Share, Size and Forecast Report By 2023on September 5, 2019 at 12:20 am
wound care products are becoming increasingly popular due to the surveillance of infections in wounds post-surgery. The Asia Pacific wound care product market is anticipated to expand at an overall ...
- ManilaMed launches their new Wound Care Uniton September 3, 2019 at 7:40 am
The deeper or dirtier a wound is, the more care it needs. Basic wound care can prevent infection and quickly heal the body’s process. However, there are also non-healing wounds that may not heal ...
- Antimicrobial action of autologous platelet-rich plasma on MRSA-infected skin wounds in dogson September 3, 2019 at 2:21 am
Unilateral circular full-thickness skin wounds were created then a MRSA suspension was injected locally. Treatment started at 1st week post infection with subcutaneous infiltration of autologous ...
- Researchers reveal how bacteria behind hospital infections block out antibioticson September 2, 2019 at 3:19 am
The bacterium Klebsiella pneumoniae causes infections in the lungs, blood and wounds of those in hospitals, and patients that have compromised immune systems are especially vulnerable. More than ...
- Man Imprisoned For Stapling Pet Dog's Wound, Ignoring Puncture Wound Of Anotheron August 30, 2019 at 9:14 am
The SPCA added that the animal doctor made it clear to the defendant that “there was an increased risk of infection” to Bella since the wound was made by a dog bite and that the dog needed antibiotics ...
via Bing News