Thermal ablation with magnetic resonance–guided focused ultrasound surgery (MRgFUS) is a noninvasive technique for treating fibroids and cancer. New research from UC Davis shows that combining the technique with chemotherapy can allow complete destruction of tumors in mice.
MRgFUS combines an ultrasound beam that heats and destroys tissue with a magnetic resonance imaging to guide the beam and monitor the effects of treatment. The effectiveness of the treatment can be limited by the need to spare normal tissue or critical structures on the tumor margins, as well as the need to eliminate micrometastases.
In a new paper in The Journal of Clinical Investigation, Katherine W. Ferrara, distinguished professor of biomedical engineering at UC Davis, and colleagues report on a strategy that can destroy an entire tumor without thermal destruction of the tumor margin. Her group demonstrated a dramatic increase in the concentration of anti-cancer chemotherapy within several types of MRgFUS thermal ablation-treated tumors.
“MRgFUS is already FDA approved for the treatment of uterine fibroids and palliation of bone metastases. We hope to expand the indication for MRgFUS by supplementing it with chemotherapy,” said first author Andrew Wong, a graduate student with the UC Davis Physician Scientist Training Program.
Ferrara’s previous research has shown that ultrasound-induced mild hyperthermia can enhance the accumulation of tiny nanoparticles carrying anti-cancer drugs, but the accumulation is dependent on the type of tumor. Her group hypothesized that combining thermal ablation and chemotherapy could improve efficacy across multiple types of tumors.
The team used a variety of techniques including combined positron emission tomography/computed tomography (PET-CT), magnetic resonance imaging, autoradiography, and fluorescence imaging to track nanoparticles loaded with the chemotherapy drug doxorubicin in a mouse model of breast cancer.
They found that as the ultrasound damaged the tumor and induced a local immune response, nanoparticles accumulated in the tumor and the local drug concentration increased 50-fold. The high drug concentrations continued over several weeks, increasing total exposure of the tumor to the drug.
Ferrara’s research team found that the enhanced drug accumulation induced by MRgFUS resulted in improved survival and a consistent cure in their preclinical model of breast cancer, even when part of the tumor was left intact.
They also demonstrated that an effective cure could be achieved with a carefully designed protocol involving heat-activated nanoparticles, which, when gently heated by ultrasound, release their chemotherapeutic payload in the vasculature surrounding the tumor.
The Latest on: MRgFUS
via Google News
The Latest on: MRgFUS
- MR-Guided Focused Ultrasound for the Novel and Innovative Management of Osteoarthritic Knee Pain on April 9, 2019 at 5:00 pm
MRgFUS treatment had a potential of rapid and long-lasting pain alleviation without adverse side effects. Significant increase of PPTs on treated area showed successful denervation effect on the ... […]
- Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study on January 22, 2019 at 4:00 pm
In animals, MR-guided focused ultrasound (MRgFUS) with intravenously injected microbubbles can temporarily and repeatedly disrupt the BBB in a targeted fashion, without open surgery. Our objective is ... […]
- ELBIT IMAGING LTD. ANNOUNCES THAT THE CMS HAS UPDATED THE REIMBURSMENT CODE FOR INSIGHTEC'S MRGFUS TREATMENTS on November 13, 2018 at 5:21 am
Tel Aviv, Israel, Nov. 13, 2018 (GLOBE NEWSWIRE) -- Elbit Imaging Ltd. (the “Company”) (TASE, NASDAQ: EMITF) announced today, further to its press release dated December 14, 2017, that the Centers for ... […]
- ELBIT IMAGING LTD. ANNOUNCES THAT THE CMS HAS UPDATED THE REIMBURSMENT CODE FOR INSIGHTEC'S MRGFUS TREATMENTS on November 12, 2018 at 10:00 pm
Elbit Imaging Ltd. (the "Company") (TASE, NASDAQ: EMITF) announced today, further to its press release dated December 14, 2017, that the Centers for Medicare and Medicaid Services (the "CMS") posted ... […]
- Battling Alzheimer's through Better Access to the Brain on November 1, 2018 at 5:00 pm
We have high hopes that the therapy, which uses a technique called magnetic resonance–guided focused ultrasound (MRgFUS), will one day help treat Alzheimer’s. We also think the technology will help ... […]
- INSIGHTEC Closes $150 Million Series E Financing on January 30, 2018 at 4:00 pm
INSIGHTEC, a commercial-stage medical technology company revolutionizing surgery with incisionless MRI-guided focused ultrasound (MRgFUS) announced today the closing of a $150 million Series E private ... […]
- INSIGHTEC's Exablate Neuro Named Best Medical Technology at Esteemed Prix Galien Awards 2017 on October 27, 2017 at 9:05 am
INSIGHTEC, the leader in MR-guided Focused Ultrasound (MRgFUS), has been awarded Best Medical Technology for Exablate Neuro by The Galien Foundation. Exablate Neuro is an innovative medical technology ... […]
- Magnetic Resonance-Guided Focused Ultrasound Versus Conventional Radiation Therapy for Painful Bone Metastasis: A Matched-Pair Study on September 20, 2017 at 2:16 pm
Background: Magnetic resonance-guided focused ultrasound (MRgFUS) is an alternative local therapy for patients with painful bone metastasis for whom standard conventional radiation therapy (RT) has ... […]
- Pennsylvania Neurosurgeons Perform First Focused Ultrasound Treatment for Essential Tremor on May 16, 2017 at 11:24 am
John Lukens became the first patient in Pennsylvania to receive MR-guided Focused Ultrasound Treatment (MRgFUS) for Essential Tremor (ET). At age 61, Lukens has suffered with bilateral Essential ... […]
- First essential tremor patient in Pennsylvania treated with MRgFUS symptom-free on May 16, 2017 at 6:45 am
Surgeons at Pennsylvania Hospital in Philadelphia became the first in the state to treat an essential tremor patient with MR-guided focused ultrasound on April 27. Two weeks after the procedure, the ... […]
via Bing News