An estimated seven to ten million people worldwide are living with Parkinson’s disease (PD), which is an incurable and progressive disease of the nervous system affecting movement and cognitive function. More than half of PD patients develop progressive disease showing signs of dementia similar to Alzheimer’s disease. A research team at University of Copenhagen, Denmark, has discovered that non-inheritable PD may be caused by functional changes in the immune regulating gene Interferon-beta (IFN?). Treatment with IFN?-gene therapy successfully prevented neuronal death and disease effects in an experimental model of PD. The results have just been published in prestigious scientific journal Cell.
Protein regulates waste management in nerve cells
The human brain consists of approximately 100 billion neurons, which coordinate activities in all parts of the body. At Biotech Research and Innovation Centre (BRIC), University of Copenhagen, the group of Professor Shohreh Issazadeh-Navikas has discovered that the immune gene IFN? plays a vital role in keeping neurons healthy.
-We found that IFN? is essential for neurons ability to recycle waste proteins. Without this, the waste proteins accumulate in disease-associated structures called Lewy bodies and with time the neurons die, explains assistant professor Patrick Ejlerskov, the first author of this report.
The research team found that mice missing IFN? developed Lewy bodies in parts of the brain, which control body movement and restoration of memory, and as a result they developed disease and clinical signs similar to patients with PD and dementia with Lewy bodies (DLB).
New understanding of non-familial Parkinson’s disease
While hereditary gene mutations have long been known to play a role in familial PD, the study from BRIC offers one of the first models for so-called non-familial PD, which comprises the majority (90-95%) of patients suffering from PD. According to professor Shohreh Issazadeh-Navikas the new knowledge opens new therapeutic possibilities:
–This is one of the first genes found to cause pathology and clinical features of non-familial PD and DLB, through accumulation of disease-causing proteins. It is independent of gene mutations known from familial PD and when we introduced IFN?-gene therapy, we could prevent neuronal death and disease development. Our hope is that this knowledge will enable development of more effective treatment of PD, says professor Shohreh Issazadeh-Navikas.
The Latest on: Parkinson’s
via Google News
The Latest on: Parkinson’s
Family step out to help to find a cure for Parkinsons
on May 22, 2019 at 9:55 am
A WOMAN from Ludlow is calling for Shropshire residents to unite and help them stop Parkinson’s for good by joining a sponsored evening walk for Parkinson’s event around Ludlow Castle. The Ludlow Walk ... […]
Mum died on operating table after being told broken leg was pulled hamstring
on May 19, 2019 at 8:21 am
Sarah-Jayne Roche before her marathon for Parkinsons UK, prompted by her father’s diagnosis with the illness (Picture: Media Wales) A mum-of-two died just days after a fractured femur was ... […]
Pedalling for Parkinsons
on May 17, 2019 at 11:12 am
PICTON — Another cycling event will be taking advantage of Prince Edward County’s natural beauty this summer. The husband and wife team of Jim Redmond and Krista Simonett appeared before Prince Edward ... […]
Caregiver Support Group to host public meeting in St. Charles
on May 16, 2019 at 3:31 am
Family members or friends who are caring for individuals with Parkinsons, dementia or any other chronic illness are invited to attend the Caregiver Support Group meeting on from 7 to 8 p.m. May 21 at ... […]
Not just a tremor: 10 early symptoms of Parkinson's disease you should know about
on May 14, 2019 at 5:00 pm
However, as Parkinson's UK (parkinsons.org.uk) points out, it's not just tremors you need to be on the lookout for. The condition can actually affect people in a wide range of ways – in fact, there ... […]
Parkinsons Disease Drugs And Therapeutics Market Size, key Manufacturers, Application, Type, End-user, Forecast to 2028
on May 2, 2019 at 2:53 am
May 02, 2019 (WiredRelease via COMTEX) -- Parkinson’s disease is a chronic and progressive neurological disorder where the symptoms continue and worsen with time. The primary symptoms include tremor, ... […]
Manhattan cyclist rides in honor of his father, to bring awareness to Parkinsons
on April 18, 2019 at 5:00 pm
TOPEKA (WIBW) --Matthew Schindler is a man on a mission. A mission that requires rolling around Kansas on two wheels. Schindler is riding through Kansas during this Parkinsons Awareness Month, to ... […]
Grandfather with Parkinson's finds student who came to his aid on train
on April 11, 2019 at 11:30 am
The medical student who came to the aid of a man with Parkinsons disease on a train in Cardiff has been tracked down after a social media appeal. David Murray 'could barely move' after his medication ... […]
Chipping in for Parkinsons
on April 11, 2019 at 8:29 am
The 4th Annual Chipping in for Parkinsons event is coming up in June and founders Jim and Rebecca joined us with how we can get involved. […]
'I got Parkinsons aged 40 - but a pioneering operation has given me back my family life'
on April 11, 2019 at 4:04 am
Around 600 patients undergo DBS or deep brain stimulation each year. Though the procedure – which involves planting electrodes into the brain to control movement – does not work for everyone, for ... […]
via Bing News