A team of researchers from Italy, Israel and the United Kingdom has succeeded in generating mature, functional skeletal muscles in mice using a new approach for tissue engineering.
The scientists grew a leg muscle starting from engineered cells cultured in a dish to produce a graft. The subsequent graft was implanted close to a normal, contracting skeletal muscle where the new muscle was nurtured and grown. In time, the method could allow for patient-specific treatments for a large number of muscle disorders. The results are published in EMBO Molecular Medicine.
The scientists used muscle precursor cells – mesoangioblasts – grown in the presence of a hydrogel (support matrix) in a tissue culture dish. The cells were also genetically modified to produce a growth factor that stimulates blood vessel and nerve growth from the host. Cells engineered in this way express a protein growth factor that attracts other essential cells that give rise to the blood vessels and nerves of the host, contributing to the survival and maturation of newly formed muscle fibres. After the graft was implanted onto the surface of the skeletal muscle underneath the skin of the mouse, mature muscle fibres formed a complete and functional muscle within several weeks. Replacing a damaged muscle with the graft also resulted in a functional artificial muscle very similar to a normal Tibialis anterior.
Tissue engineering of skeletal muscle is a significant challenge but has considerable potential for the treatment of the various types of irreversible damage to muscle that occur in diseases like Duchenne muscular dystrophy. So far, attempts to re-create a functional muscle either outside or directly inside the body have been unsuccessful. In vitro-generated artificial muscles normally do not survive the transfer in vivo because the host does not create the necessary nerves and blood vessels that would support the muscle’s considerable requirements for oxygen.
“The morphology and the structural organisation of the artificial organ are extremely similar to if not indistinguishable from a natural skeletal muscle,” says Cesare Gargioli of the University of Rome, one of the lead authors of the study.
The Latest on: Tissue engineering
Tissue Engineering Market in the U.S. - Genetic Engineering & Biotechnology News
February 7, 2019 - Tissue Engineering Market in the U.S. Genetic Engineering & Biotechnology NewsAn analysis of the $9 billion/year market for tissue engineering products finds that 21 of 49 companies in the segment are responsible for the revenue.
tissue engineering - The Smart Set
February 18, 2019 - tissue engineering The Smart SetArtist and researcher Oron Catts discusses the challenges of growing meat and leather in the laboratory. By Arvind Dilawar. Email Twitter Facebook Digg ...
What Are The Tissue Engineering Market Trends, Opportunities And Growth Drivers? - Oak Tribune
February 19, 2019 - What Are The Tissue Engineering Market Trends, Opportunities And Growth Drivers? Oak TribuneTissue Engineering Market report to show positive growth owing to rising demand from various sectors. Research Expert in Tissue Engineering has announced ...
BioEngineering, BioDetection & BioSensors Conference: Devices, Biofabrication Technologies, Tissue Engineering & Synthetic Biology - San Diego, CA, United States - April 1st-2nd, 2019 - PRNewswire
February 12, 2019 - BioEngineering, BioDetection & BioSensors Conference: Devices, Biofabrication Technologies, Tissue Engineering & Synthetic Biology - San Diego, CA, United States - April 1st-2nd, 2019 PRNewswireDUBLIN, Feb. 12, 2019 /PRNewswire/ -- The "BioEngineering, BioDetection & BioSensors" conference has been added to ResearchAndMarkets.com's offering.
Global Market Report From IDTechEx Research on Tissue Engineering 2018-2028: Technologies, Markets, Forecasts - PRNewswire
January 31, 2019 - Global Market Report From IDTechEx Research on Tissue Engineering 2018-2028: Technologies, Markets, Forecasts PRNewswireBOSTON, Jan. 31, 2019 /PRNewswire/ -- Tissue engineering, referring to the technologies that use physical, chemical, biological and engineering processes to ...
Global Regenerative Medicine Market Analysis & Forecast to 2023: Stem Cells, Tissue Engineering, BioBanking & CAR-T Industries - PRNewswire
February 14, 2019 - Global Regenerative Medicine Market Analysis & Forecast to 2023: Stem Cells, Tissue Engineering, BioBanking & CAR-T Industries PRNewswireNEW YORK, Feb. 14, 2019 /PRNewswire/ -- This report provides a comprehensive overview of the size of the regenerative medicine market, segmentation of the ...
Maintaining the Utility of Stem Cells in Tissue Engineering - PRNewswire
February 7, 2019 - Maintaining the Utility of Stem Cells in Tissue Engineering PRNewswireWASHINGTON, Feb. 7, 2019 /PRNewswire/ -- An article published in Experimental Biology and Medicine (Volume 244, Issue 1, January, 2019) ...
Printer suited to cell culture and tissue engineering launched - Medical Plastics News
January 23, 2019 - Printer suited to cell culture and tissue engineering launched Medical Plastics NewsMicroprinting machines manufacturer Microlight3D has launched a new printer for producing micro-parts, which can be suited to cell culture and tissue ...
Artificial Valve Market 2019: by Top Key Players Colibri Heart Valve, Cytograft Tissue Engineering, Direct Flow Medical - Spot Herld
February 19, 2019 - Artificial Valve Market 2019: by Top Key Players Colibri Heart Valve, Cytograft Tissue Engineering, Direct Flow Medical Spot Herld[Los Angeles, United State- Feb 19, 2019]: The market research report is a compilation of comprehensive intelligence studies that explore almost every aspect of ...
Global Regenerative Medicine Market Assessment and Forecast 2028 - Financial Strategy
February 19, 2019 - Global Regenerative Medicine Market Assessment and Forecast 2028 Financial StrategyGlobal Regenerative Medicine Market by Applications, Types, New Technology, Growth Opportunity with Overview by Rising Demands and Forecast 2019 To ...