Led by Dr Jiri Cervenka and PhD candidate Nikolai Dontschuk from the University of Melbourne, the study also included scientists from the Australian Synchrotron and La Trobe University and is published in Nature Communications.
The Australian researchers have shown that graphene- a one-atom thick sheet of hexagonally arranged carbon, shaped like chicken wire – can detect the four nucleobases that make up DNA (cytosine, guanine, adenine and thymine).
A unique combination of the four nucleobases makes up the individual DNA sequence of a gene. Currently, DNA sequencing is a fundamental tool for medical diagnostics, forensic testing and medical and biological research.
The use of graphene to electrically sequence DNA promises to improve the speed, throughput, reliability and accuracy whilst reducing the price compared to current techniques said Nikolai Dontschuk from the University of Melbourne.
“We found that each nucleobase influenced the electronic structure of graphene in a measurably different way,” said Mr Dontschuk.
“When used in conjunction with a nanopore (a tiny hole), a single DNA molecule would pass through the graphene-based electrical sensor – like a single string of beads passing through one section of tiny chicken wire- enabling real-time, high-throughput sequencing of a single DNA molecule.”
The Latest on: Real time DNA sequencing
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The Latest on: Real time DNA sequencing
A 'biomultimeter' to measure RNA and protein production in real-time
on May 21, 2019 at 4:27 am
With such methods, a gene that carries instructions to produce fluorescent pigments can be fused to a gene in a DNA sequence that will ... They also take time to emit their signal; thus, GFP ... […]
A “biomultimeter” lets scientists measure RNA and protein production in real-time
on May 20, 2019 at 9:44 am
The system, called PERSIA, uses fluorescent labeling to illuminate different parts of a genetic circuit and allows researchers to measure biological functions – including transcription, translation, ... […]
DNA Sequencing Market Research Report By 2023 | Global Industry Size, Share, Top Company Analysis, Technology Developments, Key Regions
on May 15, 2019 at 4:35 pm
By mode of technology, the global DNA sequencing market has been segmented into pyrosequencing, semiconductor sequencing, single-molecule real-time sequencing (SMRT), sequencing by synthesis, ... […]
The Global DNA Sequencing Market is Expected to Grow at a CAGR of 18.19% by 2027
on May 8, 2019 at 3:45 am
“Global DNA Sequencing market was valued around $9,292 thousand ... by Pyrosequencing, Single-molecule Real-time Sequencing & Other), by Application (Diagnostics, Drug Discovery, Biomarker Discovery, ... […]
The sequence of events during folding of a DNA origami
on May 3, 2019 at 11:04 am
We found a complex sequence of folding events that cannot be explained with simplistic local design analysis. Our real-time data, although derived from one specific DNA origami object, through its ... […]
Oxford Nanopore Launches MinIT, Enabling Real Time, Portable DNA Sequencing
on May 1, 2019 at 5:00 pm
October 12, 2018 | Oxford Nanopore has announced they are shipping their new MinIT, a rapid analysis and device control accessory for nanopore DNA sequencing, to genomics researchers. MinIT, equipped ... […]
Pacific Biosciences Launches New Sequel II System, Featuring ~8 Times the DNA Sequencing Data Output Nasdaq:PACB
on April 24, 2019 at 5:02 am
About Pacific Biosciences Pacific Biosciences of California, Inc. (NASDAQ: PACB ) offers sequencing systems to help scientists resolve genetically complex problems. Based on its novel Single Molecule, ... […]
Mobile DNA Sequencing in the Ebola Epidemic
on April 17, 2019 at 5:00 pm
February 3, 2016 | Just over a year ago, Bio-IT World spoke to microbiologist Nick Loman about the recently released MinION DNA sequencer. The three-inch-long device, made by Oxford Nanopore ... […]
Application of cell-free DNA sequencing in characterization of bloodborne microbes and the study of microbe-disease interactions
on March 14, 2019 at 5:00 pm
Recent reports indicated that cell-free DNA (cfDNA) sequencing using advanced sequencing ... Single-molecule sequencing (SMS) using either SMRT (single-molecule real-time) sequencing or Nanopore ... […]
Oxford Nanopore Launches Flongle for Rapid, Smaller DNA/RNA Sequencing Tests in Any Environment
on March 12, 2019 at 10:31 am
At UC Santa Cruz, we now routinely sequence native RNA and genomic DNA libraries on a Flongle Flow Cell before ... https://nanoporetech.com/products/minion-mk1c, which combines the real-time, portable ... […]
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