Protection from chemotherapy immunosuppression indicates effect could be conserved in humans
In the first evidence of a natural intervention triggering stem cell-based regeneration of an organ or system, a study in the June 5 issue of the Cell Stem Cell shows that cycles of prolonged fasting not only protect against immune system damage — a major side effect of chemotherapy — but also induce immune system regeneration, shifting stem cells from a dormant state to a state of self-renewal.
In both mice and a Phase 1 human clinical trial involving patients receiving chemotherapy, long periods of not eating significantly lowered white blood cell counts. In mice, fasting cycles then “flipped a regenerative switch,” changing the signaling pathways for hematopoietic stem cells, which are responsible for the generation of blood and immune systems, the research showed.
The study has major implications for healthier aging, in which immune system decline contributes to increased susceptibility to disease as people age. By outlining how prolonged fasting cycles — periods of no food for two to four days at a time over the course of six months — kill older and damaged immune cells and generate new ones, the research also has implications for chemotherapy tolerance and for those with a wide range of immune system deficiencies, including autoimmunity disorders.
“We could not predict that prolonged fasting would have such a remarkable effect in promoting stem cell-based regeneration of the hematopoietic system,” said corresponding author Valter Longo, Edna M. Jones Professor of Gerontology and the Biological Sciences at the USC Davis School of Gerontology and director of the USC Longevity Institute. Longo has a joint appointment at the USC Dornsife College of Letters, Arts and Sciences.
“When you starve, the system tries to save energy, and one of the things it can do to save energy is to recycle a lot of the immune cells that are not needed, especially those that may be damaged,” Longo said. “What we started noticing in both our human work and animal work is that the white blood cell count goes down with prolonged fasting. Then when you re-feed, the blood cells come back. So we started thinking, well, where does it come from?
The Latest on: Stem cell regeneration
via Google News
The Latest on: Stem cell regeneration
- Stem cell treatments: Miracle cures or dangerous experiments?on September 8, 2019 at 5:26 am
These cells have regenerative properties, but may or may not include actual stem cells. Calling something a stem cell treatment is great marketing, but without regulation patients don’t know ...
- Researchers discover potential of antihistamines that cause death of leukemic stem cellson September 6, 2019 at 8:35 pm
Nevertheless, leukemic stem cells are responsible for the initiation, maintenance, and regeneration of the disease. To die them, they can be killed, death induced or differentiation induced into ...
- The American Academy of Stem Cell Physicians Sets the Safety Industry Standard in Regenerative Medicineon September 6, 2019 at 5:11 pm
The AASCP has set up safety guidelines for Physicians who use regenerative therapies in their practice. MIAMI, Sept. 6, 2019 /PRNewswire/ -- The American Academy of Stem Cell Physicians, strives ...
- Pitt’s McGowan Institute aims to study stem cells, 3D printers in spaceon September 6, 2019 at 6:40 am
Pitt’s McGowan Institute for Regenerative Medicine will collaborate with the ISSNL Industrial Biomedicine Program on research that will look at the unique behavior of stem cells in microgravity ...
- R3 Stem Cell On The Future Of Stem Cell Therapy Treatmentson September 5, 2019 at 11:27 pm
Stem cell therapy is regenerating and restoring the health of patients afflicted with various chronic ailments worldwide. Patients seeking pain relief along with an increased quality of life have been ...
- Heart regeneration: Scientists uncloak one of nature's deepest secretson September 5, 2019 at 6:32 am
Now, in a new development, the scientists have pinpointed genes, their protein products and a cascade of cells, including macrophages from the immune system, involved in the regeneration process.
- Don’t Believe Everything You Hear about Stem Cellson September 4, 2019 at 1:26 pm
Since late 2017, the Food and Drug Administration has stepped up its regulatory enforcement of stem cell therapies and provided a framework for regenerative medicine products that provides ...
- Global Stem Cell Therapy Market to Reach $11 Billion by 2029: BIS Researchon September 4, 2019 at 4:30 am
Regenerative medicine is an interdisciplinary field that involved the replacement or repair of the damaged tissue or organs, thereby completely curing the disease. Stem cells represent a ...
- R3 Stem Cell Provider Training Now Enrolling for October 18-19, 2019 Courseon September 4, 2019 at 3:00 am
4, 2019 /PRNewswire-PRWeb/ -- R3 Stem Cell is now enrolling for the next provider training course scheduled for October 18-19th, 2019. The nation's leading hands-on regenerative training course ...
- FDAnews Announces -- Regenerative Medicine and...on September 2, 2019 at 9:00 pm
Confused about the FDA's regenerative medicine and stem cell therapies regulations? This webinar will explain FDA's regulations and enforcement, and how stem cell stakeholders (pharma/biotech ...
via Bing News