Given a choice, most patients would prefer to take a drug orally instead of getting an injection. Unfortunately, many drugs, especially those made from large proteins, cannot be given as a pill because they get broken down in the stomach before they can be absorbed.
To help overcome that obstacle, researchers at MIT and Massachusetts General Hospital (MGH) have devised a novel drug capsule coated with tiny needles that can inject drugs directly into the lining of the stomach after the capsule is swallowed. In animal studies, the team found that the capsule delivered insulin more efficiently than injection under the skin, and there were no harmful side effects as the capsule passed through the digestive system.
“This could be a way that the patient can circumvent the need to have an infusion or subcutaneous administration of a drug,” says Giovanni Traverso, a research fellow at MIT’s Koch Institute for Integrative Cancer Research, a gastroenterologist at MGH, and one of the lead authors of the paper, which appears in the Journal of Pharmaceutical Sciences.
Although the researchers tested their capsule with insulin, they anticipate that it would be most useful for delivering biopharmaceuticals such as antibodies, which are used to treat cancer and autoimmune disorders like arthritis and Crohn’s disease. This class of drugs, known as “biologics,” also includes vaccines, recombinant DNA, and RNA.
“The large size of these biologic drugs makes them nonabsorbable. And before they even would be absorbed, they’re degraded in your GI tract by acids and enzymes that just eat up the molecules and make them inactive,” says Carl Schoellhammer, a graduate student in chemical engineering and a lead author of the paper.
Safe and effective delivery
Scientists have tried designing microparticles and nanoparticles that can deliver biologics, but such particles are expensive to produce and require a new version to be engineered for each drug.
The Latest on: Drug-delivery capsule
via Google News
The Latest on: Drug-delivery capsule
- Oramed Completes Patient Recruitment of Phase IIb HbA1c Trial for Oral Insulin Capsule ORMD-0801 on May 21, 2019 at 7:52 am
ORMD-0801 reaches significant milestone on path to potentially be the first commercial oral insulin capsule for the treatment ... on the development of oral drug delivery systems, announced ... […]
- Smartpills Market Plot Concludes Heavy Growth in the Industry on May 13, 2019 at 4:18 am
Segmentation on the basis of technology type: Capsule Endoscopy, Drug Delivery, Patient Monitoring It also includes a review of various supporter along with manufacture study, market size, share, ... […]
- Global Smart Pills Market is Expected to Reach $650 Million by 2025 on May 13, 2019 at 2:03 am
Based on application, the market is divided into capsule endoscopy, drug delivery, and patient monitoring. Based on target area, the market is classified into esophagus, small intestine, large ... […]
- DNA folds into a smart nanocapsule for drug delivery on April 29, 2019 at 5:02 am
Further, the capsules remained functional at physiological ... these findings help pave the way for developing smart and fully programmable drug-delivery vehicles for nanomedicine. ... […]
- Nanostructures made of DNA pave way towards functional drug-delivery vehicles on April 28, 2019 at 9:54 pm
Further, the capsules remained functional at physiological magnesium ... Together, these findings help pave the way for developing smart and fully programmable drug-delivery vehicles for nanomedicine. ... […]
- Empty Capsules Market is expected surpass USD 3,707.5 Million by 2025 on April 25, 2019 at 4:27 pm
The popularity of capsule drug delivery form has increased in the recent years because capsules act as relatively stable shells protecting the active pharmaceutical ingredients (APIs) and enable ... […]
- Nanomedical capsule in cancer treatment on March 8, 2019 at 4:00 pm
Such nanocapsule can be widely used in medical applications. Programmable drug delivery nanomechanical capsule is the next step in the target drug delivery technology. Size of nanocapsule is near 1 ... […]
- Smart Capsule Aims to Ease Medicating and Monitoring Diseases on December 27, 2018 at 10:26 pm
It can also communicate wirelessly via an app. (Image courtesy of MIT.) The team has been working for a few years on ingestible sensors and drug delivery capsules for long-term delivery—especially for ... […]
- 3D Printed Capsules Deliver Drugs and Communicate via Bluetooth on December 14, 2018 at 12:24 am
For several years, the research team has been working on the development of ingestible sensors and drug delivery capsules, which could replace long-term drugs that currently have to be injected. They ... […]
- Simpler drug delivery through capsule-based inhalation on December 10, 2018 at 6:08 am
Delivery by inhalation could be an easier way to deliver therapies in areas such as oncology, suggested ACG’s development manager. Using the lungs as the delivery point for drugs is not a new ... […]
via Bing News