When a foreign material like a medical device or surgical implant is put inside the human body, the body always responds. According to Northwestern’s Guillermo Ameer, most of the time, that response can be negative and affect the device’s function.
“You will always get an inflammatory response to some degree,” said Ameer, professor of biomedical engineering in McCormick School of Engineering and Applied Science and professor of surgery in the Feinberg School of Medicine. “A problem with commonly used plastic materials, in particular, is that in addition to that inflammatory response, oxidation occurs.”
We all need oxygen to survive, but a high concentration of oxygen in the body can cause oxidative reactions to fall out of balance, which modifies natural proteins, cells, and lipids and causes them to function abnormally. This oxidative stress is toxic and can contribute to chronic disease, chronic inflammation, and other complications that may cause the failure of implants.
For the first time ever, Ameer and his team have created a biodegradable biomaterial that is inherently antioxidant. The material can be used to create elastomers, liquids that turn into gels, or solids for building devices that are more compatible with cells and tissues. The research is described in the June 26 issue of Biomaterials.
“Plastics can self-oxidize, creating radicals as part of their degradation process,” Ameer said. “By implanting devices made from plastics, the oxidation process can injure nearby cells and create a cascade that leads to chronic inflammation. Our materials could significantly reduce the inflammatory response that we typically see.”
The Latest on: Antioxidant biomaterial
via Google News
The Latest on: Antioxidant biomaterial
- The Gamma Radiation Tolerance of Polypropylene: Measurement and Enhancementon October 5, 2020 at 5:00 pm
Whereas the embrittlement of the plastic after irradiation is an inherent property of the polymer, the discoloration is caused by reaction products of the phenolic antioxidants normally included in ...
- IMPROVING THE GAMMA RESISTANCE OF FLEXIBLE PVCon October 5, 2020 at 5:00 pm
To minimize this effect, compound formulation is critical: the choice of resin, stabilizer, lubricant, and antioxidant can all affect color stability after gamma exposure. This article describes an ...
- New antioxidant biomaterial prevents medical implant failure, promotes healingon September 22, 2020 at 5:00 pm
Ameer and his team have created what they describe as the world's first biodegradable biomaterial that is inherently antioxidant. The material can be used to create elastomers, liquids that turn into ...
- Gadofullerene inhibits the degradation of apolipoprotein B100 and boosts triglyceride transport for reversing hepatic steatosison September 11, 2020 at 2:18 pm
Of note, we demonstrate that GF-Ala markedly inhibits the posttranslational degradation of apolipoprotein B100 (ApoB100) and boosts hepatocellular TG transport based on their superior antioxidant ...
- Frozen Fruit Market Expected To Grow Faster According New Research Report 2020on August 24, 2020 at 10:21 pm
The full version of the report will include the impact of COVID-19 and the expected changes in the future prospects of the sector, taking into account political, economic, social and technological ...
- Life Sciences A - Zon August 13, 2020 at 12:25 pm
In this interview, Dr. Hadi Yassine and Dr. Hassan Zaraket speak about their research into whether COVID-19 will become a seasonal virus.
- A Healthy Market for Innovationon January 2, 2020 at 8:57 am
Indeed, spider silk has become a bit of a darling in the medical industry, with its high tensile strength, recognized as some of the strongest natural biomaterial ... C is an antioxidant that ...
- Animal Feed Additive Market: Global Industry Analysis and Opportunity Assessment 2019-2025on September 27, 2019 at 12:06 am
Some of the feed additives which are commonly used for livestock growth are growth promotion additives, antimicrobials, feed enzymes, antioxidants, acidifiers, probiotics and prebiotics.
- Recent Publicationson October 19, 2017 at 11:41 am
2013 Jun. Zheng H Mortensen LJ DeLouise LA Thiol antioxidant-functionalized CdSe/ZnS quantum ... on the E-selectin mediated adhesive properties of breast cancer cell lines.; Biomaterials; Vol 33(35).
- Extracting Synergistic Mixtures From Plants For The Booming Skin Care Marketon June 4, 2017 at 10:08 pm
Developed by Michael Koganov, vice president of BioMaterials ... of the lotus have suggested it is rich in chemicals (including antioxidants) that could have such effects. Harmoniance is made ...
via Bing News