Biohybrid systems allow for new applications in food technology, molecular biology, medical diagnostics, and pharmaceutical industry
Cells, biological circuits, and individual biomolecules organize themselves and interact with the environment. Use of these capabilities in flexible and economically efficient biotechnological production systems is in the focus of the “Molecular Interaction Engineering” (MIE) project. It is the objective to develop printed biological circuits and catalysts for biologico-technical hybrid systems. MIE will be funded with about EUR 3.5 million by the BMBF.
The capabilities of biological systems are based on specific interactions of molecular components. Due to their molecular fitting accuracy, for instance, enzymes allow for certain chemical reactions only. Some proteins bind via specific molecular interfaces to the DNA or other proteins and control processes in complex organisms. Sensors respond to defined molecular signals from the environment. The MIE project focuses on interactions of molecules, technical interfaces, and surrounding solvents.
“Transfer of complex biological mechanisms to printable systems may result in innovative biotechnologies that might be the basis of a number of industrial applications,” Professor Jürgen Hubbuch, project coordinator at KIT, explains. However, conventional, continuous evolution of biological molecules reaches its limits. The key to innovative developments is the specific, adjusted construction of the interaction of complex biomolecules and fusion of these units with technical interfaces. This requires close cooperation of biology, engineering, chemistry, and physics.
The “Molecular Interaction Engineering” (MIE) project combines methods of biotechnology, structural biology, materials sciences, process engineering, and computer simulation. Work is aimed at developing innovative, flexible, and economically efficient biotechnological production systems for molecules. These might then be used in biohybrid systems integrating biological and electronic components. Biohybrid systems allow for new applications in food technology, molecular biology, medical diagnostics, and pharmaceutical industry.
The Latest on: Printable Biotechnology
- Researchers 3D-print heart from human patient’s cells on April 17, 2019 at 1:33 pm
“But larger human hearts require the same technology.” Previously, scientists had been able to print only simple tissues without blood vessels. Cardiovascular disease is the leading cause of ... […]
- TAU scientists print first ever 3D heart using patient’s own cells on April 17, 2019 at 4:51 am
Tal Dvir of TAU's School of Molecular Cell Biology and Biotechnology, Department of Materials Science ... "People have managed to 3D-print the structure of a heart in the past, but not with cells or ... […]
- Researchers 3D Print Heart Using Human Cells on April 17, 2019 at 12:01 am
ventricles and chambers," Professor Tal Dvir of Tel Aviv University's School of Molecular Cell Biology and Biotechnology said. He is also the senior author of the research published Monday in Advanced ... […]
- Scientists manage to 3D print an actual heart using human cells on April 16, 2019 at 12:11 pm
While people have previously been able to 3D print a heart structure ... in the future,” Professor Tal Dvir of TAU’s School of Molecular Cell Biology and Biotechnology said in a statement. The heart ... […]
- Israelis Print World’s First 3D Heart with Blood Vessels on April 16, 2019 at 9:27 am
who led the project at Tel Aviv University’s School of Molecular Cell Biology and Biotechnology. Previously, scientists in the emerging field of regenerative medicine have been able to print cartilage ... […]
via Google News and Bing News